Mitomycin C may inhibit mitosis by reducing "G2" RNA synthesis.
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Animals↗
Biomedical subjects
H Rothstein
Publications and source records attributed to H Rothstein.
Duodenostomy revisited.
Four patients were admitted to the Surgical Ward because of massive bleeding from a duodenal ulcer. In three the ulcer was induced by non-steroid anti-inflammatory drugs. On operation, following pylorotomy and suture of the bleeding artery, neither drainage nor stump closure could be affected safely. Partial gastrectomy with vagotomy, or high subtotal gastrectomy with gastroenterostomy were performed. The duodenum was dealt with by means of a tube duodenostomy. There was no mortality among these patients. Morbidity was related mainly to the extent of preoperative bleeding and associated pathology (e.g. perforation). Patient data is presented in Table I.
Aged↗
[Synthesis of macromolecules in epithelial cells of the cultured amphibian lens. V. Effect of halogenated pyrimidines on mitosis and the synthesis of macromolecules].
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A comparison of pulmonary functions and oxygenation following local, spinal or general anaesthesia in patients undergoing inguinal hernia repair.
In order to compare the pulmonary effects of various anaesthetic techniques, 49 otherwise healthy patients needing inguinal hernia repair were randomized to general, spinal or local anaesthesia. Blood gases were drawn and spirometry performed pre- and postoperatively at fixed intervals. Results showed a superior ventilation and oxygenation pattern for local anaesthesia (p < 0.05). No statistically significant differences were found between the groups with respect to forced vital capacity (FVC) or forced expiratory volume per second (FEV1) but patients who had spinal anaesthesia performed worse, and for the group as a whole there was a significant reduction compared to preoperative values. We conclude that local anaesthesia is less detrimental to pulmonary function in inguinal hernia operations than spinal or general anaesthesia.
Adult↗