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Biomedical subjects

H Rose

Publications and source records attributed to H Rose.

At least 127 records · Page 7Linked to original sources
PubMed1976

[Ageing an expression of interrelation between organs and tissue of organism (author's transl)].

The authors starts from results of investigations carried out by himself, dealing with biological cell criteria of organ cultures after the donor animals had been X-rayed on their entire bodies. He discusses the problem whether ageing is an inherent character in all cells. After juvenile rats had been X-rayed, organ cultures of their milts and kidneys showed alterations analogous to those of "old" donor animals. These alterations could not be detected if the animals were killed immediately after X-raying and the cultures were taken then. The alteration of biological cell criteria are discussed as an expression of interrelations between organs and tissues of organism.

Aging↗
PubMed1974

[Application of morphological and histochemical methods for evaluation of cytostatic effects on organ cultures of malignant tumors].

Histochemical and morphological methods are reported to test the sensitivity of organ culture of human and animal tumors to cytostatics. Topochemical investigations of lactate-dehydrogenase and NADH-diaphorase in organ culture of UV-induced mice tumors have shown that there is a considerably decreased enzyme activity, as compared with the controls, after application of a clinical as well as a tenfold clinical dose, especially after treatment with trenimon and 5-fluorurazil. On the other hand a decreased activity of these enzymes was found in organ cultures of tumors induced by methylcholanthren, following application of vinblastin and 5-fluorurazil. Three out of five of the investigated mammary carcinomas exhibited a markedly decreased enzyme activity when tested with cytostatics. Furthermore, a significant decrease of the enzyme activity was observed in two ovarian carcinomas and in two malignant melanomas of three tumors examined in each case. Following the administration of cytostatics, electronmicroscopical studies showed marked changes in the mitochondria in mammary carcinomas as well as in ovarian carcinomas, whereas no alterations were found in melanomas. The findings are discussed in the light of individual chemotherapy of cancer.

Animals↗