Biomedical subjects
Publications and source records attributed to H Roux.
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The authors studied the distribution of the sub-classes of T lymphocytes in the peripheral blood in 56 patients with rheumatoid arthritis (RA) by a technique of complement dependent lymphotoxicity, using monoclonal antibodies (ABm) which react with surface proteins p29/34 (HLA-DR) and Tp 30 (OKT 8-like). Classically, these ABm recognize the sub-groups of activated T cells (TA = TDR+) and cytotoxic/suppressive T cells (T c/s) respectively. In this study, normal levels of TDR+ and T c/s were found in 32% and 25% of patients respectively. However, the distribution of the values shows that 48% of the patients with rheumatoid arthritis have an increased level of TA/DR+, while 51 to 67% of patients with RA have reduced levels of T c/s, depending on which ABm was used, which suggests a heterogeneity in the T c/s sub-population. In this series, it seems that the two phenomena are preferentially associated in the small group of patients with early onset RA, while in patients with late onset RA, there is an isolated rise in the TA. These observations need to be confirmed before we can attribute an aetio-pathogenic role to the co-existence of these disorders. However, when the percentage of T c/s is greater than that of the TA, the RA has a longer clinical course than in the reverse case, which suggests the possibility of secondary immunological adaptation to the disease or an influence of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
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The authors have been treating with a synthetic D penicillamine 12 patients affected with pains in the lumbar region or lumbosciaticas imputed to duroarachnoiditis in connection with surgical procedure or/and radiculosacography. The diagnosis is based on clinical arguments (3 cases), clinical and radiological arguments (radiculosacography : 3, phlebography : 3) and on surgical arguments (3 cases). The findings are good 5 times and incomplete twice. There are 4 failures and 3 interruption of treatment out of 6 intolerances. The effect of penicillamine upon collagen could perhaps be the explanation of these results.
In a homogenous group of 31 cases of adult rheumatoid arthritis treated with gold salts and belonging to a caucasoid race in the South of France, HLA-DR groups were determined. The association with HLA-DR 4 was confirmed. DRw4 was present in 32.2 % of patients as against 12.9 % in 116 controls (p < 0.015). The relative risk of rheumatoid arthritis for DRw4 subjects is 3.3. This association is even more significant statistically in men, in spite of the small number studied (p < 0.005). The frequency of the DRw4 antigen is lower in the South than in the North of Europe (12.9 % as against 24 % respectively). The incidence of the disease and the problems of grouping for HLA-DRw4 and associated antigens are discussed.
The authors subjected 149 adult Sprague-Dawley rats to repeated experimental dives, simulated to 160 m. Histopathological examination (femurs and tibias) revealed no evidence of osteonecrosis in either normal or dyslipidaemic animals. Study of the calcium metabolism using 45Ca revealed a significant drop in the levels of free and bound calcium and in the rate of exchange between the two compartments, in the dyslipidaemic animal placed in hyperbaric conditions.
The authors report three cases of arthritis occurring after treatment with BCG immunotherapy for bladder disease. This complication is observed in 0.5 to 1% of treated patients and affects the small joints within 1 to 5 months of the first BCG injection. The clinical outcome is favourable with non-steroidal antiinflammatory drugs. This form of arthritis may be attributable to a cross-reaction between antigenic components of cartilaginous proteoglycan and BCG, influenced by a particular HLA-DR pattern, and with the intervention of a heat shock protein.
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The authors review the literautre and then proceed to analyse a series of 16 cases of Gougerot Sjögren Syndrome. The electromyogram (EMG) was abnormal on only 2 occasions. Histologically inflammatory aspects could be seen on 4 occasions with perifascicular atrophy in one case. Atrophy of II fibres was present in 7 cases together with signs of disorganization of the mitochondrial reticulum and images of mitochondrial aggregates. Under the electron microscope minor anomalies were particularly visiole and the internal structure was normal as often as not. Overall it is possible to distinguish forms of a subacute polymyositis type (4 cases), and a pauci-inflammatory myalgic type proximal to the scappular predominance (4 cases), in which the mitochondrial anomalies are commonest. Another "infraclinical" group shows no other frankly pathological changes. Finally in 3 cases the "dry" syndrome is strictly free of any muscular attack.
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