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Biomedical subjects

H Schill

Publications and source records attributed to H Schill.

At least 55 records · Page 3Linked to original sources

[Carriage of HBs antigen in New Caledonia. Study according to ethnic group].

Owing to 2,772 New Caledonian blood donors and pregnant women, a study was made of the salient features of the H. B. s. antigen carrier state; percentages of carriers showed no difference according to the age and a slight difference between sexes. These percentages proved to be quite different according to ethnic groups. Smaller rates of carriers were found among Europeans (1.1%) than among Melanesians (7.6%) as well as Polynesians (7.7%). There is a relation between H. B. s. carrier state and positive treponema serology, the latter occurring more frequently among melanesian and polynesian groups.

Adolescent↗

[The last offensive of leprosy in the South Pacific Ocean: the epidemic on Rapa (1922-1950)].

The observations of leprosy outbreaks are exceptional and always situated in isolated countries. The authors give the example of Rapa, small island in French Polynesia, where an epidemic has occurred from 1922 to 1950. They made the study of the different parameters by retrospective methods and fieldwork. After an 11% incidence rate and an 68% prevalence rate, the outbreak seems today off. Now leprosy is endemosporadic.

Female↗

[Mediator concepts and modulation of renal compensatory adaptation].

In the renal compensatory adaptation after the definition and the description of the fundamental phenomena of the functional compensation as well as of the structural adaptation is reported on mediator concepts and on modulations of the renal adaptation processes. Issuing from the central position of the sodium balance a mediator concept on natriuretic hormones (Auriculin and Endoxin) is developed which is supplemented by the renotropin mediator concept. The authors deal with the modulation of the renal compensatory adaptation (e.g. influences of age diet and so on). The pharmacotherapeutic modulation of the renal compensatory adaptation is discussed with regard to the stimulation of the tubulosecretory transport of foreign substances with para-amino hippuric acid as principal substance (including own investigations with cyclopenthiazide [Benesal].

Adaptation, Physiological↗

[Incidence of glomerular diseases in kidney biopsy materials using WHO classification].

A total of 1,308 renal biopsies performed during the years 1978 to 1983 in Moscow (M, 852 cases) and Rostock (R, 456 cases) showed that 685 (80.4%) and 346 (75.9%), in the two cities respectively, had glomerular disorders when classified according to WHO nosology (Churg and Sobin 1982). Among the 1,031 glomerulopathies from the two cities there were 121 with minor glomerular abnormalities (M: 49 = 7.1%; R: 72 = 20.8%), 145 with focal segmental glomerulopathies (M: 76 = 11.1%; R: 69 = 20.0%), and 765 with diffuse glomerulopathies (M: 560 = 81.6%; R: 205 = 59.3%). The 765 diffuse glomerulopathies from the two series were distributed according to the WHO classification into 77 membranous (M: 63 = 9.25%; R: 14 = 4.1%), 519 mesangioproliferative (M: 380 = 55.5%; R: 139 = 40.2%), 11 endocapillary proliferative (M: 5, R: 6), 99 mesangiocapillary (M: 65 = 9.5%; R: 34 = 10.4%), 2 dense deposit (in R), 4 extracapillary (M: 1, R: 3) and 53 sclerosing glomerulonephritides (M: 46 = 6.7%; R: 7 = 2.0%). Utilization of the WHO classification of glomerular diseases proved to be a useful compromise, allowing two different schools of nephropathology to agree on classification of renal biopsy material. The group of minimal change abnormalities and the focal segmental lesions should be subclassified further according to the clinical and morphologic findings.

Anti-Glomerular Basement Membrane Disease↗

Effect of autovaccination on the course of urinary tract infection in animal experiment.

Autovaccination of rats with chronic pyelonephritis carried out approximately two months after the onset of infection does not result in an improved histological picture in the infected but can prevent destructive processes in the controlateral kidney. Cyclophosphamide administered in three doses of 30 mg/kg simultaneously with autovaccination slightly modulates the immune response to the infectious strain. The temporal relationship between immunization and cyclophosphamide administration determines the mode of action of cyclophosphamide. In the present experiment, the concept of Miller has not proved to be applicable. Cyclophosphamide administration causes a distinct increase in inflammatory processes in the kidney. Should an enhancement phenomenon be involved in the bacterial infection of the kidney, of which we have found no proof, cyclophosphamide therapy as it was used in the present study would not result in its removal and thus in improved elimination of the infectious organism. Additional experiments are required to determine whether animals subjected to autovaccination are protected against a new episode of urinary tract infection.

Animals↗

[Adaptive and compensatory reactions in the liver].

The bioptic specimens of liver taken from 687 patients with various acute and chronic liver diseases were studied by means of the modern morphological methods. It was found, that structural changes, that reflect the adaptive-compensatory reactions are seen in hepatocytes, in epithelial cells of the interlobular bile ducts and in the connective tissue.

Bile Ducts, Intrahepatic↗

[Preliminary results of the vaccine treatment of chronic pyelonephritis in animal experiments].

The immunization of rats with a formaldehyde-inactivated vaccine of the homologous infection strain does not lead to an improved tendency for an existing infection of the urinary tract to heal in the primarily infected kidney, but it can prevent it spreading to the other one. The dose is probably significant. In previously published investigations this effect did not occur after six vaccinations (11). In existing infection cyclophosphamide treatment does not prevent any possible enhancement and thus does not improve the elimination of germs.

Animals↗

[Enzymatic and morphologic studies on long-term perfused dog kidneys].

21 canine and 12 human kidneys were submitted to long-term perfusion for 24 hours. During that time LDH-activity, histologic, enzyme-histochemic, and ultrastructural examinations were carried out. The findings proved that kidneys with lesser damage from ischemia showed lower activities during the first 4 to 6 hours than kidneys which were more injured before. The latter showed the same ultrastructural alterations as kidneys after perfusion for 24 hours, which suggests an irreversible partial damage of the organ.

Albumins↗

[Electron microscopic studies on long-term perfused dog kidneys].

In the applied preservation technique of kidneys used the fine-structural changes on main epithelial cells and glomeruli are relatively insignificant and appear reversible or reparable after a storage preservation up to 4 hours and permanent perfusion of 24 hours. After a storage preservation of 10 hours and an additional permanent perfusion of 24 hours and after a renal permanent perfusion during 48 hours compared to it most frequently irreversible damages in form of dystrophies and necroses on tubuli and glomeruli are the result, so that the conservative condition of the organ can no more be regarded as optimal. Such kidneys are certainly only conditionedly suited for a transplantation.

Animals↗

[Lyophilized split pigskin for biological wound dressings (author's transl)].

Experimental and clinical investigations of an unviable split pigskin preserve, produced by a fairly simple industrial process, outline the following results: The skin preserve protects a wound surface against infection and prevents loss of fluid. The reaction of the wound surface is very restricted even after repeated application, whilst the viable pigskin releases a more intense host reaction.

Animals↗