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Biomedical subjects

H Ren

Publications and source records attributed to H Ren.

At least 181 records · Page 10Linked to original sources
PubMed1991

Esophageal diverticulum associated with carcinoma of the esophagus--a report of four cases.

During a 25-year period, four patients with esophageal diverticulum associated with carcinoma of the esophagus underwent surgery. The results were satisfactory. The clinical features included a long history of diverticulum and the presence of a carcinoma of the esophagus in close proximity to the former. Inflammation within the diverticulum and in the mucosa around the diverticulum was noted. The closer the diverticulum to the carcinoma, the more severe the inflammation. Therefore, diverticulitis and esophagitis may be important factors leading to the development of carcinoma of the esophagus, and patients with esophageal diverticulum should be followed up regularly and the diverticulum resected as early as possible if inflammation within the diverticulum or peri-diverticular esophagitis is found.

Diverticulum, Esophageal↗
PubMed1991

[The report of 2 cases of thyroid cancer with intratracheal growth].

From 1961-1987, 28 patients were operated upon for tracheal tumor, including 2 cases of thyroid cancer with intratracheal growth. Operative findings showed that in these cases a small intraluminal cancer mass and large extraluminal cancer mass were fixed together. Intratracheal growth was secondary to extratracheal thyroid cancer. Evidence of cancer from aberrant intratracheal thyroid tissues was not found. Differential diagnosis of tracheal tumor from thyroid cancer with intratracheal growth is difficult. Palliative resection with post-operative irradiation was used in these two cases because of the generally poor condition of the patients.

Adenocarcinoma↗
PubMed1991

[A study of protein engineering for human cardionatrin. II. Construction of two new human cardionatrin analog genes, RH-2 & RH-3 by intragenic recombination in vitro].

Two new analog genes of the alpha-human atrial natriuretic polypeptide (alpha-hANP) were constructed by accurate intragenic recombination of analog RH-1 gene with ANP gene in vitro, both of which had been synthesized and reported. One recombined analog gene, RH-2, was designed to contain an equivalent of the alpha-hANP gene, capping the peptidase inhibitor SQ20881 sequence at its 5'end. The other analog gene, RH-3, was designed to contain an equivalent of the alpha-hANP gene, wedging in two proline codons CCG & CCG at the 3' end. The recombinants bearing the genes, bacteriophage RH-2/M13mp18 & RH-3/M13mp18, were identified by DNA domain combination analysis--in situ hybridization and dot blotting with three probes matching three specific DNA domains, and by restriction analysis. The DNA sequences of RH-2 and RH-3 were confirmed by the dideoxynucleotide chain termination method.

Amino Acid Sequence↗
PubMed1991

[Esophageal diverticulum].

During a 25-year period, nineteen patients with esophageal diverticulum were treated surgically in PUMC Hospital. Of them, eleven cases underwent resection of the diverticulum (10 pulsion type and 1 traction type); and four cases were treated by inversion suturing of the diverticulum (all traction type). The results of follow-up showed that pulsion diverticulum resection was satisfactory, and the resection was better than inversion suturing for traction-type diverticula. In this series, diverticulitis and esophagitis were present in all cases. Carcinoma of the esophagus developed at site near the diverticulum in 4 cases. Pathologic examination demonstrated severe submucosal inflammatory infiltration and epithelial hyperplasia of the esophagus associated with the diverticulum, with these changes being increasingly severe with the precondition of the carcinoma to the diverticulum. Carcinoma of the esophagus as a complication of diverticulum may be associated with chronic diverticulitis and esophagitis.

Adult↗
PubMed1991

Pleural plaques do not predict asbestosis: high-resolution computed tomography and pathology study.

Pleural plaques can be caused by asbestos exposure, but their predictive value in diagnosing pulmonary asbestosis is uncertain. Similarly, although high-resolution computed tomography (HRCT) can accurately detect parenchymal lung lesions, its ability to detect asbestosis is unknown. In a test of the predictive value of pleural plaques and HRCT, lungs of 29 autopsied patients with bilateral parietal pleural plaques were compared with lungs from 29 age- and sex-matched controls without pleural plaques. Significantly more of the patients with pleural plaques had histories of asbestos exposure (P less than 0.01). One lung from each patient was inflation fixed and air dried. HRCT of the lungs did not show significantly more thickening, lines, or densities in patients with pleural plaques than did controls; and HRCT did not predict a significantly greater likelihood of asbestos-related parenchymal disease in the study group. Gross and histologic examinations showed no significant intergroup differences in the frequency or severity of several forms of emphysema and fibrosis. Average asbestos fiber counts were not significantly higher in the lungs with pleural plaques. We conclude that pleural plaques do not predict asbestosis, and that high-resolution computed tomography accurately detects interstitial and parenchymal lung disease but cannot reliably diagnose asbestosis.

Adult↗
PubMed1990

Three-dimensional CT-volumetric reconstruction and display of the bronchial tree.

We applied a refined version of our volumetric rendering technique for three-dimensional (3-D) computed tomographic (CT) imaging to display the cadaveric lung and the major components of the bronchial tree. We report details of the technical aspects of 3-D imaging of the lung, and four representative case studies of lung specimens from our initial experience.

Bronchography↗
PubMed1990

Amiodarone pulmonary toxicity: CT findings in symptomatic patients.

The computed tomographic (CT) chest scans of 11 patients who developed respiratory or constitutional symptoms while receiving amiodarone therapy were reviewed. CT findings indicative of significant amiodarone exposure included (a) high-attenuation parenchymal-pleural lesions in eight of the 11 patients (73%), and (b) increased liver and/or spleen attenuation in 10 of the 11 patients (91%). Nonspecific pulmonary infiltrates were identified in nine of the 11 patients (82%). Four patients had interstitial infiltrates, four had mixed alveolar and interstitial disease, and one had a conglomerate mass. CT findings of high-attenuation parenchymal-pleural abnormalities are thought to be related to the iodinated chemistry of the drug and its prolonged half-life within the lung. These unique properties of the drug and the use of CT to discriminate attenuation levels provide a means of identifying patients with significant pulmonary accumulation of amiodarone.

Adult↗
PubMed1990

Accelerated arteriosclerosis in heart transplant recipients is associated with a T-lymphocyte-mediated endothelialitis.

Accelerated arteriosclerosis has emerged as a major life-threatening complication in long-term survivors of heart transplantation. It has been proposed that accelerated arteriosclerosis is an immune-mediated complication of rejection. We observed a striking endothelialitis in the coronary arteries of two explanted hearts obtained from patients with severe transplant-related accelerated arteriosclerosis. This finding prompted us to review the pathologic changes in the coronary arteries of 23 autopsied patients who had received heart transplants. The infiltrate in these vessels was characterized using immunohistochemical stains for lymphocytes (CD45), macrophages (MAC-387), T lymphocytes (CD45RO), B lymphocytes (L-26), and smooth muscle cells (actin). In addition, a full panel of monoclonal antibodies was used on the fresh-frozen tissue available from one of the two explanted hearts. Ten of the eleven recipients with accelerated arteriosclerosis had a moderate to marked lymphocytic endothelialitis compared to 3 of 14 without transplant-related arteriosclerosis (P less than 0.005). Immunohistochemical staining of the paraffin-embedded material demonstrated that most of the lymphocytes in the subendothelial space of these vessels were T lymphocytes and that this infiltrate was associated with an accumulation of macrophages and a proliferation of smooth muscle cells in the intima. In the explanted heart from which fresh-frozen tissue was available for more detailed cell typing, the T cells marked predominantly as cytotoxic T lymphocytes (CD8+, CD2+). These results suggest that accelerated arteriosclerosis may be mediated, in part, by a cytotoxic T-lymphocyte-directed endothelialitis.

Adult↗
PubMed1990

[A study of protein engineering for human cardionatrin. I. Synthesis, cloning and expression of a gene analog of human atrial natriuretic polypeptide in E. coli].

An analog of the alpha-human atrial natriuretic polypeptide (alpha-hANP) gene, articulated with a peptidase inhibitor SQ20881 at its N-terminal and two prolines at the C-terminal was expressed in E. coli by cloning the reconstituted plasmid pRHL-1 in vivo. This gene analog, RH-1, comprising 154 base pairs in total, was designed to contain an equivalent of the alpha-hANP gene, capping the peptidase inhibitor SQ20881 at its 5' end with a glutamic acid codon GAA to facilitate enzymatic cleavage of the expressed end product by endoproteinase Glu-C, wedging in two proline codons CCG & CCG before the double terminal codons TGA TAG at the 3' end to retard hydrolysis of the expressed product by exopeptidase, and adding 3 restriction sites to both ends. Synthesis of the RH-1 gene was effected enzymatically by joining in predicted order the ten segments of oligodeoxynucleotides which had been chemically synthesized by the solid-phase phosphite-triester method. The synthetic gene was cloned into vector M13mp18. Phage bearing the gene analog was identified by dot blotting and restriction endonuclease mapping. Nucleotide sequence of the gene was determined by the dideoxynucleotide chain termination method.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acid Sequence↗
PubMed1990

Anesthetic management for the excision of pheochromocytoma.

Anesthetic experiences involving 23 patients with pheochromocytoma during the period 1983-1986 are reported. Typical clinical symptoms and positive laboratory results were found in all patients. Epidural block was used in 11, general anesthesia in 10, and a combination of the two in 2 cases. Swan-Ganz catheter was used to monitor hemodynamic changes during anesthesia and surgery. Before excision of the tumor, a larger volume of fluid was transfused than was lost, resulting in the elevation and/or maintenance of pulmonary arterial pressure (PAP) and pulmonary capillary wedge pressure (PCWP) at the upper limit of the normal range. Once venous supply was secured, the incidence of critical hypotension following resection of the tumor was reduced significantly. But it was difficult to avoid this blood pressure drop in some cases, and intravenous infusion of catecholamines was required. After tumor excision a marked decline of myocardial function was observed. This suggests that myocardial dysfunction might be another important factor of severe hypotension, along with the total peripheral resistance (TPR) decrease and relative hypovolemia. Blood pressures of patients undergoing epidural block were stable or slightly decreased during the establishment of anesthesia. However, in all cases of general anesthesia a variable hypotension was observed during induction and intubation. We therefore recommend epidural block for abdominal pheochromocytoma resection in order to avoid the marked fluctuation of blood pressure which may accompany the induction of general anesthesia.

Adolescent↗
PubMed1990

Hemorrhagic infarction of hilar lymph nodes associated with combined heart-lung transplantation.

The histologic changes in lymph nodes transplanted during combined heart-lung transplantation were examined. We studied at autopsy nine patients who had received a total of 10 heart-lung transplants. Hemorrhagic infarction of hilar nodes was found in eight of the 10 transplanted lungs. Pulmonary parenchymal pathologic changes associated with lymph node infarction included acute rejection (two cases), chronic rejection with bronchiolitis obliterans (two cases), and pneumonia (four cases). In one of the transplants without lymph node infarction there was chronic rejection with bronchiolitis obliterans and in another there was evidence of bronchopneumonia. The hemorrhagic lymph node infarction seen in the recipients of combined heart-lung transplant's may be directly attributable to the interruption of bronchial arteries and veins by the surgical procedure. At present the possible contribution of node infarction to postoperative morbidity or mortality is unknown.

Adolescent↗
PubMed1989

Fulminant pulmonary calcification complicating renal transplantation: CT demonstration.

The authors report a case of fulminant, metastatic lung calcification leading to progressive respiratory failure in a patient who underwent unsuccessful renal transplantation. Premortem computed tomographic (CT) examination of the lung demonstrated the presence of high-attenuation (greater than 100 HU) parenchymal consolidation, compatible with metastatic calcium deposition. By depicting significant pulmonary calcification not seen on conventional radiographs, CT facilitated identification of an important contributing factor to the patient's respiratory failure and death.

Adult↗
PubMed1989

[Treatment of 100 patients with small cell lung cancer].

100 patients with small cell lung cancer were treated in Peking Union Medical College Hospital from 1963 through 1987. The five year survival rate in patients received combined treatment (resection + chemotherapy+radiotherapy, resection+chemotherapy or resection+radiotherapy,) was 18.52% (5/27). It was better than patients received nonsurgical treatment (chemotherapy,radiotherapy or chemotherapy+radiotherapy, 58 patients). And also it was better than patients received surgical resection only (11 patients). This advantage was especially marked in patients with lesion of IIIa stage. The five year survival rate in this group was 26.31%(5/19). It was suggested that combined method (resection+chemotherapy+radiotherapy) is the first choice for the treatment of small cell lung cancer.

Adult↗
PubMed1989

[B-cell differential factor (IL-6) in peripheral mononuclear cells in viral hepatitis B infections].

B-cell differential factor (BCDF) activities were determined in 58 patients with various types of hepatitis B. In comparison with normal subjects, BCDF activities were significantly increased in patients with FH and CAH (P less than 0.01), markedly decreased in HBsAg carriers (P less than 0.01) and presented no change in patients with CPH and AH. It is interesting that there was a significant positive correlation between BCDF activity and serum titer of anti-HBC or serum globulin levels. No correlation was observed between BCDF activity and serum anti-HBs levels. It is suggested that abnormal BCDF activity might attribute to aberration of immunoregulation of HBV infections.

Adult↗
PubMed1988

Studies on fermented corn flour food poisoning in rural areas of China. II. Isolation and identification of causal microorganisms.

Using potato dextrose agar medium, 40 strains of microorganisms were isolated from leftover fermented corn flour samples involved in outbreaks of food poisoning. All strains produced powerful toxins which caused the same intoxication to mice, dogs, and monkeys as the leftover food samples. On the basis of results obtained from the morphology of this bacteria and its colony, from biochemical tests, and from the G-C mole percentage in DNA, the bacteria was identified as Flavobacterium farinofermentans nov. sp. (Meng, Z. and Wang, D.).

Agglutination Tests↗
PubMed1988

Studies on fermented corn flour poisoning in rural areas of China. I. Epidemiology, Clinical Manifestations, and Pathology.

An outbreak of a new type of fatal food poisoning has been reported in different parts of the People's Republic of China. Liver, kidney, heart, and brain were the main target organs, and the overall fatality of intoxicated individuals was 38.2%. Evidence obtained from epidemiological studies and animal tests indicates that the food poisoning was caused by the consumption of homemade fermented corn flour products.

Animals↗