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Biomedical subjects

H R Wilson

Publications and source records attributed to H R Wilson.

At least 199 records · Page 11Linked to original sources
PubMed1972

Excitatory and inhibitory interactions in localized populations of model neurons.

Coupled nonlinear differential equations are derived for the dynamics of spatially localized populations containing both excitatory and inhibitory model neurons. Phase plane methods and numerical solutions are then used to investigate population responses to various types of stimuli. The results obtained show simple and multiple hysteresis phenomena and limit cycle activity. The latter is particularly interesting since the frequency of the limit cycle oscillation is found to be a monotonic function of stimulus intensity. Finally, it is proved that the existence of limit cycle dynamics in response to one class of stimuli implies the existence of multiple stable states and hysteresis in response to a different class of stimuli. The relation between these findings and a number of experiments is discussed.

Evoked Potentials↗
PubMed1971

Immunosuppressive agents in intracellular infection: besnoitiosis in hamsters.

When tested for their activity in suppressing the acquisition of immunity during acute Besnoitia infection of hamsters, antilymphocyte serum (ALS), aminopterin, cyclophosphamide, cortisol, and whole-body irradiation were the most active agents and effectively blocked the development of immunity during 4 to 12 days of immunization. Actinomycin D and chlorambucil were moderately active, and nitrogen mustard, 6-mercaptopurine, and vinblastine exhibited slight immunosuppressive activity. Established immunity was especially labile to cortisol and cortisone administration with generalized Besnoitia relapse occurring consistently in all hamsters; this occurred infrequently during cyclophosphamide treatment. Focal relapse was seen in chronically irradiated and ALS-treated hamsters, but the location of the lesions differed. Irradiated hamsters had lesions in the lungs and brain, whereas ALS-treated hamsters showed splenic relapse. Acquisition of immunity was more sensitive to suppression than established immunity and did not necessarily parallel antibody development and vice versa, emphasizing the importance of cellular over humoral factors in immunity to this intracellular parasite.

Journal Article↗