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Biomedical subjects

H Scheld

Publications and source records attributed to H Scheld.

29 records · Page 2Linked to original sources

[Antidiuretic hormone in peridural anesthesia with 0.5% bupivacaine. The effect of severe blood loss on ADH release].

14 patients scheduled for peripheral vascular surgery received epidural anaesthesia with bupivacaine 0.5%. Blood samples were obtained preoperatively (twice), intraoperatively (9 times) and postoperatively (3 times) for analysing the following parameters: 1. antidiuretic hormone (ADH, arginine-vasopressin) 2. serum electrolytes (potassium, sodium) 3. plasma osmolality In three patients unexpected sudden blood loss occurred, accompanied by typical haemodynamic changes. Pre- and intraoperative ADH-levels were normal with a slight increase at the end of the operative procedure. Electrolytes and osmolality in serum/plasma stayed within the normal range during the whole investigation period. In three patients suffering from shock due to unexpected blood loss ADH-levels rose excessively. The data demonstrate the well-known stress-attenuation under EDA as well as an increase of ADH-secretion in haemodynamic alteration.

Anesthesia, Epidural↗

[Bicycle ergometric examinations and pulmonary function analyses after patch aortoplasty of coarctation of the aorta in children (author's transl)].

The blood pressure of patients who underwent surgical correction of coarctation of the aorta are usually controlled at rest in the upper and lower extremities. The assessment of the success of the operation is then based on these blood-pressure readings. It is, however, more important to control the blood pressure during standardized exercise so that assessment of the capacity for work in daily life could be made. This is best realized with the bicycle ergometric examination with simultaneous blood-pressure readings 40 patients who had undergone surgical correction of the coarctation of the aorta, using the Vossschulte indirect patch aortoplasty method, were examined. The examination results were compared with those of 35 healthy children. The bicycle-ergometric exercise was carried out in stepwise increasing loads of up to 2 Watt/kg body weight. The blood-pressure, were compared based on the age of the patient at the time of the operation, in relation to the time between the operation and the ergometric examination and the age of the patient at the time of the operation. The W170 (Physical working capacity at a heart rate of 170) and the maximum oxygen intake of the subjects were also used as parameters for comparison. It could be seen that the initial blood pressure at rest was, on the average, relatively higher than those of the control subjects. This tendency was also observed during the bicycle-ergometric examination. In some subjects, the blood pressure rose to dangerously high values particularly at 2 Watt/kg body weight. The blood pressures of the patients remained on the average higher than those of the control subjects during the resting phase after the exercise (control after 1' and 5') and normalized relatively slowly. 45% of the patients showed pathological blood-pressure values. The W170 of the patients, a parameter for precise assessment of the cardiorespiratory fitness, was measured. The findings in the patients showed only very slight difference compared to those of normal subjects in all the assessment parameters. This applies also to the maximum oxygen supply, particularly when one considers the standard deviation. It is advisable to consider limitation of activities, for example sport, in the special cases where there are dangerously high blood-pressure rises during exercise even though no subjective complaints are made by the patients and the blood pressures at rest are normal. It is, on the whole, interesting to note that the operated patients compare very favourably with the control subjects in the W170 and the maximum oxygen-intake values.

Adolescent↗

[Cardiac and vascular effects of midazolam during induction of anesthesia prior to and during extracorporeal circulation in coronary-surgical patients (author's transl)].

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is a new benzodiazepine which, when compared with its predecessors diazepam (Valium) and flunitrazepam (Rohypnol), has several outstanding advantages: We conducted hemodynamic investigations with 0.15 mg/kg b.w. midazolam in a total of 28 coronary patients divided into 3 groups. The new water-soluble benzodiazepine is at the dose given useful in the induction of and as an adjuvant to anesthesia because of its hemodynamic effect.

Anesthetics↗

[Injury to the mediastinal organs in chest trauma (author's transl)].

10% of chest traumata are accompanied by injuries to the mediastinal organs. Since rupture of a bronchus may be masked by additional intrathoracic injuries any suspicion of such lesion must be verified by bronchoscopy. Symptoms of a shock condition after traumatization of the precordial region point to damage to the heart the extent of which may range from a slight disturbance of cardiac function (commotio cordis) to laceration of cardiac tissue and rupture of the myocardium. Enlargement of the mediastinum after a sufficiently forceful chest trauma should be examined by visualization of the aortic arch to elucidate its aetiology and exclude an aortic aneurysm. The mortality of chest trauma involving the mediastinal structures is 35%. This fairly high figure is partly attributable to severe accompanying injuries.

Adult↗