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Biomedical subjects

H Richards

Publications and source records attributed to H Richards.

At least 55 records · Page 3Linked to original sources
PubMed1988

The changing nature of population education for workers.

The efforts of the International Labour Office (ILO) to educate workers in developing countries about population issues and family planning are discussed. "The author traces the evolution of ILO thinking from population control to family planning to family and community welfare and discusses the rationale for concentrating on the industrial sector, the programmes' orientation, content and methods, and the need to involve personnel managers and trade union leaders in particular."

Demography↗
PubMed1987

Hearing loss due to mumps.

The possibility of mumps was considered in 33 children with profound unilateral sensorineural hearing loss of unknown origin. Fifteen gave a history of mumps, of whom 12 contracted the infection between the last normal and first abnormal hearing tests. Hearing should be tested after mumps infection.

Child↗
PubMed1986

Bifonazole 1% gel in the treatment of superficial dermatophytoses and erythrasma of the feet and groin.

An open, non-comparative study was carried out by four general practitioners into the efficacy and tolerability of a new antifungal preparation, bifonazole 1% gel. The preparation was used once daily to treat clinically diagnosed, superficial dermatophytoses and erythrasma of the feet or groin in 91 patients of which 51 were confirmed by mycological examination. A complete mycological evaluation was available for 28 patients and a cure was recorded in 23 (89%) of these cases. Four patients reported discomfort and burning on application of the preparation and changed to alternative treatments.

Adolescent↗
PubMed1983

Cloning and expression of a porcine prorelaxin gene in E. coli.

A porcine prorelaxin gene has been constructed partly by synthetic means and partly from its natural messenger RNA. A gene coding for the 32 N-terminal amino acids including a chain initiator methionine codon (B gene) was synthesised and inserted in a plasmid at a site downstream from a tryptophan promoter in such a way that its expression is under the control of the trp promoter. DNA corresponding to the rest of the prorelaxin was prepared using reverse transcriptase extension of a primer complementary to relaxin mRNA and joined at a suitable restriction site to the B gene. Transformation of E. coli with this plasmid followed by suitable induction resulted in the synthesis of a new protein identified as prorelaxin by its size and its antigenic similarity to relaxin.

Amino Acid Sequence↗
PubMed1981

Salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole.

Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient.

Adult↗
PubMed1981

Diversity of plasmids responsible for multiple resistance in Klebsiella serotype K2.

Klebsiella of capsular type K2 were investigated to find out whether a single epidemic clone was the source of many outbreaks of infection in different hospitals, in different areas over a period of five years. The klebsiellas studied were found to be very similar; they were of the same biotype, had similar klebecin sensitivity patterns and carried multiple drug-resistance plasmids; however, characterization of these plasmids showed that they were heterogeneous. Thus there was not a single epidemic bacterial clone.

Cross Infection↗
PubMed1980

Distribution of genes for trimethoprim and gentamicin resistance in bacteria and their plasmids in a general hospital.

The incidence of trimethoprim resistance in enterobacteria causing infection in a London hospital increased from 5.6% in 1970 to 16% in 1979. The proportion of gentamicin-resistant aerobic Gram-negative bacilli had risen to 6.5% by 1979. During a 5-month period in 1977, during which no epidemic was recognized, all isolates resistant to either trimethoprim, gentamicin, tobramycin or amikacin were studied. The proportion of enterobacteria resistant to both trimethoprim and gentamicin (3.8% of the total) was significantly higher than expected assuming no correlation between acquisition of resistance characters. The resistance was transferable in 23% of trimethoprim-resistant and 76% of gentamicin-resistant strains. Trimethoprim resistance was carried by plasmids of seven different incompatibility groups and in at least four instances was part of a transposon. Gentamicin resistance was determined by plasmids of three groups - IncC, IncFII and IncW. Transposition of gentamicin resistance was not shown, though this may have been the means of evolution of the gentamicin R plasmids of InW, which determined aminoglycoside acetyltransferase, AAC(3). Some bacterial strains with their plasmids were endemic. There was evidence for these plasmids (i) acquiring new resistance genes by transposition, (ii) losing resistance genes by deletion and (iii) being transferred between bacterial species in the hospital.

Amikacin↗
PubMed1978

Copy numbers of coexisting plasmids in Escherichia coli K-12.

A strain of Escherichia coli K-12 carrying eight compatible and distinguishable plasmids was constructed. The amounts of plasmid DNA (measured as supercoiled molecules) per chromosome in this strain was about equal to the sum of the plasmid DNAs, extracted under controlled conditions, from strains each carrying one of the eight plasmids. Analysis of these DNA preparations showed that each plasmid in the multiplasmid strain was present in the same proportion per chromosome as in the single-plasmid strains. Also the level of phenotypic expression of each plasmid in the multiplasmid strain was the same as in the single-plasmid strains. Each plasmid, therefore, appears to control its own copy number irrespective of the presence of other compatible plasmids.

Conjugation, Genetic↗
PubMed1978

Tactile-perceptual functioning and academic performance in brain-impaired and unimpaired children.

The purpose of this study was to determine whether tactile perception is a useful predictor of academic performance. 50 control and 42 brain-impaired (epileptic) children were examined. Both groups showed a strong relationship between tactile perceptual integrity and academic achievement. Analyses of extreme groups indicated that academic performance is clearly ordered by tactile perceptual skill not only for children with documented brain impairment but also for a normal control group as well. The implications for additions to the traditional cognitively oriented psychological test battery were discussed.

Achievement↗
PubMed1976

Factors in the adherence of flexor tendon after repair: an experimental study in the rabbit.

The effects of splintage, suture and excision of the tendon sheath on the healing of incompletely transected flexor tendons in the rabbit have been evaluated separately and in various combinations. When all procedures were done together, repair was accompanied by dense adhesion formation with little evidence of any healing activity by the tendon cells. The experiments indicated that the adhesions were the result not of any one single factor studied but of all three contributing in varying degrees. Suturing produced the most adhesions but synovial sheath excision and immobilisation also contributed. It is suggested that these factors are also responsible for the adhesions which occur after flexor tendon repair in clinical practice.

Animals↗