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Biomedical subjects

H Renck

Publications and source records attributed to H Renck.

51 records · Page 3Linked to original sources
PubMed1976

Thoracic epidural analgesia-II: prolongation in the early postoperative period by continuous injection of 1.0% bupivacaine.

Sixteen patients were given thoracic epidural analgesia at the T5-T6 level with 2 ml of 1.0% bupivacaine solution plain for pain relief after upper abdominal surgery. In 13 cases the analgesia was prolonged by continuous injection of 1.0% bupivacaine for 24 or 48 h. Onset time and segmental spread of the analgesia are presented as well as segmental spread, intensity of the blockade, and peak expiratory flow rates during prolongation. Signs of tachyphylaxis were noticed, and also signs of accumulation of bupivacaine in plasma. A high incidence of urinary retention occurred. The method is not considered to be ideal for pain relief after upper abdominal surgery.

Adolescent↗
PubMed1976

Thoracic epidural analgesia III--prolongation in the early postoperative period by intermittent injections of etidocaine with adrenaline.

In 38 patients who had undergone elective upper abdominal surgery, postoperative analgesia was obtained by thoracic epidual analgesia, prolonged by intermittent injections of 3.0, 4.0 and 5.0 ml, respectively, of 1.0% etidocaine with adrenaline 1:200,000. The spread of analgesia after repeated doses is given, as are also the incidences of incomplete analgesia and urinary retention. Signs of tachyphylaxis were noticed. Decreases in the systolic blood pressure were evident, especially after the first injections in the three groups investigated. The falls in blood pressure in the 5 ml group were so pronounced that this part of the study had to be terminated. Accumulation of etidocaine in plasma was noticed in all groups. The clinical implications of the method are discussed.

Acetanilides↗
PubMed1975

Thoracic epidural analgesia I-a double-blind study between bupivacaine and etidocaine.

A double-blind comparison was made in 40 patients undergoing thoracic epidural analgesia with either bupivacaine 0.5% or etidocaine 1.0%, both with adrenaline 5 mug/ml. All patients were undergoing elective upper abdominal surgery. They were studied both pre- and postoperatively. The parameters measured were: onset time, segmental spread and duration of analgesia; and also systolic blood pressure, heart rate and peak expiratory flow rate. In respect of these parameters, no major differences were found between the two solutions under the conditions of the study. The overall results, however, differ in many respects to those found when these agents are used in lumbar epidural analgesia.

Acetanilides↗
PubMed1975

Thoracic epidural analgesia -- a double blind study between etidocaine and bupivacaine.

In a double-blind study on 40 patients for elective upper abdominal surgery, measurements was made of onset time, duration and segmental spread of analgesia, systolic blood pressure, heart rate and peak expiratory flow during thoracic epidural analgesia with etidocaine 1% and bupivacaine 0.5%, both containing adrenaline 5 mug/ml. No major differences were found between the two agents. The results differ in many aspects from those obtained with these agents in lumbar epidural analgesia.

Acetanilides↗
PubMedDate not supplied

Antinociceptive effects of localized administration of opioids compared with lidocaine.

To study possible antinociceptive effects of perineurally administered opioids, the rat infraorbital nerve block (IONB) model was employed for investigations of opioids (morphine, meperidine, buprenorphine, ethylketocyclazocine, and fentanyl) of differing receptor selectivity and physicochemical properties such as lipid solubility. Only meperidine in doses greater than 1 mg/kg produced localized analgesia, the duration of which increased dose-dependently. Naloxone failed to counteract the analgesic effects of meperidine. It is concluded that meperidine exerted its effect by a local anesthetic action and not by the activation of opioid receptors in the peripheral nerve. The local anesthetic potency of meperidine was compared with that of lidocaine in peripheral nerve blocks (IONB in rats and sciatic nerve block in guinea pigs), in central nerve blocks (epidural anesthesia in guinea pigs and spinal anesthesia in mice), and in infiltration anesthesia in guinea pigs. Time to onset of block was generally longer for meperidine. Equal amounts of the drugs produced motor blocks of similar durations except in epidural anesthesia where meperidine was clearly shorter. Sensory blocks were longer with meperidine than with lidocaine when applied in equal amounts to the infraorbital nerve and subarachnoidally. The two agents caused a similar duration of sensory block in infiltration anesthesia. Meperidine was shorter than lidocaine in epidural anesthesia. The characteristics of blocks induced by the two agents may be explained by structural differences and associated differences in physicochemical properties such as lipid solubility and pKa.

Analgesia, Epidural↗