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Biomedical subjects

H Ritter

Publications and source records attributed to H Ritter.

At least 73 records · Page 4Linked to original sources
PubMed1986

[Percutaneous transluminal dilatation (PTD) of descending stenoses of the vertebral artery].

38 stenoses of supra-aortic arteries were dilated with good success in 32 patients over a period of four years. They were 17 stenoses of the internal carotid artery, one of the common carotid artery, 16 of the subclavian artery, and four descending stenoses of the vertebral artery. Indication, method, and results of percutaneous transluminal dilatation of stenoses descending from the vertebral artery are described and discussed, with reference being made to case examples.

Angioplasty, Balloon↗
PubMed1985

The use of dietary fiber in the management of simple, childhood, idiopathic, recurrent, abdominal pain. Results in a prospective, double-blind, randomized, controlled trial.

Recurrent abdominal pain (RAP) affects 10% to 18% of school-age children and is caused by obvious organic pathology in fewer than 10% of cases. Two recent studies do not support previous beliefs that most RAP is psychogenic. Studies have shown disorders of bowel motility in children with RAP similar to those of adult irritable bowel syndrome (IBS); controlled trials of additional dietary fiber in adult IBS have shown beneficial results. We did a randomized, double-blind, placebo-controlled study in 52 children with RAP and demonstrated a clinically and statistically significant decrease in pain attacks (at least 50% fewer) in almost twice as many children who were given additional fiber as placebo. Compliance was excellent in both groups and side effects were few. Although the cause of RAP is poorly understood, it is hypothesized that the beneficial effect of added fiber is due to its effect on shortening transit time, as in IBS.

Abdomen↗
PubMed1985

Linkage between the loci for mitochondrial malic enzyme (ME2) and coagulation factor XIIIA subunit (F13A).

The locus for the mitochondrial malic enzyme (ME2) seems to be closely linked to the gene coding for the A subunit of coagulation factor XIII (F13A). From 18 informative families with 54 children a maximum lod score of 4.33 was obtained at a recombination fraction of 0.10. Since the assignment of F13A to the short arm of chromosome 6 was recently confirmed, the locus for ME2 can be added to this linkage group. The map order seems to be: GLO1 - HLA - F13A - ME2.

Adult↗
PubMed1984

Cell fusion responsible for horizontal oncogenesis by human tumors in nude mice.

Human tumor xenotransplants derived from 4 different carcinomas were established in athymic mice and maintained by serial passage. In vivo human/mouse cell fusion and induction of neoplastic growth of adjacent mouse tissue was investigated in serial passages by isoenzyme analysis, by chromosome analysis and by cloning of induced tumorigenic mouse cells. In 2 xenotransplants human/murine hybrid isoenzyme complexes of pyruvate-glutamate transaminase, glucosephosphate isomerase and mitochondrial malate dehydrogenase were detected. Metaphases containing human and murine chromosomes were found in the first in vitro passage of excised xenotransplants. Cloning of induced mouse tumor cells yielded tumor cell lines tumorigenic in athymic as well as in immunocompetent mice.

Animals↗
PubMed1984

Antenatal records: do they help us? A new record for watching fetal growth.

An antenatal record is described which uses a questionnaire to detect mothers and babies at risk, and a graph for charting fetal growth indirectly, by maternal weight, height of fundus, and girth, to give a clear picture. By working out scores for fetal growth and cervical ripeness, guidance is given on when to take action to save babies likely to be born too soon or too late. Our slogan, "Be a Fetal Growth Watcher", serves as a mnemonic for: "Fundus, Girth, Weight".

Botswana↗
PubMed1984

[Value of radiological diagnosis in the complex study of femur head necrosis in children. 2. Scintigraphic and arteriographic studies in the framework of the complex diagnosis of femur head necrosis].

101 scintigraphic investigations and 42 angiograms show that the vascular tamponade is the decisive factor for the beginning of necrosis of the femoral head ossification center. Plain films, scintigraphy and angiography give information of the duration of the disease. Extent and localisation of the circulatory disturbance are important for the prognosis of the disease. From stage classification and prognostic factors the conclusions for therapy can be drawn.

Adolescent↗
PubMed1983

[Diagnosis of thrombosis with indium-111 labeled thrombocytes].

The distribution pattern of 111In-labelled autologous platelets was investigated in 50 patients. Imaging was performed with a scintillation camera connected to a computer system. 20 patients suffering from obliterative arterial disease showed a normal platelet distribution. Endothelial lesions after arteriography were found in 6 out of 10 patients. 15 of 20 patients with suspected venous thrombosis showed local platelet deposition. 10 of these patients with local platelet depositions were investigated by phlebography. Positive findings (fresh thrombi) were found in 8 patients. Optimum results were obtained by injecting platelets distal to the venous thrombus. Signs of thrombosis are interruption of blood flow, collateral formation and platelet deposition. This new method offers possibilities of radioisotopic diagnosis of parietal thrombus and venous thrombosis despite anticoagulation or fibrinolysis.

Adolescent↗
PubMed1983

[133Xe-labeling of tissue adhesives for catheter embolization].

A method for radio-nuclide labelling of histo-acryl/lipiodol with 133Xe gas is described. The method consists of dissolving the gas in lipiodol under sterile conditions. After embolization and angiography, the localisation of the embolizing material can be determined by means of a scintillation camera. The labelling method was used in 15 patients. In all patients the position of the embolizing material, as demonstrated by scintigraphy, corresponded with the radiological findings. It was not possible to demonstrate escape of the material by scintigraphy.

Embolization, Therapeutic↗
PubMed1983

[Venography with 111Indium-labelled autologous thrombocytes].

111Indium-labelled thrombocytes were used for radionuclide venography in ten patients. All types of thrombi could be demonstrated with a high degree of accuracy, particularly if the marked thrombocytes were injected distally. In cases of complete occlusion by thrombus, the peripheral end of the clot appeared as a 'hot spot'. Non-occluding thrombi with a thrombogenic surface can be differentiated from lesions of the endothelium. Compared with venography using labelled microspheres, labelled thrombocytes have the advantage of demonstrating the degree of activity of the thrombotic process.

Blood Platelets↗
PubMed1983

[Percutaneous transluminal angioplasty of the subclavian artery].

In 1981, percutaneous transluminal angioplasty (PTA) of the subclavian artery was performed in 10 patients. 8 stenotic lesions were localized in the first segment and two in the third segment respectively. Dilatation was performed with the Grüntzig balloon-catheter ranging from 4 to 7 French. PTA was successful in 9 of the 10 cases. Success of dilatation was documented by recording blood pressure, normalization in the pre- and poststenotic segment and by clinical results. Success of PTA depends on exact angiographic studies, adequate indication and subsequent anticoagulation treatment. Early results after PTA are excellent. PTA of stenotic subclavian arteries has proved an alternative to surgical management.

Angioplasty, Balloon↗
PubMed1983

[Diagnosis and therapy of cerebellar angioblastomas].

The mainly infratentorially occurring angioblastomas belong to the group of benign vascular tumours. Histologically, however, one can distinguish from them pleomorphically undifferentiated forms which have an unfavourable prognosis. The article reports on a group of 20 patients who were operated on in the period from 1978 to 1982. The frequency among the brain tumours seen in the same period of time was 4.5 per cent, only related to the infratentorial tumours. Symptomatically, the signs of occlusive hydrocephalus were well to the fore. The exactness of the topical diagnosis by computer tomography in conjunction with microsurgical operation techniques enables a reduction of the operation risk. The postoperative lethality rate was 3 among 20 patients. Attention was drawn to the observation of a family with a genuine v. Hippel-Lindau syndrome in an incomplete form in a descending line with probably autosomal, dominant heredity.

Adult↗
PubMed1982

In vitro studies on the interaction between bile salts and key enzymes of the liver.

Interactions between bile salts and cellular constituents are of considerable significance in studies on cholestasis. The main points of interest are the effects of the various bile salts on lipid and protein structures. Of primary interest are the interactions with lipids since these can cause disorder in cellular metabolism by eliminating compartmentalization. Conformational changes of proteins can occur through interactions with bile salts. They can involve specific functions. Of special importance here are the enzymes, since these are decisive supportive agents in cellular processes. In this paper, the effect of various bile salts on the activity of key hepatic enzymes was studied. In addition to the kinetic tests for enzyme activity, structural changes of the enzymes were studied as well using electrophoretic techniques. It could be shown that even much lower bile salt concentrations than those which occur in bile can lead to a complete inhibition of activity. The varying sensitivities of different enzymes when they react in the presence of bile salts is striking. According to the degree of hydroxylation, the various bile salts show characteristic differences in inhibitory effect on enzymatic activity. On the basis of the results reported here, it is quite possible that the interaction between bile salts and enzymes is a participating factor in the etiology and pathogenesis of cholestatic hepatic changes.

Alanine Transaminase↗