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Biomedical subjects

H Satoh

Publications and source records attributed to H Satoh.

At least 1,027 records · Page 57Linked to original sources
PubMedDate not supplied

Lung cancer in the octogenarian.

BACKGROUND: Older patients with lung cancer tend to have significant coexisting diseases and less aggressive treatment is often advisable. OBJECTIVE: To investigate the clinicopathological features of lung cancer in patients aged 80 years and over. METHODS: The medical records of 966 patients with lung cancer between 1976 and 1999 were reviewed retrospectively. RESULTS: There were 56 (5.8%) patients 80 years old or over. Thirty-nine (70%) were male, and 22 (39%) patients had poor performance status (2-4). Some of the patients had a medical history of cardiovascular disease (n = 23; 41%), cerebrovascular disease (n = 5; 9%), diabetes mellitus (n = 11; 20%), or malignant disease (n = 8; 14%). Twenty-one (35%) patients were diagnosed as having surgically resectable disease and 20 patients underwent radiotherapy, but 25 patients only received supportive care because of concomitant illnesses. Only 9 and 2 patients, respectively, had chemotherapy and surgery. There was no statistical difference in the survival rate of the two groups of patients receiving radiotherapy or supportive care. CONCLUSION: Adequate palliative care to provide prolonged quality survival is an appropriate primary goal of therapy for lung cancer in the octogenarian until less invasive treatments are developed.

Age Factors↗
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SHIN, a low frequency red cell antigen, found in two Japanese blood donors.

A low frequency red cell antigen, SHIN, was detected in two Japanese blood donors. Red cells of the first propositus reacted, in pretransfusion tests, with the serum of a previously untransfused male patient. The second propositus was disclosed when anti-SHIN was used to screen red cells from 3,000 random blood donors in Tokyo: a frequency of 0.03% in this population. Family studies showed SHIN to be inherited as an autosomal dominant character and not to be part of the MNS, FY, JK or P1 blood group systems. Anti-SHIN is not a common antibody in normal sera but was found in about 10% of multispecific sera used in investigation of low frequency antigens.

Asian People↗
PubMedDate not supplied

Clinical evaluation of CYFRA 21-1 in malignant pleural fluids.

The diagnostic value of the novel tumor marker CYFRA 21-1 in malignant pleural fluid was assessed in comparison to carcinoembryonic antigen (CEA). CYFRA 21-1 and CEA were measured in pleural fluid obtained from patients with 108 malignant and benign diseases. The levels of pleural fluid CYFRA 21-1 in malignant diseases (median: 84.5 ng/ml) were statistically higher than those in benign diseases (median: 13.9 ng/ml; p < 0.01). The CYFRA 21-1 test was able to discriminate significantly between squamous cell lung cancer and pneumonia (p < 0.01), while pleural fluid CEA levels could not. Receiver operating characteristic (ROC) curve analysis showed that the CYFRA 21-1 test has an advantage over CEA because of its higher specificity. These results indicate that measurement of CYFRA 21-1 in pleural fluid is a new tool, in addition to cytologic examination, to discriminate between malignant and benign diseases.

Adult↗
PubMedDate not supplied

Comparison of urine cytology between the ileal conduit and Indiana pouch.

OBJECTIVE: To compare the cytomorphologic features of urine obtained from two different kinds of urinary diversions constructed after total bladder resection. STUDY DESIGN: The smears of urine from 11 ileal conduits and 6 Indiana pouches were evaluated. All patients underwent total bladder resection due to transitional cell carcinoma (TCC) or other kinds of cancer before urine diversion. RESULTS: The cytologic features of Indiana pouch urine include degenerated, small, round cells without columnar cells derived from intestinal epithelium. In ileal conduit urine, well-preserved columnar cells and degenerated, small, round cells were frequently observed. The columnar cells in ileal conduit urine exhibited cytologic features that should be distinguished from TCC cells. CONCLUSION: The method of reconstructing the urinary tract is important in urine cytology from urine diversions because the cytomorphologic features of urine are different between the two kinds of urinary diversions. Since columnar cells in ileal conduit urine might lead to misdiagnosis as TCC, special consideration is required to examine ileal conduit urine.

History, 16th Century↗
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Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects.

Bay K 8644, an L-type Ca2+ channel agonist, was shown previously to increase resting sarcoplasmic reticulum (SR) Ca2+ loss and convert post-rest potentiation to decay in dog and ferret ventricular muscle. Here, the effects of Bay K 8644 on local SR Ca2+ release events (Ca2+ sparks) were measured in isolated ferret ventricular myocytes, using laser scanning confocal microscopy and the fluorescent Ca2+ indicator fluo-3. The spark frequency under control conditions was fairly constant during 20 s of rest after interruption of electrical stimulation. Bay K 8644 (100 nmol/L) increased the spark frequency by 466+/-90% of control at constant SR Ca2+ load but did not change the spatial and temporal characteristics of individual sparks. The increase in spark frequency was maintained throughout the period of rest. The increase in Ca2+ spark frequency induced by Bay K 8644 was not affected by superfusion with Ca2+-free solution (with 10 mmol/L EGTA) but was suppressed by the addition of 10 micromol/L nifedipine (which by itself did not alter resting Ca2+ spark frequency). This suggests that the effect of Bay K 8644 on Ca2+ sparks is mediated by the sarcolemmal dihydropyridine receptor but is also independent of Ca2+ influx. Low concentrations of caffeine (0.5 mmol/L) increased both the average frequency and duration of sparks. Ryanodine (50 nmol/L) increased the spark frequency and also induced long-lasting Ca2+ signals. This may indicate long-lasting openings of SR Ca2+ release channels and a lack of local SR Ca2+ depletion. In lipid bilayers, Bay K 8644 had no effect on either single-channel current amplitude or open probability of the cardiac ryanodine receptor. It is concluded that Bay K 8644 activates SR Ca2+ release at rest, independent of Ca2+ influx and perhaps through a functional linkage between the sarcolemmal dihydropyridine receptor and the SR ryanodine receptor. In contrast, caffeine and ryanodine modulate Ca2+ sparks by a direct action on the SR Ca2+ release channels.

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethy↗
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Pituicytoma: primary astrocytic tumor of the pars nervosa in aging Fischer 344 rats.

We describe 2 cases of a relatively rare tumor diagnosed as pituicytoma in the pars nervosa of rat pituitary. This tumor was spontaneously noted in one 110-week-old female and one 109-week-old male Fischer 344 (F344)/DuCrj rats during 2-year carcinogenicity studies. Although no gross abnormality of the pituitary was detected in the female rat, whitish discoloration and enlargement of the pituitary were observed in the male. Histopathologically, neoplastic cells in both animals possessed pale eosinophilic, often abundant irregular cytoplasm with nuclei of variable size. The tumor cells were arranged in the spindle or sheet cell pattern with indistinct cell boundaries and showed compression or invading proliferation of surrounding tissues. Prominent pleomorphism of the cells was noted in the tumor in the female rat, and mitotic figures were detected in several portions of the tumor in the male rat. Small-sized cells having scanty cytoplasm with deeply staining nuclei seen in the mass were suspected to be microglia. Moreover, isolated single native pars distalis cells were distributed throughout the tumor masses. Immunohistochemically, cytoplasmic foot process of the tumor cells showed a positive immunoreactivity for glial fibrillary acidic protein. On the basis of morphologic characteristics and glial fibrillary acidic protein staining, this tumor is consistent with astrocytoma.

Aging↗
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Invasive pituitary tumors in female F344 rats induced by estradiol dipropionate.

To clarify the histopathological progression of invasive tumors in the pituitary pars distalis due to estrogen, female Fischer 344 (F344) rats were treated subcutaneously with 5 mg/animal of estradiol dipropionate (ED) once every 2 wk for 13 wk. The animals were killed serially at 2-wk intervals during the investigation. The pituitaries with surrounding tissues were examined light microscopically. At week 7, pituitary cells showed proliferation and atypia with formation of blood-filled spaces. Lesions with these characteristics were diagnosed as adenomas. At week 9 or later, neoplastic cells exhibited extensive proliferation and infiltration into the surrounding tissues, suggesting development of carcinoma. Both proliferating cell nuclear antigen (PCNA) and 5-bromo-2'-deoxyuridine (BrdU) labeling index, markers of cell proliferation, were significantly increased in animals with adenoma or carcinoma. To detect sequential changes in pituitary weight, its signal intensity was periodically monitored in identical rats by using magnetic resonance (MR) imaging. The estimated pituitary weights revealed by MR imaging were comparable to the tumor weights obtained from rats at scheduled sacrifices. These results indicate that ED possesses the potential to cause carcinoma in rat pituitary and MR imaging is an effective tool for estimating the pituitary weight.

Adenoma↗
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Influence of altered middle ear pressure on cochlear microphonics.

Patients with otitis media with effusion often have impaired hearing loss caused by bone conduction. Among several possible causes for this hearing loss, the influence of middle ear pressure upon hearing was examined. Cochlear microphonics (CM) of guinea pigs were recorded under positive or negative pressure created simultaneously in the middle ear and in the external ear canal. CM was recorded from each turn (basal, second, third and apical). Whereas under negative pressure CM decreased suddenly but soon became stable, under positive pressure CM normalized gradually after the initial drop. Thus, in the stable state, CM amplitude was low under negative pressure but was slightly subnormal under positive pressure. One possible explanation is that perilymphatic efflux appears to cause such recovery of CM under positive pressure. it is postulated that perilymphatic inflow does not seem to occur under negative pressure, since CM and perilymphatic pressure were stable.

Animals↗
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Clinical significance of nocturnal blood pressure monitoring.

Although there are certain technical problems in determining nocturnal BP by ambulatory BP monitoring, the information provided on nocturnal BP has possible clinical significance. Short-term BP variability, an elevated BP during sleep and amplitude and sleep of nocturnal BP decline might be responsible for cardiovascular mortality. Furthermore, circadian BP variation might also be responsible for cardiovascular morbidity and mortality. The nocturnal BP level, even in extreme dippers with diurnal hypertension, is equivalent to or higher than that in normotensive subjects. Antihypertensive effects of drugs with different pharmacologic properties positively correlate with basal ambulatory BP. Therefore, there is a critical BP level at which the antihypertensive effect disappears. The critical BP level for each drug is in normal BP range but not in the hypotensive range. Therefore, an antihypertensive regimen would be safe even in extreme-dipper hypertension without excessive nocturnal hypotension, and might even be beneficial because of the decreasing amplitude and speed of the nocturnal BP decline. We conclude that an antihypertensive drug regimen should control BP throughout a 24-h period regardless of circadian BP variation.

Antihypertensive Agents↗
PubMedDate not supplied

Does earlier detection of lung cancer on mass screening improve outcome in younger and middle-age patients?

In order to demonstrate clinicopathological features, especially in relation to the detection of lung cancer in younger (<40 years) and middle-aged patients, a total of 850 patients with lung cancer were analyzed with reference to their basis for detection. Asymptomatic patients in their forties and fifties diagnosed on mass screening had higher prevalence rate of surgically resectable disease and better three-year survival compared with patients who required medical attention because of symptoms. Our results suggest that mass screening for patients under the age of 50 years does not change the outcome, however, patients in the age group 50-59 years receive some benefit in our screening system.

Adenocarcinoma↗
PubMedDate not supplied

Diagnostic procedures in obtaining pathological materials for pulmonary nodules due to primary lung cancer.

This study analyzed the diagnostic procedures of 391 patients with a pulmonary nodule due to lung cancer encountered in the practice from 1987 to 1997. Transbronchial biopsy and cytological procedures under fiberoptic bronchoscopy made a diagnosis in 329 (84.1%) of the patients. In 266 patients with endoscopically invisible tumor, transbronchial biopsy gave a positive result in 74.1% and the rest were diagnosed by cytological procedures. Transbronchial biopsy with cytological procedures should be considered as the initial diagnostic procedure. The most appropriate method and combining methods can improve the diagnostic yield in patients with pulmonary nodules.

Adenocarcinoma↗
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Long-term cure of a malignant lymphoma of the pleural cavity treated by irradiation.

Malignant lymphomas arise in the pleura in association with a long-standing chronic tuberculous pyothorax. We report a case of a non-Hodgkin's lymphoma of the pleural cavity, inoperable because of local invasion into thoracic wall, who has survived more than 6 years without recurrence. This patient represents the longest reported survival after radiation therapy alone. Radiotherapy holds an important role in the treatment of locally advanced lymphoma of the pleural cavity.

Aged↗
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Intracranial hemorrhage due to cerebral metastasis of lung cancer - a case report.

Lung cancer often metastasizes to brain. However, hemorrhage of the metastatic lesions is uncommon. We report a case of a 68-year old man with lung cancer who underwent right upper lobectomy of the lung and presented in 15 months with a cerebral hemorrhage from a metastatic lesion of the brain.

Adenocarcinoma, Papillary↗
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Unilateral metachronous lung cancers in a patient with idiopathic pulmonary fibrosis.

The incidence of lung cancer in patients with idiopathic pulmonary fibrosis is much higher than that in general population. We report on a case of large cell carcinoma in association with the additional occurrence, seven months later, of an adenocarcinoma of the lung. Surgical treatment was performed for each cancer, however, the outcome was poor. The association between the two disorders is discussed.

Adenocarcinoma↗
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Atypical presentation of vertebral bone metastasis from lung cancer.

The authors describe a case of lung cancer in a 55-year-old man who complained of back pain. Initial isotopic bone scanning showed no abnormality, however, magnetic resonance (MRI) imaging revealed bone metastasis in thoracic vertebral bone. Even when there is no typical findings of metastasis in bone scintigraphy, MRI imaging would be useful if vertebral bone metastasis is suspected. MRI imaging is an important modality to evaluate extraosseous extension and marrow invasion of metastatic tumors.

Carcinoma, Large Cell↗
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Patterns of brain metastasis in lung cancer.

Brain metastasis as the only site of spread in lung cancer was studied. Ninety-two (13.1%) of 701 lung cancer patients had brain metastasis at the time of diagnosis. Eighteen and 16 patients had small primary lesion and were N0-1 disease, respectively. Thirty-two patients had sole brain metastasis. Patients with sole brain metastasis had more favorable survival than patients with other metastatic sites (p=0.0165). Brain metastasis may occur even with small primary lesion and/or without regional lymph node involvement. Well-planned surgery or stereotactic radiosurgery will result in enhanced survival.

Adenocarcinoma↗
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Lung cancer in middle-aged patients.

Clinicopathological features of middle-aged lung cancer patients were investigated in 1016 consecutive patients. Among them, 22.8% of patients were in their forties and fifties. The preponderance of adenocarcinomas and the higher female/male ratio in middle-aged groups compared with the older group were findings similar to those observed in younger patients. Smoking habit increased according to the age groups. Middle-aged patients had a propensity for advanced stage, however, survival was not inferior to younger patients. Middle-aged patients consisted of two different groups of patients, whose characteristics were similar to those observed in either younger or elderly patients.

Adenocarcinoma↗