THE EFFECT OF COPPER SULPHATE ON THE LD-50 OF CYSTEAMINE AND NN-DIETHYLCYSTEAMINE AND ON TREMOR INDUCED BY THESE COMPOUNDS.
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Biomedical subjects
Publications and source records attributed to H SCHNIEDEN.
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The LD50 in mice for nicotine, (-)-nornicotine and allylnornicotine given intraperitoneally was respectively 10 mg/kg, 18.8 mg/kg and 93.3 mg/kg. Whilst nicotine inhibited the renal response in rats to water, (-)-nornicotine and allylnornicotine were without effect. Nicotine antidiuresis was not antagonized by (-)-nornicotine or by allylnornicotine.
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Levallorphan antagonizes the antidiuretic effect of morphine. It is at least 25 times as potent as nalorphine in this respect. However, neither levallorphan nor adiphenine antagonized the antidiuretic action of nicotine.
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The effect of a number of diuretic agents was investigated on rats with different degrees of expansion of extracellular fluid volume. With moderate saline loading aminoisometradine and chlorthiazide were the most efficient diuretics. However, with a more severe saline load aminoisometradine and mersalyl had the greatest effect while chlorthiazide had no significant diuretic activity. The action of acetazolamide seemed independent of the saline load. Potassium chloride showed no diuretic activity. Injecting the drugs in pairs resulted in probable potentiation only with acetazolamide plus chlorthiazide. Since all the diuretics were used in doses which gave maximal effects, the summation of the effects of the other pairs of diuretics suggested different sites of action.
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