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Biomedical subjects

H S Dang

Publications and source records attributed to H S Dang.

At least 19 recordsLinked to original sources
PubMed2004

Comparison of observed lung retention and urinary excretion of thorium workers and members of the public in India with the values predicted by the ICRP biokinetic model.

The daily intake of natural Th and its contents in lungs, skeleton and liver of an Indian adult population group were estimated using radiochemical neutron activation analysis (RNAA) technique. These data on daily intake (through inhalation and ingestion) were used to compute Th contents in lungs and other systemic organs such as skeleton and liver using the new human respiratory tract model (HRTM) and the new biokinetic model of Th. The theoretically computed Th contents in lungs, skeleton and liver of an average Indian adult are 2.56, 4.00 and 0.17 microg, respectively which are comparable with the corresponding experimentally measured values of 4.31, 3.45 and 0.14 microg in an urban population group living in Mumbai. The measured lung contents of Th in a group of five occupational workers were used to compute their total body Th contents and the corresponding daily urinary excretions. The computed total body contents and daily urinary excretions of Th in the five subjects compared favourably with their measured values. These studies, thus, validate the new biokinetic model of Th in natural as well as in occupational exposures in Indian conditions.

Adolescent↗
PubMed2004

Estimation of internal radiation dose to the adult Asian population from the dietary intakes of two long-lived radionuclides.

Daily dietary intakes of two naturally occurring long-lived radionuclides, 232Th and 238U, were estimated for the adult population living in a number of Asian countries, using highly sensitive analytical methods such as instrumental and radiochemical neutron activation analysis (INAA and RNAA), and inductively coupled plasma mass spectrometry (ICP-MS). The Asian countries that participated in the study were Bangladesh (BGD), China (CPR), India (IND), Japan (JPN), Pakistan (PAK), Philippines (PHI), Republic of Korea (ROK) and Vietnam (VIE). Altogether, these countries represent more than 50% of the world population. The median daily intakes of 232Th ranged between 0.6 and 14.4 mBq, the lowest being for Philippines and the highest for Bangladesh, and daily intakes of 238U ranged between 6.7 and 62.5 mBq, lowest and the highest being for India and China, respectively. The Asian median intakes were obtained as 4.2 mBq for 232Th and 12.7 mBq for 238U. Although the Asian intakes were lower than intakes of 12.3 mBq (3.0 ug) 232Th and 23.6 mBq (1.9 ug) 238U proposed by the International Commission on Radiological Protection (ICRP) for the ICRP Reference Man, they were comparable to the global intake values of 4.6 mBq 232Th and 15.6 mBq 238U proposed by the United Nation Scientific Commission on Effects of Radiation (UNSCEAR). The annual committed effective doses to Asian population from the dietary intake of 232Th and 238U were calculated to be 0.34 and 0.20 microSv, respectively, which are three orders of magnitude lower than the global average annual radiation dose of 2400 microSv to man from the natural radiation sources as proposed by UNSCEAR.

Adult↗
PubMed2004

Dietary intakes of seven elements of importance in radiological protection by asian population: comparison with ICRP data.

Within the framework of a Coordinated Research Project (CRP) organized by the International Atomic Energy Agency, Vienna, the daily dietary intakes of seven elements by adult populations living in nine Asian countries were estimated. The countries that participated in the study were Bangladesh, China, India, Indonesia, Japan, Pakistan, Philippines, South Korea (Republic of Korea, ROK), and Vietnam and together they represented more than half of the world population. The seven elements studied were calcium, cesium, iodine, potassium, strontium, thorium, and uranium. These elements have chemical and biological similarity to some of the radionuclides abundantly encountered during nuclear power production and therefore data on these elements could provide important information on their biokinetic behavior. Analyses of diet samples for these seven elements were carried out using highly sensitive and reliable analytical techniques. One thousand one hundred and sixty analytical determinations were made on two hundred and twenty samples of typical diets consumed in these countries to estimate the daily intakes of these elements by the adult Asian population. The median daily dietary intakes for the adult Asian population were found to be 0.45 g calcium, 7 microg cesium, 90 microg iodine, 1.75 g potassium, 1.65 mg strontium, 1 microg thorium, and 1 microg uranium. When compared with the intakes proposed for ICRP Reference Man by International Commission for Radiological Protection, these intakes were lower by factors of 0.41 for calcium, 0.7 for cesium, 0.45 for iodine, 0.53 for potassium, 0.87 for strontium, 0.33 for thorium, and 0.52 for uranium. The lower daily intakes of calcium, cesium, and iodine by Asian population could be due to significantly lower consumption of milk and milk products, which are rich in these elements. The significantly lower intake of calcium in most of the Asian countries may lead to higher uptake of fission nuclide 90Sr and could result in perhaps higher internal radiation dose. The use of highly sensitive and reliable analytical methods resulted in accurate and lower intake values obtained for thorium and uranium, which suggest that radiation dose from their ingestion at natural background levels is likely to be lower than what may be concluded from ICRP data.

Asia↗
PubMed2004

Contents of cesium, iodine, strontium, thorium, and uranium in selected human organs of adult asian population.

Contents of cesium, iodine, strontium, thorium, and uranium in some selected human organs were estimated for adult Asian population using data obtained in four Asian countries: China, India, Philippines, and Republic of Korea, as part of a Coordinated Research Program of the International Atomic Energy Agency on "Ingestion and Organ contents of elements of importance in radiation protection." These countries together represent more than 40% of the world population. Highly sensitive analytical techniques were employed to measure cesium in skeletal muscle, iodine in thyroid, strontium in skeleton, thorium and uranium in skeleton, liver, kidneys, and lungs where, in comparison to other organs, these elements are present in higher concentrations. The organ contents for adult Asian population, when compared with the corresponding data proposed for Reference Man by International Commission on Radiological Protection (ICRP), showed about 40 times lower kidneys content and about 10 times lower skeleton content of uranium. The content of thorium in skeleton for Asian population was also half of the ICRP Reference Man value. Interestingly, organ contents for the other elements such as iodine in thyroid, cesium in skeletal muscle, and strontium in skeleton were comparable for Asian and the Caucasian population (represented by ICRP Reference Man). Organ contents for these elements were also calculated by applying the new ICRP models of these elements to their daily intakes. The comparison of the calculated and measured organ contents showed that despite uncertainties in the organ content values arising due to the inter-country variations in daily dietary intakes, the contents were within a factor of two to three. This observation is significant since human data both on organ contents and ingestion were obtained at environmental level of intakes. The study suggests that currently available ICRP models for these elements are quite realistic.

Adult↗
PubMed2003

Validation of biokinetic models of Cs and I using their daily dietary intakes and organ contents in an adult Indian population.

The daily dietary intakes and total contents of Cs and I in skeletal muscle and thyroid, respectively, for an average Indian adult were estimated by determining their concentrations in the total cooked diet and tissue samples using instrumental neutron activation analysis. These data were then used to predict the biological half-lives of Cs and I and their radioactive counterparts for the Reference Indian Man. The predicted biological half-lives of Cs and I for Reference Indian Man were found to be comparable with the reported values for the ICRP Reference Man.

Administration, Oral↗
PubMed2000

Prevalence of chronic otitis media in a randomly selected population from two communes in southern Vietnam.

The prevalence of chronic otitis media was studied in an urban and a rural community in southern Vietnam in 1995. A total of 3,300 children, aged from 6 months to 10 years, were selected randomly by taking every third child on the vaccination list. In this cross-sectional study, 453 ears were found to have chronic otitis media or sequelae otitidis, giving an overall prevalence of 6.86%. A total of 140 ears had perforations. Various attic changes were found in 73 ears and other chronic tympanic membrane changes, such as atrophy, tympanosclerosis and adhesions, in 219 ears. Cholesteatoma was seen in two ears.

Acoustic Impedance Tests↗
PubMed1998

Point prevalence of secretory otitis media in children in southern Vietnam.

Few reliable data exist on the prevalence of secretory otitis media (SOM) in the Third World. A large epidemiologic cross-sectional study was undertaken in two communes in southern Vietnam to study an urban and a rural community during two different climatic conditions: the dry and rainy seasons. The participants included 3,300 children (6,598 ears) ages 6 months to 10 years. Otolaryngological and medical histories were obtained, and an otolaryngological examination was carried out on 1,669 children in April 1995 (the dry season) and on 1,631 children in December 1995 (the rainy season). Tympanograms were obtained (n = 6,055), 429 of which were type B curves. The overall prevalence of SOM was 7.1%, the highest incidence was at the age of 2 years (with a prevalence of 22%), and there was a significantly higher prevalence of SOM during the rainy season than during the dry season. No significant difference in incidence was found in the urban district as compared to the rural district.

Acoustic Impedance Tests↗
PubMed1995

Distribution of uranium in human organs of an urban Indian population and its relationship with clearance half-lives.

This organ burdens of uranium were estimated for an urban Indian (Bombay) population living in a normal background environment, using the technique of neutron activation analysis, in combination with post-irradiation chemical separation. The total organ burdens were: skeleton > muscle > soft tissue > lungs > kidney > liver > heart. A comparison was made between the observed organ burdens of uranium for skeleton, kidney, and muscle with those obtained by applying the metabolic model of uranium as recommended by International Commission on Radiological Protection (ICRP) to its daily intake by urban population. The observed organ burdens for kidney and muscle were found to be 4 and 70 times higher than the derived burden values; however, the two estimates were similar in the case of skeleton. This observation indicated that the clearance half-lives for uranium present in kidney and muscle tissue are likely to be longer than those reported by ICRP. For skeleton, however, the clearance half-life reported by the ICRP appeared to be reasonable.

Adult↗
PubMed1995

Studies on the biological half-lives of three important radionuclides released in nuclear power reactor operations.

The four important parameters involved in the calculation of internal radiation dose to the human body, per unit intake of a radionuclide are 1) weight and size of the body organs; 2) the biological (retention) half-life of the radionuclide; 3) radiation weighting factors for the type of radiations emanating from the radionuclide; and 4) the organ weighting factors for the organs being irradiated (target organs). Whereas, for a particular radionuclide, the radiation weighting factor and the organ weighting factors may remain constant for all humans, the other two parameters, namely, the organ weights and biological half-life, are population specific and may differ from one population group to another. For a realistic dose estimation, the population specific data on organ weights and biological half-lives for various radionuclides therefore, are needed.

Adult↗
PubMed1994

Trace element contents in food determined by neutron activation analysis and other techniques.

Advances in analytical methodology and sophisticated instrumentation introduced during the last few decades have not only helped to recognize the presence of a large number of essential and toxic trace elements in biological materials and food stuffs, but also added a new dimension in our understanding of their role in health and disease. In deficiency states, most essential trace elements cause health problems. The trace element problem as a public health issue has a very low priority in developing countries. Daily dietary intake data based on well-conducted studies are limited in many parts of the world. The present authors are in the process of generating data for the intake levels of a number of major and minor inorganic elements both in developed and developing countries. The results so far obtained show wide variations. The intake levels of several elements, including potassium, magnesium, zinc, copper, and selenium, are below the current recommended levels. The concentration of toxic metals, such as aluminum, cadmium, lead, and mercury, are within acceptable limits in most of the diets analyzed.

Adolescent↗
PubMed1993

Normal concentration and excretion ratio of uranium in serum of normal individuals in India.

This paper reports the normal concentration of uranium in the blood serum of 12 normal volunteers from the Bombay, India area who had no occupational exposure to uranium. Serum samples were analyzed by neutron activation, radiochemical separation, and gamma counting. The mean and median uranium concentrations obtained in the present study are 14 and 13 ng L-1, respectively. The median value was used to obtain the excretion ratio of 41% for uranium excreted in urine compared to that present in the blood serum pool.

Humans↗
PubMed1992

Determining the normal concentration of uranium in urine and application of the data to its biokinetics.

A method was developed to determine the concentration of uranium (238U) in urine. This method involved preconcentration of uranium from urine with calcium phosphate neutron activation followed by simple radiochemical separation. Using this method, it was possible to detect 0.2 ng of 238U. The average and geometric mean concentration of uranium found in urine of subjects from a normal background environment was 12.8 and 9.4 ng L-1, respectively. The concentration of uranium in the urine and the daily intake of uranium by the same population was used to arrive at the gastrointestinal absorption factor (f1) for uranium incorporated in the diet. The f1 factor was estimated to be 1.6%.

Adult↗