[Studies on heterocyclic compounds. XXVIII. Synthesis of 5-(3-pyridyl)- and 5-(3-quinolyl) furfural derivatives (author's transl)].
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Furaldehyde↗
Biomedical subjects
H S Kuo
Publications and source records attributed to H S Kuo.
[Studies on heterocyclic compounds. XXVI. Preparation of 5-(3-pyridyl)-2-furaldehyde, 5-(3-quinolyl)-2-furaldehyde and these Schiff's bases (author's transl)].
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Furaldehyde↗
Poorer prognosis in young patients with gastric cancer?
BACKGROUND/AIMS: Although the relationship between prognosis and age of patients with gastric cancer is controversial, a poorer prognosis in young patients has been suggested by most investigators. To further examine the hypothesis, a retrospective study was undertaken to analyze a large series of patients with gastric cancer in Taiwan. METHODOLOGY: A total of 1,642 consecutive patients diagnosed with gastric cancer and receiving further management at one medical center from 1988 to 1993 were reviewed. The gender, TNM tumor stage, rate of curative resection and survival of the patients were compared in the young age group (< or = 39 years) and the old age group (> 39 years). Survival was estimated with the product-limit method and difference in survival was tested by the log-rank test. Multivariate analysis was done by the Cox proportional hazard model. RESULTS: Among the 1,642 patients, 61 patients were in the young age group and 1,581 patients were in the old age group. There was no significant difference for the 2 groups of patients in the distribution of TNM stage (stage I: 20%; II: 8%; III: 13%; IV: 59% vs. 19%, 11%, 25% and 45% respectively, in the old age group, p = 0.098) and rate of curative resection (38% vs 51% in the old age group, p = 0.059). The overall 5-year survival showed no significant difference between the 2 groups (25% vs. 29% in the old). Subgroup analyses showed that survival after curative resection and survival without curative treatment (including palliative resection and no resection) also had no difference in the 2 groups. Multivariate analysis also showed that age was not an independent factor. CONCLUSIONS: Although most reports suggested a dismal prognosis in young patients with gastric cancer, based on our findings, young patients (< or = 39 years) do not have a worse prognosis than older patients.
Adult↗
Intergenerational transmission of school-age parenthood.
A long-term follow-up of a group of black New Haven women who were young mothers in the late 1960s revealed that the majority of their offspring had not become parents by age 19. The offspring who experienced early parenthood were most likely to be female and to report significant depressive symptoms. Of those children--both male and female--who did become young parents, many were the offspring of women who had moved out of their mothers' homes within 26 months of the child's birth, and of women who reported suffering from lifetime depression. The data indicate that emotional deprivation, particularly at an early age, may predispose adolescents to seek emotional closeness through sexual activity and early parenthood.
Adolescent↗