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Biomedical subjects

H Regis

Publications and source records attributed to H Regis.

At least 19 recordsLinked to original sources
PubMed1998

Immunoradiometric assay of thyroglobulin in patients with differentiated thyroid carcinomas: need for thyroglobulin recovery tests.

As interference from thyroglobulin autoantibodies appears to have been overcome in new commercial thyroglobulin assays by the use of monoclonal antibodies, the need for thyroglobulin recovery tests became uncertain. Sera (n=45) from patients with differentiated thyroid carcinomas were selected on the basis of a thyroglobulin recovery value below 70% in the Dynotest Tg immunoradiometric assay (Brahms) routinely used in our laboratory. Serum thyroglobulin levels were then measured using three other commercial immunoradiometric assays: thyroglobulin ERIA (Pasteur), HTGK (Sorin) and ELSA HTG (Cis Bio International). Thyroglobulin autoantibodies were measured using the Thyrak assay (Brahms). Although many patients were thyroglobulin antibodies-negative (< 200 U/ml, n=26), most immunoradiometric assays failed to detect thyroglobulin in patients with evidence of recurrence. Low thyroglobulin values associated with low thyroglobulin recovery in thyroglobulin antibody-negative patients appear to be more biologically relevant than a single low thyroglobulin value, which can lead to lack of medical intervention. We conclude that the thyroglobulin recovery test is a prerequisite for the correct interpretation of serum thyroglobulin levels determined with immunoradiometric assays in the follow-up of thyroglobulin autoantibody-negative patients treated for differentiated thyroid carcinomas.

Cell Differentiation↗
PubMed1993

Effect of drug transit time between exchange locus with plasma and sampling site.

In pharmacokinetic models used to describe the behavior of drugs in living organisms, generally neither the amount of drug flowing in pipes between compartments nor the transfer delay between the plasma-lymph exchange areas and a site of measurement are taken into account. Several former publications dealt with exchanges between two or more different organs assuming that the blood flow was constant or that the variation of the lymphatic flow was negligible or noting that the amount of drug present in pipes was not easily taken into account. In this article, we deal with concentration in a site of interstitial exchanges with regard to concentration in a sampling site with a varying blood flow, assuming that the transit time depends both on the fluid flow and the path length through pipes. In all considered cases, the plasma concentration profile may be highly altered by a change in the flow rate.

Humans↗
PubMed1992

Sleep electroencephalogram at the early stage of Creutzfeldt-Jakob disease.

We describe sleep EEG studies in three patients at the early stage of Creutzfeldt-Jakob disease. Little work has been devoted to the study of the sleep EEG in the course of the CJ disease: disorganized sleep architecture was noted, associated with a decrease in stage 4 and an almost complete disappearance of the REM stage. Our patients were considered to have normal stage 2; yet spindles and K complexes were rare at this stage. No evolution towards stage 4 was noted. The percentage of rapid eye movement sleep was significantly low in two cases and normal in one case. Sleep disturbances in the other dementing disorders are reported.

Aged↗
PubMed1990

Sensory evoked potentials in Creutzfeldt-Jakob disease.

Eight patients presenting with intermediate or terminal evolution of Creutzfeldt-Jakob disease (CJD) were investigated by means of evoked potentials. Fifteen age-matched healthy subjects served as controls. The 8 patients had well-recognizable but simplified flash evoked potentials (FEPs) consisting of P1 and N2 waves followed by a single late positive (P2) deflection. Enlarged FEPs were found in 2 of the 8 patients. The somatosensory central conduction time was normal in 3 of 5 patients, and it resulted in upper normal limits or was moderately slowed in 2 patients. No enlarged somatosensory scalp potentials were recorded. Cortical somatosensory responses were characterized by an unrecognizable (4 patients) or delayed (2 patients) N33 wave. Brainstem auditory evoked responses, recorded in 6 patients, were normal. In CJD very important functional impairment of the sensory cortical areas is associated with absent or mild dysfunction of the subcortical sensory pathways.

Acoustic Stimulation↗
PubMed1990

[Detection of respiratory allergies using the Phadiatop test in children 1 to 6 years of age].

Phadiatop, a new test for detecting hypersensitivity to airborne allergens, was used in 83 children aged 9 months to 6 years with recurrent respiratory manifestations, i.e. recurrent expiratory obstruction and/or recurrent respiratory infections. A good correlation was found between this test and both the prick tests (95%) and the specific IgE assays (91% for RASTS of classes greater than or equal to 1, and 95% for RASTS of classes greater than or equal to 2). However, the correlation was less strong with the total IgE level (68%). The overall correlation with the specialist's prediction based on history and physical evaluation was excellent (94%). In this study, Phadiatop was found to have a 90% sensitivity and a 98% specificity. Furthermore, this test costs 40% less than the often used strategy combining skin tests and determinations of total and specific IgE levels. In the age group studied, Phadiatop is most useful above the age of two, since in younger patients true respiratory allergies are fairly infrequent in recurrent ENT and lower respiratory tract infections, whereas infections are far more common.

Child↗
PubMed1988

[Multimodal evoked potentials in partial epilepsy in children].

A multimodal evoked potential study was realised in three groups of children or adolescents 5 to 15 years old. The first group included 25 normal non-epileptic subjects; the second group was composed of 27 subjects with partial idiopathic epilepsy (PIE) (benign childhood epilepsy with centro-temporal spike; childhood epilepsy with occipital paroxysms); the third group was formed of 20 subjects with partial symptomatic epilepsy (PSE) without patent anatomical lesion or with anatomical lesion. Recording for each subject included: flash visual evoked potentials, pattern visual evoked potentials, brainstem auditory evoked potentials and somatosensory evoked potentials. Each curve obtained was studied for the response morphology, the measure of the different wave latencies, the inter-peak latencies (conduction time) and the amplitudes. A statistical treatment of the data was performed to evaluate the significance of variation of the different parameter values obtained for the various groups. Among the significantly modified parameters, we found: an increase of the amplitudes in the PIE and a decrease in the PSE, specially when an anatomical lesion exists; an asymmetrical amplitude of the somatosensory responses in the PIE with centro-temporal spike; an increase of the central somatosensory conduction time in the PSE with anatomical lesion.

Adolescent↗
PubMed1985

[Somatosensory evoked potentials and action myoclonus].

The authors studied the somatosensory evoked potentials (SEPs) in 16 cases of myoclonic encephalopathies: 8 cases of dyssynergia cerebellaris myoclonica (DCM); 2 cases of dyssynergia cerebellaris progressiva (DCP); 2 cases of Lafora's disease; 1 case of ceroid lipofuscinosis; 3 unclassifiable myoclonic syndromes. The mean age of the patients was 18 years and the mean duration of pre-study evolution was 10 years. All the patients had been treated by anticonvulsant drugs (phenobarbital, valproic acid, benzodiazepines). The amplitude of the complex P1N2 at the level of the contralateral parietal cortex, with stimulation of the median nerve at the wrist, was found to be enlarged in only 6 cases and giant responses (over 40 microV) were obtained in 2 cases. Only half of the patients with DCM presented a high amplitude response. There was no correlation either with clinical parameters (and in particular, certain patients with marked action myoclonic jerks have a normal SEP), or with the EEG data: on the contrary, the amplitude variations of the SEPs are most often similar to variations of the visual evoked potentials.

Adolescent↗
PubMed1980

Lipomas of the corpus callosum and epilepsy.

An analysis of four cases of lipomas of the corpus callosum with epilepsy, and a review of the literature, have led to the following conclusions: (1) Epilepsy as an almost constant feature is often severe, nearly always partial, and begins before the age of 15. (2) Pathophysiology of the seizures appears to be essentially an interhemispheric disconnection (rather than the classic theory that seizures depend upon an infiltration of the cingulate gyri by fibrous tissue growing out from the capsule of the lipoma). This disconnection is responsible for a facilitatory and disinhibitory action that favors the appearance of seizures caused by an epileptogenic lesion (the effects of which remain subthreshold in the presence of an intact corpus callosum playing its normal inhibitory role). This hypothesis is clearly applicable in explaining the epilepsies--in every way comparable--that are observed in agenesis of the corpus callosum and in Marchiafava-Bignami disease.

Adolescent↗
PubMed1977

[The brain in the aged].

Under the very broad term of brain in the elderly, we cannot consider exhaustively all the anatomical, physiopathological and pathological aspect and, still less, the therapeutic possibilities in diseases of the anesthetist should know concerning the special characteristics of this aging organ. First are recalled the anatomical, macro and microscopic data of the senile brain. The metabolic characteristics are then considered. Investigations which may give the clinician information concerning the organic state and metabolic capacities of the brain of the elderly subject, e.g. cerebral blood flow, fundus oculi, E.E.G. brain arteriography, tacography or tomodensitometry by scanner, are consideres. But in practice, they are difficult to use and their data are only relatively reliable, i.e. clinical examination is of great imporatnce and the overall impression prevails. The therapeutic possibilities are limited and in these elderly subjects with cerebral metabolism in unstable equilibrium, one should be circumspect and careful in treatment.

Aged↗
PubMed1976

[Effect of ablation of the motor cortex or the cerebellum on postural-kinetic coordination in the cat].

1. A cat, restrained in a hammock, stands with its feet on supporting trays each furnished with strain gauges to measure the isometric upthrust. Placing reactions are elicited by contact of the left or right forelimb with a moving tray. The placing movement is preceded and accompanied by a postural adjustment characterized by an increase of the upthrust exerted by the opposite forelimb. 2. After ablation of the motor cortex on one side, the placing movement of the contralateral forelimb is abolished for the first few days after the operation and thereafter is delayed. However, the postural adjustment of the ipsilateral forelimb persists, with the same range of latencies as before the operation. 3. After unilateral motor cortical ablation, the contralateral forelimb still takes part in the postural adjustment associated with the placing movement of the other forelimb. 4. In two cats which had 2 years earlier undergone a total cerebellectomy, the placing movement was lacking or appeared with a long delay, whereas a postural adjustment of the other forelimb could be observed, although reduced. 5. The results indicate that the nervous structures responsible for the movement and for the associated postural adjustment are separate but partially linked.

Animals↗
PubMed1975

[Influence of inaccuracy of certain parameters on dose distribution in telecobalt therapy (author's transl)].

Progress in dosimetry and in radiobiology together with the evolution of radiation generators led to adopt very elaborated radiotherapy protocols. However, the therapist should have confidence in these protocols on condition that irradiation parameters are strictly respected. For obvious reasons, this is impossible despite the meticulous rules. In this, paper, we therefore intend to study the role of the angle of incidence on the actual distribution of doses; we also study the inaccuracy of certain parameters recorded during preparation for the therapy or shown during successive irradiation courses. In this paper we retain only errors which can be easily quantified. These are errors concerning the irradiation apparatus (source to skin distance, angle of the rays, field dimension) and those due to factors related to the patient treated: contour measurement, entrance point of rays and positional changes of the patient. The different errors can be associated in various ways for a given therapy protocol. For the same reason, an isodose of a given nominal value will have several curves. All these tracings are lined by two curves which we call "superior and inferior envelops": these border the "incertitude area". It can be said that at the end of the treatment, the given isodose lies in this area; it is however impossible to define its form or exact position. A few examples in the text illustrate these results and show the possible practical angles of incidence. If we assume that errors during successive irradiations are distributed at random, a certain compensation is noted and the "areas of incertitude" decrease. But if the errors are constantly on the same side, as is sometimes the case, the dose distribution can be very different from that predicted in the dosimetric protocol.

Breast Neoplasms↗