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Biomedical subjects

H Schieffer

Publications and source records attributed to H Schieffer.

At least 127 records · Page 7Linked to original sources
PubMed1976

[Influence of a pressure agent on blood concentrations of glucose, lactate, pyruvate and free fatty acids (author's transl)].

In 34 unselected patients blood concentrations of glucose, lactate, pyruvate and free fatty acids (FFA) were determined after i.v. injection of a pressure agent containing theophylline esterified with norephedrine and theophylline esterified with norepinephrine (Akrinor) with and without beta-adrenergic blockade. After Akrinor a significant increase of FFA concentration of 32% is observed, which can be abolished by beta-receptor blocking agents. Our findings indicate that the Akrinor-induced lipolysis is mainly due to a direct sympathomimetic effect on the beta-receptors of adipose tissue. there are only slight effects on carbohydrate metabolism (decrease of pyruvate concentration, increase of lactate/pyruvate ratio) which are not influenced by beta-receptor blockade. According to our results there are important metabolic differences between Akrinor and the classical catecholamines.

Blood Glucose↗
PubMed1975

[Effect of Akrinor on cardiovascular-dynamics before and after blockade of adrenergic beta-receptors by propranolol].

On healthy volunteers it is tested whether the cardiovascular and central stimulating effect of Akrinor and the depressive effect of propranolol influence each other mutually. Akrinor causes an increase in arterial pressure, in cardiac stroke volume and cardiac output in connection with a decrease in peripheral vascular resistance and in heart rate. These changes are abolished by propranolol whereas the central stimulating effect on the respiratory minute volume and the oxygen consumption is not influenced. After blocking of the beta-receptors, Akrinor exerts a diminished influence on the cardiovascular dynamics, a stimulation of the alpha-receptors cannot be evidenced. The findings are being discussed and compared with the effect of noradrenaline and adrenaline.

Drug Combinations↗
PubMed1975

[Determination of cardiac output using impedance-cardiography in comparison with conventional methods during rest and under pharmacological stress].

A recording of the changes in the transthoracic resistance as a function of the cardiac cycle enables--in connection with the ejection time--a non-invasive determination of the cardiac output (impedance cardiography). On volunteers without heart diseases the cardiac output according to the Fick principle, the impedance-cardiographic and sphygmographic method at rest and under pharmacological influence is synchronously measured and statistically compared with the found cardiac output according to Fick. Especially under pharmacological influence the impedance-cardiographically determined values do not show a sufficient correlation. The range of error, is causes as well as the limited possibility of application of the method are being discussed.

Cardiac Output↗