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Biomedical subjects

H Robert

Publications and source records attributed to H Robert.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Growth disorders of the upper end of the femur following treatment of congenital hip luxation].

From approximately 2,500 cases of treated congenital dislocation of the hip, the authors have selected 82 cases with 100 hips showing disturbance of the superior epiphysis and metaphysis of the femur. These have been observed after several types of treatment - napkins in abduction, abduction harnesses, abduction splintage, closed reduction by Lorenz technique, progressive reduction by Somerville technique or open reduction. The risk factors have been analysed in 22 hips treated by progressive reduction. It is concluded that changes in the metaphysis and in the growth plate are the main cause of late abnormality. A classification of these abnormalities is proposed to aid diagnosis and for the institution of earlier treatment. In severe cases, combined pelvic and femoral osteotomy give the most satisfactory results.

Adolescent↗
PubMed1982

[Developmental ophthalmic ischemia. Regression after emergency extra-intracranial anastomosis].

Recently several publications have insisted on the ability of E.I.C.B. in reversing ocular manifestations due to chronic ophthalmic ischemia, when surgical carotid desobstruction is considered impossible or hazardous. Revascularization with E.I.C.B. can also be useful--on emergency --in case of "in evolution" ophthalmic ischemia, due to low pressure perfusion in the carotid-ophthalmic territory, to save vision. The authors report the case of a patient, presenting an optico-pyramidal syndrome "in evolution", secondary to occlusion of the left carotid artery associated with stenotic lesions in the ophthalmic artery, reversed by E.I.C.B. performed on emergency. Left visual acuity and diastolic retinian arterial pressure --respectively inferior to 1/10 and unmeasurable, before operation--raised up to 6/10 and 18 mmHg within the first twelve post-operative days and reached 8/10 and 38 mmHg after eleven weeks. This case report aims at pointing out the capacity of E.I.C.B. performed on emergency in reversing ophthalmic ischemia--"in evolution"--before constitution of irreversible lesions.

Aged↗
PubMed1978

Photoaffinity labeling of the angiotensin II receptor. 1. Synthesis and biological activities of the labeling peptides.

The synthesis and biological activities of analogues of the peptide hormone angiotensin II (AT) for use in photoaffinity labeling and receptor isolation are described. In the modified sequence of AT, Sar-Arg-Val-Tyr-Val-His-Pro-Phe, the aromatic residues Tyr and Phe have been either singly or simultaneously replaced by L-4'-nitrophenylalanine, L-4'-amino-3',5'-diiodophenylalanine, L-4'-aminophenylalanine, L-4'-diazoniumphenylalanine, and L-4'-azidophenylalanine. The peptides were assembled by solid-phase synthesis and the functional groups in position 4 and/or 8 chemically modified. Radioactivity was introduced by catalytic tritiation of the iodinated peptides to form the photolabeling precursors containing L-4'-amino-3',5'-diiodophenylalanine. On rabbit aorta the AT analogues substituted in position 4 showed poor affinities (0--15%), in position 8 high relative affinities (16--118%), and in position 4 and 8 additive effects of simultaneous substitutions. It is also shown that the new Boc derivative of L-4'-amino-3',5'-diiodophenylalanine can be used in peptide synthesis without side-chain protection.

Affinity Labels↗
PubMed1977

[Results of the surgical treatment of urinary incontinence in women. A homogenous series of 293 operations].

The statistic from 278 cases of urinary incontinence in women in a gynaecological department are reported. There was one unexpected death (from coronary thrombosis) and one hemiplegia. From the remaining cases althogether 5-7 p. 100 failures, 7-9 p. 100 partial successes and 86.5 p. 100 cures. The operations undertaken were: 33 Berkow's operation, 138 retro-public colpopexies, 29 interposition operations of placing the uterus between the bladder and the vagina, 52 sub-vesical slings of skin and 26 other different operations. All in all the percentage of failures or partial failures in the different catergories of operation are identically the same, namely about 12 p. 100. This impression can be corrected because we are dealing with small series of cases. But study of the failures in particular is indicated, to search for reasons and for whether this consistent percentage of failures may not be due to a factor which is not curable by surgery as, for instance, a factor of intrinsic muscular weakness.

Female↗
PubMed1976

[Indications and results of ileal neobladder during the development of cervix uteri cancer. Study of 32 cases].

32 uretero-ileoplasties were carried out during the course of carcinoma of the uterine cervix, where therapeutic complications required an urinary by-pass operation. A trans-ileal by-pass to the skin ensured better renal function and comfort than that provided by a skin ureterostomy. The operation carried out in 20 cases after curative radiotherapy,.remains possible with a reasonably low risk: 2 deaths. However, survival depends on the cancer. The operation is legitimate and advisable in urinary lesions due to treatment, but one wonders whether the operation is justified in cases where the carcinoma is inoperable. Present means of resuscitation made this surgery acceptable as far as the immediate risk is concerned and survival is undoubtedly comfortable. On may thus carry out again radical operations provided the lesions are limited and there is no fibropelvis after high dose cobalt-radiotherapy. But purely palliative trans-ileal urinary by-pass operations remain debatable. Their indications depend on the general condition of the patient, the desire of the surgeon to operate and the functional result of these palliative operations should not be lost by carrying out too radical an operation which will shorten survival time.

Dermatologic Surgical Procedures↗