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Biomedical subjects

H S Himal

Publications and source records attributed to H S Himal.

At least 73 records · Page 4Linked to original sources
PubMed1976

Gastric acid and serum gastrin secretion before and after bypass of the small intestine for morbid obesity.

Six obese patients undergoing end-to-side jejunoileal bypass had gastric acid output and serum gastrin measurements performed preoperatively and within three months postoperatively. Meat extract stimulated acid output was higher in obese than in normal patients. Following the bypass procedure, basal and meat extract stimulated acid output significantly decreased. Basal and meat extract stimulated serum gastrin levels did not change following bypass. These studies demonstrate that after a small intestinal bypass, acid output decreases. Gastrin plays no role in this change.

Clinical Trials as Topic↗
PubMed1976

A multiparametric computer analysis of carcinoma of the colon.

From 1957 to 1973, 656 patients with carcinoma of the entire colon, excluding those with carcinoma of the rectum, were reviewed with the aid of a computer. Of 457 patients, 69.7 per cent were observed for a minimum of five years. Sixty-five per cent of the lesions were located in the cecum or sigmoid colon. In patients with type A lesion, the five year plus survival rate was 71.15 per cent while, in patients with type D lesions, the five year plus survival rate was zero per cent. Patients who presented with intestinal obstruction had a significantly lower five year survival rate. Roentgenographic visualization of the cecum was significantly less accurate in demonstrating carcinoma when compared with that of the sigmoid colon. An emergency surgical procedure had a significantly higher operative mortality than did elective procedures. In both groups of patients undergoing emergency and elective operations, primary resection and anastomosis led to similar operative mortality rates, although staged procedures resulted in the lowest operative mortality in both groups. In the group of patients who had elective operations, resection an primary anastomosis led to a significantly lower wound infection and fistula rate when compared with the group of patients who had emergency procedures. In comparison with other series, no improvement in survival was illustrated in patients with carcinoma of the colon. The use of new modalities of adjuvant therapy, such as radiotherapy or chemotherapy, or both, actually should be evaluated.

Adult↗
PubMed1975

The management of bleeding acute gastric erosions: the role of gastric hypothermia.

Eighty-eight consecutive patients with bleeding acute gastric erosions were reviewed with the aid of a computer. Of the eroisons, 31-8 per cent were related to the ingestion of ulcerogenic drugs and 40-9 per cent were associated with surgery and sepsis. The overall mortality was 20-5 per cent. Endoscopy was the most effective diagnostic examination. Conservative management was effective in the treatment of bleeding erosions due to the ingestion of ulcerogenic drugs. Gastric cooling successfully arrested haemorrhage from bleeding erosions due to surgery and sepsis.

Acute Disease↗
PubMed1975

Duodenal obstruction related to benign biliary tract disease.

Duodenal obstruction in six patients was related to biliary tract disease and previous abdominal surgery. Causes of obstruction were adhesions to the inflamed gallbladder, adhesions to the gallbladder bed after cholecystectomy, intramural hematoma after transduodenal exploration of the common bile duct and severe pancreatitis after common bile duct exploration. Measures that may possibly prevent duodenal obstruction include early recognition and treatment of cholelithiasis, positioning of omentum between duodenum and gallbladder bed after cholecystectomy, avoidance of transduodenal exploration where possible and careful duodenal closure if necessary, avoidance of forceful dilation during common bile duct exploration, and a decrease in the number of negative explorations by increased use of cystic duct cholangiography

Adult↗
PubMed1975

The effect of antrectomy on gastric acid and gastrin secretion.

In three dogs with denervated fundic pouches, ingestion of beef liver test meal increased H+ output and serum gastrin levels during the first hour of the four hour experiment. H+ and serum gastrin output then slowly decreased but did not reach basal values. After antrectomy and gastroduodenal anastomosis, ingestion of the test meal did not lead to the early increase in H+ output and serum gastrin levels. Although serum gastrin levels did not significantly change throughout the four hour experiment, beginning at 80 minutes H+ output slowly increased. The rise in H+ output did not reach preantrectomy values. These results indicate that antrectomy abolishes the early rise in H+ and gastrin secretion in response to a protein test meal. Since gastrin levels did not significantly change throughout the whole experiment, the late increase in H+ output is due to a mechanism other than gastrin release.

Animals↗
PubMed1970

Relationship between pancreatic secretion and pancreatic blood flow.

An indicator fractionation technique using radioactive rubidium has been used to measure pancreatic blood flow after infusions of secretin, pancreozymin, urecholine, and pentagastrin. Secretin resulted in the production of a large volume of low viscous pancreatic juice and was associated with an increase in the cardiac output. Duodenal and pancreatic blood flow and perfusion rate were increased significantly. Blood flow to the remainder of the gastrointestinal organs was only marginally increased but the perfusion rate in each organ was increased significantly.Infusion of pancreozymin, urecholine, and pentagastrin resulted in the output of a small volume of viscous juice and was associated with no increase in cardiac output but with an increase in both pancreatic blood flow and perfusion rate.

Animals↗