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Biomedical subjects

H Satoh

Publications and source records attributed to H Satoh.

At least 577 records · Page 32Linked to original sources
PubMed1993

Drinking habits influence the relationship between apolipoprotein AII and body mass index.

The relationships of cigarette smoking, exercise, and body mass index (BMI) to the serum levels of high-density lipoprotein (HDL) cholesterol, apolipoprotein AI (Apo AI), apolipoprotein AII (Apo AII), and % of HDL cholesterol to total cholesterol (%HDL-C) were assessed in 495 employees of a telephone company in Japan. They were subdivided into four groups by frequency of alcohol intake: nondrinkers (n = 28), those who drank once per week (n = 78), those who drank 2 to 5 times per week (n = 245), and those who drank 6 to 7 times per week (n = 144). Although univariate analysis before grouping showed a positive correlation between Apo AII and BMI, multiple analysis examined in each group showed the positive relationship only in the nondrinking group. The relationship between BMI and Apo AII would thus appear to depend on drinking habits.

Adult↗
PubMed1993

[Changes of bone marrow MRI pattern in aplastic anemia before and after bone marrow transplantation].

In order to evaluate the usefulness of magnetic resonance imaging (MRI) in estimating bone marrow cellularity, we performed T1-weighted MRI of the lumbar vertebral marrow in two patients with severe aplastic anemia, before and after bone marrow transplantation (BMT). High signal intensity was detected in the bone marrow before BMT, but the bone marrow pattern of MRI became normal after BMT. MRI seems to be effective for evaluating bone marrow cellularity and recovery, and for monitoring therapeutic effects in patients with aplastic anemia before and after treatment with BMT.

Adult↗
PubMed1993

[Screening of obese or lean schoolchildren; difficulty in applying "the Japanese weight and height standards for estimating over- and under-weight" to younger people].

Obesity or leanness of an individual tends to continue from childhood to adult ages. It is therefore desirable to establish a single standard for obesity/leanness that is applicable throughout these stages of life. Trials were made in the present study to examine if 'the Japanese weight and height standards for estimating over- and under-weight' (established for adults by the Ministry of Health and Welfare of the Government of Japan) is applicable also to younger people. The standard is developed with two assumptions that both height and logarithm of weight distribute normally. The height and weight of about 83,000 6th-grade children in primary schools (12 years of age; with boys and girls of an equal number), and about 78,000 3rd-year-children in junior high schools (15 years of age) were available. The analyses of the data disclosed that, whereas height distributes normally, their weight does not fit with normal distribution when converted logarithmically or even when the conversion is made after subtraction of a constant value from the weight. The distribution pattern of weight of children was however essentially the same, independent of height. Thus, it was possible to classify the children into five categories of definitely obese (10%), tending toward obesity (15%), normal (50%), slim (15%) and thin (10%) groups with the same statistical parameters, regardless of their height excluding extremely tall or short cases.

Adolescent↗
PubMed1993

[A case of left atrial myxoma with acute myocardial infarction--emergency coronary artery bypass grafting and removal of left atrial myxoma].

A 68-year-old woman had clinical signs of an acute myocardial infarction. Echocardiography revealed a tumor in the left atrium. Coronary angiography demonstrated total occlusion at RCA#1. On emergency operation a left atrial myxoma was removed and aortocoronary saphenous vein graft to the right coronary artery was performed. The operative correction of coronary arterial obstruction due to cardiac myxoma or thrombus is rare.

Aged↗
PubMed1993

[Venous thrombosis after closed head injury: a report of two cases presenting as intracranial hypertension].

Although sinus thrombosis occurs owing to various causes, sinus thrombosis after closed head injury is rarely reported. The authors encountered 2 cases with sinus thrombosis in whom intracranial hypertension occurred after closed head injury. In case 1, left abducens and oculomotor palsy developed as a false localizing sign, together with symptoms of intracranial hypertension 10 days after head injury. Using angiography, we made a diagnosis of stenosis of the superior sagittal sinus. Since the symptoms were aggravated under conservative treatment, V-P shunt was performed, but impaired vision was not improved. In case 2, symptoms of intracranial hypertension occurred 10 days after head injury. We performed magnetic resonance angiography (MRA) and made a diagnosis of stenosis of the bilateral transverse sinuses. The symptoms improved under conservative treatment. The use of conventional angiography has been the most reliable for a diagnosis of sinus thrombosis, but MRA will become useful from now on. For diagnosis, it is important to suspect sinus thrombosis after closed head injury. Surgical decompression is required for patients in whom symptoms are aggravated under conservative treatment.

Child↗
PubMed1993

[Injury of pulmonary artery and intrathoracic artery--a surgical case report].

The patient was a 52-year-old man. Tube drainage was performed to the right traumatic hemothorax. Then, 2,000 ml of blood flowed out and bleeding stopped for a time. Four hours later after injury, massive bleeding occurred again. So emergency thoracotomy was performed and we found a laceration in the main pulmonary artery and injury of intrathoracic artery. Pulmonary artery disruption from blunt chest trauma is rare. Further discussion was made by reviewing the related literature.

Accidents, Traffic↗
PubMed1993

[A combined operation of aortic valve replacement and bullectomy for aortic valve stenosis and giant bulla].

A 61-year-old male with aortic valve stenosis and giant bulla, whose respiratory function was very poor, successfully underwent a combined operation of aortic valve replacement and bullectomy. Firstly aortic valve replacement was performed under cardio-pulmonary bypass, and after coming off bypass, giant bulla was resected via median sternotomy. Postoperative respiratory function was improved remarkably (VC: per-op 1.89 l, post-op 2.53 l, FEV1.0: pre-op 0.74 l, post-op 1.13 l) and also his clinical symptom improved from Hugh-Jones IV. to I. postoperatively.

Aortic Valve↗
PubMed1993

[Results of 29-year study of hoya (sea-squirt) asthma in Hatsukaichi, Hiroshima prefecture].

As remarkable improvements have been made to the working environment and working methods of oyster shucking workers during the past 30 years, a study was made on the effects of these improvements on hoya (sea-squirt) asthma and the following results were obtained. 1) The prevalence of hoya (sea-squirt) asthma among oyster shucking workers was 36.0%, 30.1%, 21.7%, 22.0%, 18.0%, and 26.6% in 1963, 1968, 1976, 1984, 1988, and 1992, respectively. Accompanying the improvements made to the working environment and working methods, asthmatic symptoms failed to develop in some of the patients through engaged in oyster shucking work. Thus, those with symptoms actually accounted for 36.0%, 18.7%, 15/8%, 7.4%, 8.4%, and 8.0% of the workers, respectively. 2) The proportion of serious cases among the patients rapidly decreased from 29.2% in 1963 to 0% after 1984. On the other hand the proportion of slight cases was 35.4% in 1963, but after 1988 all the cases were slight cases. 3) During the period from 1984 to 1992, the number of those newly engaged in oyster shucking work was 74. The number of those who developed hoya (sea-squirt) asthma during this period was 8 or 10.1%. All the cases were asthma of the rhinitis type. 4) The number of workers who did not develop asthmatic symptoms though engaged in oyster shucking work was 53 in 1984, 40 in 1988, and 49 in 1992. Of this number, 31% are now under hyposensitization therapy, 57.0% have received this therapy in the past, and 12.0% have not received any therapy.

Animals↗
PubMed1992

Taurine inhibition of fast Na+ current in embryonic chick ventricular myocytes.

Effects of taurine on the fast Na+ current (INa) in 17-day-old embryonic chick ventricular myocytes were examined using the whole-cell voltage-clamp technique. The cells were spherical (10-15 microns diameter) and had a capacitance of 9.8 +/- 1.3 pF. The experiments were performed at room temperature (22 degrees C), and the holding potential was -90 mV. After the patch membrane was broken, peak INa initially increased, and then decreased and became stable within 3-5 min. The experiments on taurine were started after INa had stabilized. The characteristics of INa were as expected, including sensitivity to tetrodotoxin (10 microM). When added to the bath, taurine inhibited INa and shifted the reversal potential in the hyperpolarizing direction. At 10 mM, taurine inhibited INa by 38.2 +/- 4.3%, and shifted the reversal potential by 10.2 +/- 3.1 mV. The time to peak current was slowed: 0.83 +/- 0.20 ms (n = 11) in control, 1.03 +/- 0.18 ms (n = 9) in 10 mM taurine, and 1.10 +/- 0.19 ms (n = 10) in 20 mM taurine. These effects of taurine were not reversed by 30 min washout. At low concentrations, taurine actually enhanced INa in 3 of 8 cells at 1 mM, and in 4 of 10 cells at 5 mM; the reversal potential was still shifted in the hyperpolarizing direction by 5.7 +/- 1.6 mV. The time course of inactivation (fitted as a single exponential at test potential of -30 mV) was not affected: 1.1 +/- 0.5 ms in control 1.2 +/- 0.4 ms at 10 mM taurine.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1992

Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride.

The effects of two dihydropyridine type calcium entry blockers, nilvadipine and nicardipine hydrochloride (nicardipine), on the liberation of free fatty acids (FFAs) were investigated using an experimental model of global cerebral ischemia in rats, and were compared with their pharmacokinetic properties. Nilvadipine, but not nicardipine, at a dose of 100 micrograms/kg i.v., significantly attenuated the liberation of FFAs, particularly docosahexaenoic and arachidonic acid. Furthermore, the brain concentration of nilvadipine was higher than that of nicardipine after equivalent dosing. The results of the present study demonstrate that pharmacokinetic differences between these two calcium entry blockers might explain the difference in their pharmacological efficacy.

Animals↗
PubMed1992

Reduced dietary cadmium intake in past 12 years in a rural area in Japan.

To examine possible reduction in dietary cadmium (Cd) intake, 24-h duplicates of diet were collected twice in the same village in north-eastern Japan, once in 1976-1977 (71 samples) and then in 1989 (198 samples) and analyzed for Cd contents. The statistical analysis by sex and age decade showed that there has been a significant (P less than 0.01-0.05, depending on sex and age) reduction in Cd intake during this 12-year period. The intake by men at 30-59 years was 28.8 micrograms/day (as a geometric mean of 41 samples) in 1976-1977 and 20.8 micrograms/day in 1989, indicating some 28% reduction, whereas the value for women of the same age range was 24.9 micrograms/day in 1976-1977 and 15.7 micrograms/day in 1989, with a reduction by 37%. A similar reduction in Cd contents was observed in cooked rice samples collected in 1980 and 1990 in the vicinity of the study field. Probable reasons for the improvement are discussed.

Adult↗
PubMed1992

Growth and transformation suppressor genes for BHK Syrian hamster cells on human chromosomes 1 and 11.

To map putative tumor suppressor genes for the near-diploid baby hamster kidney fibrosarcoma cell line BHK, we transferred five different normal human chromosomes (1, 3, 7, 11, and 12) into these tumor cells by microcell-mediated chromosome transfer. Transfer of human chromosome 1 into BHK cells resulted in suppression of cell growth both on plastic and in soft agar, indicating that chromosome 1 has a generalized effect on cell growth and thereby suppresses anchorage-independent growth. Selection against cells with an intact chromosome 1 was observed. In contrast, the introduction of chromosome 11 into BHK cells resulted in suppression of anchorage independence but not growth on plastic. Most chromosome-11 growth-suppressed BHK hybrids retained intact copies of human chromosome 11. Tumorigenic derivatives of chromosome 11 hybrids had lost this chromosome. Transfer of human chromosome 3, 7, or 12 into BHK cells did not correlate with growth suppression of BHK cells on plastic or in soft agar. Thus, we conclude that genes that suppress BHK-cell growth in general or in agar reside on human chromosomes 1 and 11, respectively.

Animals↗
PubMed1992

Long-term survival of human myeloid progenitor cells induced by a mouse bone marrow stromal cell line.

Mouse endothelial-adipocyte cell line (14F1.1), which induces proliferation of mouse stem cells in culture, is also capable of supporting long-term survival in culture of human myeloid progenitor cells; colony forming unit-granulocyte/macrophage (CFU-GM) was recovered from cultures incubated with the 14F1.1 cell line after over a month of incubation. The CFU-GM population increased beyond the input number, whereas, in control cultures initiated without stromal cells, the number of progenitors gradually declined. Addition of a relatively low concentration of human colony-stimulating factors (CSFs) into the cultures promoted the formation of "cobblestone areas," where mouse stroma and human hemopoietic cells closely interacted. 14F1.1 supernatant alone did not support the survival of human CFU-GM but synergized with the function of human granulocyte-macrophage colony-stimulating factor (GM-CSF) to stimulate adherent macrophage proliferation.

Animals↗
PubMed1992

Taurine effects on ionic currents in myocardial cells.

The effects of taurine on the slow and fast Na+ currents and slow and fast Ca2+ currents in cultured single ventricular cells from young (3-day-old) and old (10, 17 day) chick embryos were studied using the whole-cell voltage clamp technique. In single 3-day cells that showed only a TTX-insensitive fast (transient) Na+ current (INa(f)), taurine (5 mM) rapidly increased the amplitude of this current. In single cells that showed only a typical slow (sustained) Na+ current (INa(s)), taurine (5 mM) induced a fast transient component. A slow Ca2+ current (ICa(s)) was also present in the 3-day-old embryonic chick cells, and taurine inhibited this current and activated a fast transient component (ICa(f)). Taurine had similar actions in 10-day-old embryonic heart cells. Thus, in embryonic chick heart cells, taurine stimulates the TTX-insensitive fast transient Na+ current and blocks the slow component. Taurine also activates a fast (transient) component of the Ca2+ current (ICa(f)). The activation of the TTX-insensitive INa(f) may increase Ca2+ influx via Na(+)-Ca2+ exchange. This may explain, in part, the positive inotropic effect of taurine in heart muscle, with relatively little effect on the Ca(2+)-dependent slow APs. Taurine (10 or 20 mM) added to the outside markedly inhibited TTX-sensitive INa, but slightly stimulated INa when added internally. ICa(s) and IK both were stimulated by external taurine at pCa 10 but inhibited at pCa 7. Taurine also inhibited IK in aortic VSM cells. In contrast, taurine induced or stimulated ICa(f). Elevation of [Ca]i was induced by taurine. The elevation may result from the enhancement of ICa(f) and possibly of Na(+)-Ca2+ exchange, resulting in a positive inotropic effect. It has been shown that in neurons, taurine increases the Cl current, resulting in hyperpolarization (Taber et al., 1986; Figure 12). Thus, taurine effects are complex, there being a number of actions on the membrane currents of cardiac cells, vascular smooth muscle cells, and neurons.

Action Potentials↗
PubMed1992

Complementation of a DNA repair deficiency in six human tumor cell lines by chromosome 11.

Human tumor cells, after x-irradiation during the G2 phase of the cell cycle, show an abnormally high frequency of persistent chromatid breaks and gaps resulting from deficient DNA repair. Addition of a single human chromosome 11 from normal fibroblasts by micro-cell fusion to cell lines from six different tumors resulted in efficient repair of the radiation-induced damage to the level in normal cells. For one of the cell lines, addition of the long arm of chromosome 11 was sufficient to restore repair efficiency. In four of the six tumor lines, restoration of efficient DNA repair by chromosome 11 was associated with tumor suppression in nude mice. These results suggest that chromosome 11 carries a DNA repair gene or genes that complement the repair deficiency of tumor cells and that this gene for at least one tumor is localized to the long arm.

Carcinoma, Renal Cell↗
PubMed1992

Increased urinary cadmium excretion and its relationship to urinary N-acetyl-beta-D-glucosaminidase activity in smokers.

To assess the renal effects of low-level exposure to cadmium due to smoking we examined blood and urinary levels of cadmium and urinary excretions of N-acetyl-beta-D-glucosaminidase (NAG), beta 2-microglobulin (BMG) and metallothionein in 94 male workers aged 18-55 years. Both blood and urinary cadmium levels indicated excess exposure to cadmium caused by smoking. The urinary cadmium concentration ranged between 0.1 and 5.0 micrograms/g creatinine and increased significantly with age in the smokers. Neither urinary NAG nor BMG was increased in the smokers compared from non-smokers. A positive relationship between urinary cadmium and metallothionein was obtained not only in the smokers but also in the non-smokers. Furthermore, in the smokers urinary cadmium and metallothionein was positively related with urinary NAG. Since NAG in urine mostly originates from tubular cells by lysosomal exocytosis, the results may reflect an early cadmium effect on the lysosomal functions. Inhibitory effect of cadmium on the lysosomal degradation activities was discussed as a possible explanation of the positive relationship of urinary cadmium and metallothionein to urinary NAG.

Acetylglucosaminidase↗
PubMed1992

Polyclonal activation of human lymphocytes and induction of cytotoxic lymphocytes by streptococcal preparations.

Polyclonal activation of human peripheral blood lymphocytes (PBLs) in vitro by preparations of Streptococcus pyogenes Su strain (OK-432) and other heat-killed strains was investigated. The streptococcal preparations tested induce a proliferative response of PBLs via interleukin-2 (IL-2)-independent pathways. The proliferative response is accompanied by the generation of lymphoblastic cells (LBCs), which consist of heterologous lymphocyte populations: CD4+ helper type of T cells, and CD4-CD8- double-negative (DN) lymphocytes, including both CD3+ TcR gamma + T cells and CD2+CD3- immature type of T or non-T cell type of lymphocytes. Almost all the LBCs express Leu19, TfR (transferrin receptor), LFA-1 and CD38 (OKT10) antigens, which are expressed on activated T cells, NK cells and some other lymphocytes. The proliferative response of human PBLs is also accompanied by the generation of potent cytotoxic activity against NK-sensitive and -resistant targets. C-dependent cytolysis and cell sorting experiments of OK-432-activated LBCs revealed that both CD3+ and CD3- types of CD4-CD8- DN lymphocytes, but not CD4+ helper T cells, may be major populations responsible for the cytotoxicity induced. On the other hand, CD4-CD8- T cells may be required for the proliferation of PBLs and generation of cytotoxic effector cells. These results suggest that the OK-432 and other streptococcal preparations stimulate the human PBLs in vitro to induce the proliferation/activation of CD4+ T cells, mediating the following generation of DN cytotoxic effector lymphocytes.

DNA Replication↗