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Biomedical subjects

H Sahebjami

Publications and source records attributed to H Sahebjami.

42 records · Page 3Linked to original sources
PubMedDate not supplied

Lung tissue elasticity during the lifespan of Fischer 344 rats.

Fischer 344 rats at 1 week, 6 weeks, 5 months, 14 months, and 22 months of age were studied. Lung wet and dry weights and lung volumes increased with age. As rats grew older, saline volume-pressure (V-P) curves expressed as percent maximal lung volume shifted progressively upward and to the left and tissue recoil decreased over the upper and mid portions of the V-P relationships. Specific lung compliance increased until 5 months of age but did not change afterward. DNA content of the lung increased progressively until 5 months of age but decreased in older rats. Protein content of the lung increased significantly with age, while hydroxyproline and crude connective tissue content of the lung increased progressively until 14 months of age. Decreased tissue recoil and increased lung volume and lung compliance with age, in face of an increase in connective tissue proteins, suggest that larger air space dimensions might be responsible for changes in lung mechanics in aging rats.

Aging↗
PubMedDate not supplied

Effects of food deprivation on experimental emphysema in obese rats.

Obese male rats, with an average body weight of 530 g (approximately 30 weeks old), received either pancreatic elastase (75 microns/100 g) or saline intratracheally and were divided into fed and starved groups. Starved rats were given one-third of their measured daily food consumption. All groups were studied 4 weeks after the initiation of starvation. In both elastase and saline exposed rats, the saline volume-pressure curves expressed as a percentage of maximal lung volume were similar in fed and starved groups. Mean linear intercept (Lm) and alveolar surface area (Sa) were not different between the control-fed and the control-starved rats. Lm was similar but Sa was significantly smaller in the elastase-starved compared with the elastase-fed groups. It is concluded that, in contrast to the aggravating affects of weight loss on experimental emphysema in adult nonobese rats, food restriction does not affect elastase-induced injury significantly in obese animals.

Animals↗