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Biomedical subjects

H Schöttke

Publications and source records attributed to H Schöttke.

6 recordsLinked to original sources
PubMed2005

[Which schizophrenic patients improve under work therapy, which ones don't?].

This investigation is part of a multicenter study, where only small effects and no superiority compared to creative ergotherapy was found for four weeks of inpatient work therapy. The criteria were three scales of the Osnabrück-Working Capabilities Profile (O-AFP) assessing basic learning ability, social communication ability and adaptation at the work place. The goal of this investigation is to identify subgroups of patients within the work therapy group, which differ in their course of ability level during the intervention. Three subgroups were identified for each scale. Subgroups with improvements comprise 24 % (learning ability) and 15 % (social communication) of the sample. Adaptation level decreases in a group of 9 % of the patients. The remaining clusters show constancy of abilities at different levels. Comparison of the clusters with neurocognitive, symptom and motivational variables shows that for learning ability mainly neurocognitive variables yield salient differences, whereas for social communication abilities, symptoms and motivation, together with a specific aspect of memory, seem to be characteristic. Only positive symptoms are related to adaptation. Also, there are hints for variables that specifically characterize patients with improvement of ability level. The discussion deals with issues of assessment and prognosis in rehabilitation, contributions to the neurocognitive theory of schizophrenia and to the development of person-centered interventions.

Adaptation, Psychological↗
PubMed1990

[Coping with illness as conforming to technological rules: an analysis of coping behavior of schizophrenic patients].

Coping can be conceptualized in terms of conformity with certain rules describing the relation between appraisals (here: control-ability and variability of stressors) and coping behaviour (here: problem-oriented, non-problem-oriented). The goal of the study is to examine the relevance of this approach for the analysis of schizophrenic patients' coping with their disease. This was done with the help of a reanalysis of data from a previous study. Subjects were 40 patients, which could be grouped in three clusters: high symptom strain, low symptom strain, specific strain (prodromal). Results showed that patients with low strain had a higher level of rule-conformity. Also, subjects with high rule conformity had a higher level of well-being, better prognosis and a higher level of professional education.

Adaptation, Psychological↗
PubMed1990

[Differential diagnosis of destructive processes of the skull base. Aggressive polypoid eosinophilic pansinusitis with expression of carcinoembryonic antigen (CEA)].

We report a woman with extensive polypoid sinusitis and bony destruction of the middle and posterior skull base. Histological examination of the specimen from the paranasal sinuses and adjacent skull base revealed polypoid eosinophilic sinusitis: malignancy could be excluded histologically and clinically. Plasma-CEA-levels were elevated to 85 micrograms/l with no typical source of CEA expression, and they fell after therapy. Immunocytochemistry revealed a remarkable expression of CEA in the surface epithelia of the specimen obtained from the paranasal sinuses. CEA-immunoscintigraphy showed an enhancement in the regions of the paranasal sinuses without expression elsewhere in the body. The authors discuss the possibility of using CEA as a marker for aggressive forms of chronic sinusitis and suggest radiotherapy is a successful treatment option in addition to surgery. The observation period of almost two years confirms the value of the chosen therapy.

Adult↗
PubMed1988

[Personal experiences with tympanoscopy in sudden deafness].

The rupture of the round window membrane with consecutive perilymph fistula has gained in importance in the discussion of the pathogenesis of sudden hearing loss. In a retrospective study, the results of 23 tympanoscopies performed at the ENT Department of the University of Hamburg are reported. Two confirmed perilymph fistulas were seen, whereas in three cases they could not be excluded. After obliteration of the window niches with connective tissue an improvement of the hearing loss was seen in 9 cases. In comparison with our intraoperative findings, the number of perilymphatic fistulas mentioned in literature often seems very high. Nevertheless, tympanoscopy and obliteration of the window niches have their definite place in the therapeutic concept of sudden hearing loss, although the indication must be severely restricted.

Adolescent↗
PubMed1984

Effect of low-molecular-weight proteins on protein (lysozyme) binding to isolated brush-border membranes of rat kidney.

Filtered proteins including the low-molecular-weight protein lysozyme are reabsorbed by the proximal tubule via adsorptive endocytosis. This process starts with binding of the protein to the brush-border membrane. The binding of 125I-labelled egg-white lysozyme (EC 3.2.1.17) to isolated brush-border membranes of rat kidney and the effect of several low-molecular weight proteins on that binding was determined. The Scatchard plot revealed a one-component binding type with a dissociation constant of 5.3 microM and 53.0 nmol/mg membrane protein for the number of binding sites. The binding of the cationic lysozyme was inhibited competitively by the addition of cationic cytochrome c to the incubation medium, while the neutral myoglobin had no effect. The anionic beta-lactoglobulin A inhibited the lysozyme binding in a noncompetitive manner. These data suggest that the binding takes place between positively charged groups of the protein molecule and negative sites on the brush-border membrane, and, the competition between the cationic cytochrome c and the cationic lysozyme for the binding sites may be responsible for the inhibitory effect of cytochrome c on renal lysozyme reabsorption. The binding step at the brush-border membrane appears to be cation-selective.

Animals↗