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Biomedical subjects

H S Brieler

Publications and source records attributed to H S Brieler.

15 recordsLinked to original sources
PubMed1986

[Effectiveness of various methods of stopping hemorrhage in spleen and liver injuries--results of an animal experiment study].

In 40 wistar rats liver and spleen were traumatized under standardized conditions. The hemorrhage was stopped by four different methods: 1. traditional suture technique with 4 X 0 Catgut, 2. fibrin glue, 3. endocoagulation according to Semm and 4. infrared-coagulation according to Nath.--The results show that the infrared-coagulation was the best schedule for a quick and safe bloodclotting in order to stop the hemorrhage sufficiently Concerning the postoperative lesions the infrared-coagulation had the best results also. On the other hand it could be demonstrated that this method has disadvantages with regard to the histological findings of repair mechanisms. There were deep and large areas of necrosis after infrared--as well as thermo-coagulation. The histological findings of the fibrin gluing technique, however, showed that after a few days of operation a new soft tissue grew into the traumatic lesion. Necrosis could not be identified.--If there is only short time in order to stop the hemorrhage of a parenchymatous organ we emphasize the infrared-coagulation as a favorite method because of the advantages in handling, clotting time and postoperative lesions. If there is more time in order to stop the hemorrhage we favorite the fibrin glue.

Animals↗
PubMed1979

[The effect of vasopressive drugs in managing bleedings from oesophageal varices and the intestinal tract (author's transl)].

The therapeutic effect of TGLVP a new hormonogen of vasopression in demonstrated in a pilot study: 9 patients suffering from bleeding oesophageal varices (in total 16) could be sufficiently treated by TGLVP, as well as 9 patients (in total 13) with abdominal haemorrhage of unknown aetiology and localization. Good results can be expected by TGLVP to bring gastrointestinal bleedings to a standstill.

Esophageal and Gastric Varices↗
PubMed1978

[Current aspects in the endothelialization of artificial prostheses (experimental studies in rats)].

The interaction between the blood and the inner prosthetic wall after grafting with the autoalloplastic SPARKS prostheses was examined by light and electron microscopy as well as by autoradiography. The results indicate that intercellular bridges are missing, and therefore that those cells that line the inner surface of the prosthesis are no real endothelial cells, as observed with the electron microscope. The authoradiographic findings demonstrate that blood monocytes definitely contribute to the construction of the new inner surface. We showed that although there is a possibility of transformation, the results is not a real endothelial cell, as shown by electron microscope. Nevertheless this cell apparently can fulfil its function.

Animals↗
PubMed1978

[Experimental microsurgery in rats (author's transl)].

Experimental microsurgical techniques using a magnifying glass and surgical microscope enable nearly all abdominal operations and organ transplantations to be performed in rats. Vascular and prosthetic segment implantations, portocaval anastomoses, heterotopic heart-, kidney-, spleen-, pancreas-, and liver transplantations some with superselective organangiography, are excellently demonstrated. Continuing research in microsurgery has considerably expanded experimental surgery and given new impulse to clinical surgery.

Abdomen↗
PubMed1976

[Complications of arterial reconstructions below the knee for chronic vascular occlusion (author's transl)].

From 1967 to 1976 49 reconstructions were undertaken in the area distal of the art. poplitea: 30 femoral-crural bypasses, 12 TEA und 7 orthogradic desobliterations. Complications until clinical demission were reviewed. There were in 8 cases postop. thrombosis which led to 4 amputations. 6 patients suffered from wound infection with one consecutive amputation. 4 hemmorages had to be stopped surgically. THE OVER ALL RATE OF COMPLICATIONS WAS 36,7% WITH A PRIMARY MORTALity of 4%.

Aged↗
PubMed1976

[Significance of various implantate localizations of Sparks prostheses, experimental studies in rats].

Our investigations show that Sparks prostheses after subcutaneous implantation are suitable for vascular grafting. At the end of the organization period the connective tissue becomes strong, and after the third and fourth weeks collagenous and elastic fibers can be seen. Ten weeks after s.c. implantation, collagenous fibers predominate. After this the Sparks prostheses can be used as a vascular graft. Intraperitoneal implantation, however, shows a histologically different picture with characteristic findings: only fat cells can be observed, a strong granulation tissue with elastic and collagenous fibers is not present. After intraperitoneal implantation Sparks prostheses are therefore unsuitable for vascular grafts.

Animals↗
PubMed1975

[Complications of arterial reconstructions for chronical ischemia of the lower limbs (author's transl)].

547 operations performed for reconstruction of 637 chronically occluded arterial segments in the aorto-iliac and the femoro-popliteo-crural stages were analyzed for occurred complications. Lethal event as the gravest complication happened in 4.6 p.c. of the aorto-iliac and in 1,1 p.c. of the peripheral operations. Most frequently we saw a disturbed wound healing (9.8 p.c.), but only in 0.5 p.c. a deep, also the artery including infection. Early reocclusions, caused by technical imperfectness during the performance of the operation were registered in 2.5 p.c. of the cases. In addition further observed complications are discussed.

Adult↗
PubMed1975

[Histological and histochemical evaluation of the cellular infiltration of s.c. implanted sparks prothesis. Experiments on rats (authors transl)].

Sparks-prothesis of 3 mm diameter were implanted into inbred rats and withdrawn after one to ten weeks. They were then fixed in Formalin and embedded in Paraffin and Metachrylat. After cutting (2.5 mu), the histological and histochemical parameters were examined. Cellular infiltration was studied after a certain period of time. The basic results of the genesis of that infiltration are given as follows: during the first two weeks following the s.c. implantation, derivates of monocytes (cells which play an imminent and important role during arterial replacement) were found. After the third and fourth week collagenous and elastic fibers could be seen, the connective tissue became stronger. The most favorable time for grafting can be evaluated by these experiments.

Animals↗
PubMed1975

[Local postoperative complications after surgery of the cardia].

602 patients had an operation on the cardia of stomach during 10-year period 1964-1973 in the Surgical Department of Kiel University. In total there were 395 operations without resection with a 9% postoperative complication rate opposite to 207 resections of the cardia with 38% complications. Here the primary lethality was 7% (14 patients). The complications of suture insufficiency and hemorrhage are demonstrated and their outcome checked up: 13 of 16 patients died of suture insufficiency (81%) and 8 of those 13 with hemorrhage (62%). Especially important for the successful treatment of suture insufficiency are early diagnosis, drainage of the area and closure of the leakage. A new technique of suture insufficiency treatment is reported: T-Drainage into the leakage. This has led to a lowering of the death rate.

Cardia↗