Cataract: how much surgery do we have to do?
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Aged↗
Biomedical subjects
H R Taylor
Publications and source records attributed to H R Taylor.
Epidemiology of pterygium in Victoria, Australia.
AIM: To describe the prevalence of and risk factors for pterygium in a population based sample of residents of the Australian state of Victoria who were aged 40 years and older. METHODS: The strata comprised nine randomly selected clusters from the Melbourne statistical division, 14 nursing homes randomly selected from the nursing homes within a 5 kilometre radius of the nine Melbourne clusters, and four randomly selected clusters from rural Victoria. Pterygium was measured in millimetres from the tip to the middle of the base. During an interview, people were queried about previous ocular surgery, including surgical removal of pterygium, and their lifetime exposure to sunlight. RESULTS: 5147 people participated. They ranged in age from 40 to 101 years and 2850 (55.4%) were female. Only one person in the Melbourne cohort reported previous pterygium surgery, and seven rural residents reported previous surgery; this information was unavailable for the nursing home residents. Pterygium was present upon clinical examination in 39 (1.2%) of the 3229 Melbourne residents who had the clinical examination, six (1. 7%) of the nursing home residents, and 96 (6.7%) of the rural residents. The overall weighted population rate in the population was 2.83% (95% CL 2.35, 3.31). The independent risk factors for pterygium were found to be age (OR=1.23, 95% CL=1.06, 1.44), male sex (OR=2.02, 95% CL=1.35, 3.03), rural residence (OR=5.28, 95% CL=3. 56, 7.84), and lifetime ocular sun exposure (OR=1.63, 95% CL=1.18, 2. 25). The attributable risk of sunlight and pterygium was 43.6% (95% CL=42.7, 44.6). The result was the same when ocular UV-B exposure was substituted in the model for broad band sun exposure. CONCLUSION: Pterygium is a significant public health problem in rural areas, primarily as a result of ocular sun exposure.
Adult↗
Fluoroquinolone and fortified antibiotics for treating bacterial corneal ulcers.
AIM: To compare the clinical efficacy of commercially available fluoroquinolone drops with the use of combined fortified antibiotics (tobramycin 1.3%-cefazolin 5%) in treatment of bacterial corneal ulcer. METHODS: The medical records of 140 patients with a diagnosis of bacterial corneal ulcer who were admitted to the Royal Victorian Eye and Ear Hospital, Melbourne, Australia between January 1993 and December 1997 were reviewed retrospectively. Final outcome and results of 138 ulcer episodes were compared between those treated initially with fluoroquinolone and those who received fortified antibiotics. Two patients had been treated with chloramphenicol. RESULTS: No significant treatment difference was found between fluoroquinolone and fortified therapy in terms of final visual outcome. However, serious complications such as corneal perforation, evisceration, or enucleation of the affected eye were more common with fluoroquinolone therapy (16.7%) compared with the fortified therapy (2.4%, p= 0.02). The duration of intensive therapy was less with fluoroquinolone especially in those over 60 years of age (4 days v 6 days, p=0.01). Hospital stay was also less in the fluoroquinolone group compared with the fortified group for all patients and was significantly less with fluoroquinolone treatment (7 days v 10 days, p=0.02) in patients in the age group over 60 years old. CONCLUSIONS: Monotherapy with fluoroquinolone eye drops for the treatment of bacterial corneal ulcers led to shorter duration of intensive therapy and shorter hospital stay compared with combined fortified therapy (tobramycin-cefazolin). This finding may have resulted from quicker clinical response of healing as a result of less toxicity found in the patients treated with fluoroquinolone. However, as some serious complications were encountered more commonly in the fluoroquinolone group, caution should be exercised in using fluoroquinolones in large, deep ulcers in the elderly.
Adult↗
Diabetic retinopathy in Victoria, Australia: the Visual Impairment Project.
AIM: To establish the prevalence, severity, and risk factors for diabetic retinopathy in a representative sample of Victorian residents aged 40 years and older. METHODS: A population based, cluster sampling method was used to recruit 4744 participants (86% participation rate). Nine randomly selected, suburban Melbourne clusters and four randomly selected, rural Victorian clusters were used. Participants provided a detailed medical and personal history and underwent an ocular examination including funduscopy and fundus photography. Rural participants provided a blood sample, from which the glycosylated haemoglobin percentage was measured. The diagnosis of diabetic retinopathy was based on fundus photographs from participants with self reported diabetes. RESULTS: The prevalence of diabetic retinopathy among people with self reported diabetes was 29. 1%. The prevalence of untreated, vision threatening retinopathy was 2.8%. Retinopathy was positively associated with a longer reported duration of diabetes diagnosis (p<0.01) and with higher fractions of glycosylated haemoglobin (p<0.01). Retinopathy was not significantly associated with age, ethnicity, body mass index, glaucoma, myopia or intake of alcohol, tobacco, or aspirin (all p > 0.05). CONCLUSIONS: Most people in Victoria with proliferative diabetic retinopathy or clinically significant macular oedema have received laser treatment. There remains however, a small but important group who have not received treatment and whose vision is threatened. People with diabetes should be encouraged to maintain strict glycaemic control and to undergo regular screening to delay or prevent the development of retinopathy.
Adult↗
Recruitment methods for community-based screening for diabetic retinopathy.
Regular screening of all people with diabetes is the most efficient and cost-effective way to detect early stages of diabetic retinopathy so that laser treatment can be performed at the optimal time. A major aim of the Program for the Early Detection of Diabetic Retinopathy was to increase compliance with guidelines for screening for diabetic retinopathy. This community-based screening program used non-mydriatic retinal photography and was initiated in four areas of Victoria, Australia from 1996-1998. Recruitment strategies included targeted mail-outs, provision of the program brochure in English and the main languages spoken in the areas and media promotion in ethnic newspapers and on ethnic radio stations. In Victoria, only 55% of the population with diabetes currently access eye care services at the recommended intervals. This program was able to increase compliance with guidelines to 70% among people with diabetes that had not had a recent eye examination. A total of 1,197 people with diabetes were screened for diabetic retinopathy. Of the 1,197 people who were screened, 620 (15% of the estimated number of people with diabetes) had not had their eyes examined in the past two years. This pilot study identified strategies to encourage people with diabetes to have their eyes examined at the recommended intervals.
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Attributable risk estimates for cataract to prioritize medical and public health action.
PURPOSE: Cataract is the most common cause of blindness in the world. The purpose of this study was to estimate the population attributable risk associated with identified risk factors for cortical, nuclear, and posterior subcapsular (PSC) cataract in a representative sample of the Victorian population aged 40 years and older. METHODS: Cluster, stratified sampling was used and participants were recruited through a household census. At locally established test sites, standardized clinical examinations were performed to assess cataract and personal interviews were conducted to quantify potential risk factors. Multivariate logistic regression was used to determine the independent risk factors associated with the three types of cataract, and the population attributable risk was calculated. RESULTS: A total of 3271 (83% of eligible) of the urban residents and 1473 (92%) rural residents participated. The urban residents ranged in age from 40 to 98 years (mean, 59 years), and 1511 (46%) were men. The rural residents ranged in age from 40 to 103 years (mean, 60 years), and 701 (48%) were men. The overall prevalence of cortical cataract was 12.1% (95% CL 10.5, 13.8), nuclear cataract 12.6% (95% CL 9.61, 15.7), and PSC cataract 4.93% (95% CL 3.68, 6.17). Significant risk factors for cortical cataract included age, female gender, diabetes for greater than 5 years, gout for greater than 20 years, arthritis, myopia, average annual ocular UV-B exposure, and family history of cataract (parents or siblings). Significant risk factors for nuclear cataract included age, female gender, rural residence, age-related maculopathy, diabetes for greater than 5 years, smoker for greater than 30 years, and myopia. The significant risk factors for PSC cataract were age, rural residence, thiazide diuretic use, and myopia. Of the modifiable risk factors, ocular UV-B exposure explains 10% of the cortical cataract in the community, and cigarette smoking accounts for 17% of the nuclear cataract. CONCLUSIONS: Because of the near universal exposure to UV-B in the environment, ocular protection has one of the highest modifiable attributable risks for cortical cataract and would therefore be an ideal target for public health intervention. Quit smoking campaigns can be expanded to incorporate information about the excess cataract in the community associated with long-term smoking. Nonmodifiable risk factors such as age, gender, and long-term medication use have implications for the timely referral and treatment for those at higher risk of cataract.
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Vision impairment predicts five-year mortality.
PURPOSE: To describe predictors of mortality in the 5-year follow-up of the Melbourne Visual Impairment Project (VIP) cohort. METHODS: The Melbourne VIP was a population-based study of the distribution and determinants of age-related eye disease in a cluster random sample of Melbourne residents aged 40 years and older. Baseline examinations were conducted between 1992 and 1994. In 1997, 5-year follow-up examinations of the original cohort commenced. Causes of death were obtained from the National Death Index for all reported deaths. RESULTS: Of the original 3,271 participants, 231 (7.1%) were reported to have died in the intervening 5 years. Of the remaining 3,040 participants eligible to return for follow-up examinations, 2,594 (85% of eligible) did participate, 51 (2%) had moved interstate or overseas, 83 (3%) could not be traced, and 312 (10%) refused to participate. Best corrected visual acuity < 6/12 and cortical cataract were associated with a significantly increased risk of mortality, as were increasing age, male sex, increased duration of cigarette smoking, increased duration of hypertension, and arthritis. CONCLUSIONS: Even mild visual impairment increases the risk of death more than twofold.
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Prevalence of amblyopia and associated refractive errors in an adult population in Victoria, Australia.
The study aimed to describe the prevalence of amblyopia and associated refractive errors among an adult Australian population. The Visual Impairment Project (VIP) is a population-based study of age-related eye disease in the state of Victoria, Australia. Data were collected through standardised interviews and orthoptic and ophthalmic dilated examinations. Amblyopia was defined as best-corrected visual acuity of 6/9 or worse in the absence of any pathological cause. The participants were 3,265 urban residents and 1,456 rural residents of the VIP ranging in age from 40-92 years (mean = 59 years; 53% female). The prevalence of unilateral amblyopia was 3.06% (95% C.I. 2.59, 3.53). Amblyopia was not found to be statistically different by age group (p=0.096), gender (p=0.675), or place of birth (p=0.14). Anisometropia was statistically more common (p<0.001) in amblyopic cases (51.1%) compared to the normal population (9.7%), and 54% of amblyopic eyes had visual acuity of worse than 6/12. Amblyopia is a significant cause of unilateral reduced visual acuity in a population aged 40 years and older. Anisometropia was more prevalent and the degree of anisometropia was greater in the amblyopic group compared with the normal population. Oblique astigmatism was more prevalent in the amblyopic group compared with the normal population.
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Self-reported diabetes and distribution of HbA1c in a population-based sample in Victoria.
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Adult↗
Prevalence and risk factors of myopia in Victoria, Australia.
OBJECTIVE: To determine the prevalence and risk factors of myopia in urban and rural Victoria, Australia. PARTICIPANTS AND METHODS: The Visual Impairment Project is a population-based prevalence study of eye disease in which both urban and rural adult populations were examined. Refractive data on the participants were collected using logMAR visual acuity, corrective lens measurement, and subjective refraction. All refractive error data were converted into spherical equivalent and myopia was defined at 2 levels: worse than -0.5 diopters (D) and worse than -1.00 D. RESULTS: A total of 3271 (83%) urban and 1473 (91%) rural residents were examined. The overall prevalence of myopia worse than -0.50 D in the population was 17% (95% confidence limit = 15.8%, 18.0%). Prevalence of myopia decreased from 24% in those aged 40 to 49 years to 12% in those aged 70 to 79 years, and then increased to 17% in people older than 80 years. The younger age groups also had higher usage of myopic corrective lenses throughout their lives than the older age groups, indicating an increased use of myopic corrective lenses in recent times. Myopia was found to be significantly higher in people with higher education levels (chi2 = 119.20, P < .001), in clerks and professionals (chi2 = 132.53, P < .001), in people born in southeast Asia (chi2 = 77.62, P < .001), and in people with higher degrees of nuclear opacity (chi2 = 55.26, P < .001). CONCLUSION: Myopia rates in the Visual Impairment Project generally decrease with age and use of myopic correction has increased in recent times. Myopia was significantly related to education level, occupation, country of birth, and nuclear opacity.
Adult↗
Prevalence and predictors of undercorrected refractive errors in the Victorian population.
PURPOSE: To investigate the prevalence and predictors of undercorrected refractive errors in the Victorian population. METHODS: In this prospective study, a population-based sample of residents was recruited. The improvement in visual acuity with subjective refraction was assessed. Several individual characteristics were investigated as predictors of undercorrected refractive error. RESULTS: There were 5,615 eligible residents, of which 4,735 (84%) participated in the study (53% were women). In all, 466 participants (10%) had significant undercorrected refractive error leading to an improvement of 1 or more lines of visual acuity with refraction. Age was the most important predisposing factor. The risk of undercorrected refractive error increased by 1.8 times for every decade of life starting at 40 years of age. The next most important factor was the absence of distance refractive correction. These individuals were 6.8 times more at risk compared with those who wore distance spectacles. Other significant predictors of undercorrected refractive error were the presence of cataract and European or Middle Eastern languages spoken at home. People with tertiary education or hypermetropia were less likely to need refractive error improvement. Gender, country of birth, and employment status did not have any statistically significant effect after controlling for confounders. CONCLUSIONS: The results of this study disclose people in the community who are more at risk of compromising their vision because of undercorrected refractive errors. A campaign is warranted to alert people that it may be possible to improve their vision.
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The epidemiology of cataract in Australia.
PURPOSE: To describe the prevalence and risk factors for cataract in an Australian population aged 40 years and older. METHODS: Participants were recruited by a household census and stratified, random cluster sampling to represent residents of Victoria, Australia, aged 40 years and older. The following information was collected: initial visual acuity and best-corrected visual acuity, demographic details, health history, dietary intake of antioxidants, lifetime ocular ultraviolet B exposure, and clinical eye examination, including lens photography. Cortical opacities were measured in sixteenths. Cortical cataract was defined as opacity greater than or equal to 4/16 of pupil circumference. Nuclear opacities were graded according to the Wilmer cataract grading scheme, and cataract was defined as greater than or equal to nuclear standard 2.0 of four standards. The height and width of any posterior subcapsular opacity was measured and recorded. Posterior subcapsular cataract was defined as posterior subcapsular opacity greater than or equal to 1 mm2. The worse eye was selected for analysis. Backward stepwise logistic regression was used to quantify independent risk factors for cataract. RESULTS: A total of 3,271 (83% of eligible) of the urban residents, 403 (90% of eligible) nursing home residents, and 1,473 (92% of eligible) rural residents participated. The urban residents ranged in age from 40 to 98 years (mean, 59 years), and 1,511 (46%) were men. The nursing home residents ranged in age from 46 to 101 years (mean, 82 years), and 85 (21%) were men. The rural residents ranged in age from 40 to 103 years (mean, 60 years), and 701 (47.5%) were men. The overall weighted rate of cortical cataract was 11.3% (95% confidence limits, 9.68%, 13.0%) excluding cataract surgery and 12.1% (95% confidence limits, 10.5%, 13.8%) including cataract surgery. The risk factors for cortical cataract that remained in the multivariate logistic regression model were age, female gender, diabetes duration greater than 5 years, gout duration greater than 10 years, arthritis diagnosis, myopia, use of oral beta-blockers, and increased average annual ocular ultraviolet B exposure. Overall, 12.6% (95% confidence limits, 9.61%, 15.7%) of Victorians aged 40 years and older had nuclear cataract including previous cataract surgery, and 11.6% (95% confidence limits, 8.61%, 14.7%) had nuclear cataract excluding previous cataract surgery. In the urban and rural cohorts, age, female gender, rural residence, brown irides, diabetes diagnosed 5 or more years earlier, myopia, age-related maculopathy, having smoked for greater than 30 years, and an interaction between ocular ultraviolet B exposure and vitamin E were all risk factors for nuclear cataract. The rate of posterior subcapsular cataract excluding previous cataract surgery was 4.08% (95% confidence limits, 3.01%, 5.14%), whereas the overall rate of posterior subcapsular cataract including previous cataract surgery was 4.93% (95% confidence limits, 3.68%, 6.17%) . The independent risk factors for posterior subcapsular cataract in the urban and rural cohorts that remained were age in years, rural location, use of thiazide diuretics, vitamin E intake, and myopia. CONCLUSIONS: The expected increase in the prevalence of cataract with the aging of the population highlights the need to plan appropriate medical services and public health interventions for primary and secondary prevention. Many of the identified risk factors for cataract in the population have the potential for being modified through public health interventions.
Adult↗
Schizophrenia, psychotropic medication, and cataract.
OBJECTIVE: To compare the distribution of cataract types between psychiatric patients diagnosed with schizophrenia and the general population not exposed to psychotropic medication, and to compare cataract prevalence between users and nonusers of various psychotropic medications in the general community. DESIGN: Case-control. PARTICIPANTS: A total of 151 (93%) eligible patients from a community mental health service and 3271 (83%) eligible residents from the Melbourne Visual Impairment Project (VIP) were examined. MAIN OUTCOME MEASURES: All patients 40 years of age and older from a community mental health service and residents of nine randomly selected areas of Melbourne were eligible. Best-corrected distance visual acuity was determined using a 4-m logarithm of the minimum angle of resolution (LogMAR) chart. The presence of cataract was determined by photographs or slit-lamp examination using direct and indirect retroillumination. Anterior, cortical, nuclear, and posterior subcapsular cataracts were measured. Participants from the Melbourne VIP were classified as to whether they had taken benzodiazepams, phenothiazines, thioxanthenes, butyrophenols, tricyclic antidepressants, or monoamine oxidase inhibitors for at least 12 months during their lifetime. RESULTS: The distribution of cataract type varied between persons with and without schizophrenia. Anterior subcapsular (ASC) cataract was significantly more prevalent (26%) in participants with schizophrenia from the community mental health service than Melbourne VIP participants (0.2%) not exposed to psychotropic medication (chi-square, 1 degree of freedom = 605.5, P = 0.001). This remained significant after controlling for age (odds ratios = 250, 95% confidence interval = 83.3, 1000). The distribution of the age-related cataract was similar across all groups of psychotropic medication users with the exception of the phenothiazine users. They had less of all types of the age-related cataracts, despite being slightly older than the control group (mean age, 60.0 vs. 58.4, t test = 0.85, P = 0.40). However, only cortical cataract in the phenothiazine group was statistically lower (chi-square, 1 degree of freedom = 3.96, P = 0.047). CONCLUSION: This study has identified the need to investigate whether other newer agents, especially high-potency medications, cause ASC opacities if a certain threshold of exposure to psychotropic medications must be attained to develop cataract, or if schizophrenia itself is associated with cataract formation.
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Epidemiology of ocular trauma in Australia.
PURPOSE: To describe the prevalence and risk factors of ocular trauma in a representative sample of Australians aged 40 and over who reside in the state of Victoria. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Australians aged 40 years and older living in Victoria. METHODS: Cluster, stratified sampling was used to identify permanent residents for a population-based study of eye disease. A standardized examination that included visual acuity and information about ocular trauma was conducted. MAIN OUTCOME MEASURES: Self-reported history of ocular trauma and circumstances surrounding the events. RESULTS: A total of 3271 (83% of eligible) Melbourne residents and 1473 (92% of eligible) rural residents were examined. The overall rate of eye injury history in Victoria was 21.1% (95% confidence limits [CL] 19.6%, 22.5%). Men were far more likely than women to have ever experienced an eye injury (34.2% versus 9.9%), and rural men were more likely than Melbourne men to have ever had an eye injury (42.1 % versus 30.5%). The workplace accounted for the majority of eye injuries (60%), followed by the home (24%). The location with the highest percent of people reporting the use of eye protection at the time of the injury was the workplace (18.5%); the workplace accounted for the lowest rate of hospitalization (4.9%). The industry with highest cumulative rate of eye injuries was communication (14 per 1000), whereas the highest occupation-specific cumulative rates of eye injury were recorded for tradespersons (18 per 1000). CONCLUSIONS: Although ocular trauma is usually not associated with bilateral vision impairment, it is a major public health problem in Australia. Rural men, people engaged in hammering or sport, and those in the trades are at highest risk and require specific, targeted, prevention messages.
Accidents, Occupational↗
Epidemiology of age-related cataract.
To investigate the aetiology of cataract, it is necessary to measure both the type and severity of lens opacities, as well as the dose and duration of exposure to the putative risk factor. Great advances have been made in recent years in our ability to measure cataract and some putative risk factors. Our current understanding of the aetiology of cataract shows that by far the greatest effect is seen with increasing 'age'. However, exposure to ultraviolet-B (UV-B) radiation, use of dietary antioxidant vitamins and the presence of diabetes, the occurrence of dehydration and severe diarrhoea and the use of therapeutic drugs such as steroids, and recreational drugs such as nicotine and alcohol, may be important risk factors. Until the results of the current studies of the effectiveness of antioxidant vitamin supplements become available, the only effective protective interventions to reduce the risk of cataract seem to be to reduce ocular exposure to UV-B radiation and to stop smoking.
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A comparison of the career aspirations of degree and P2000 diploma graduates from UK nursing programmes.
AIM: This paper reports the findings from a study of career aspirations undertaken as part of a larger study on the graduate outcomes of two different preregistration nursing educational programmes in the UK. METHODS: A self-completion questionnaire was administered to 52 degree graduates and 28 diplomates from two Universities on completion of their course. FINDINGS: The findings suggest that while graduates appeared more definite over their long-term career goals, diplomates were more confident in their initial decision to enter the nursing profession. All respondents showed a marked tendency towards hospital-based clinical posts on graduation. Degree graduates displayed a greater interest in working overseas, nominating a far broader range of possible destinations and expressed interest in a wider range of further education courses, including Master's and PhD degrees. CONCLUSIONS: The career aspirations of degree graduates and diplomates revealed in this study highlight a number of issues with implications for workforce planning, recruitment and retainment. Further larger scale longitudinal research is warranted.
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Baseline ophthalmic findings in the vitamin E, cataract and age-related maculopathy (VECAT) study.
PURPOSE: To describe the methodology of eye examination and the baseline eye characteristics of the Vitamin E, Cataract and Age-Related Maculopathy (VECAT) study participants. METHODS: A sample of volunteers from an urban area of Melbourne, Australia, were recruited to participate in a randomized, controlled trial investigating the effect of vitamin E on the development of cataract and age-related maculopathy Standardized eye examinations involved clinical assessment, which included Wilmer grading of the lens, digital photography of the lens with Nidek EAS-1000 lens camera and stereo photography of the macular area with the Nidek 3-DX fundus camera. All cases of ophthalmic findings were determined on the basis of pathology in the worse eye. RESULTS: Most eyes were free from abnormalities. The most frequent findings were cataract and age-related macular changes. Nuclear cataract (nuclear opacity grade >2) was present in 4.5%, cortical cataract (cortical opacity grade >2) in 14.3% and posterior subcapsular cataract in 3.0% of participants; in addition, coronary cataract was observed in 13.6%. Soft drusen larger than 125 pm were found in 11.4%, retinal pigment epithelium changes in 9.5%, epiretinal membrane in 6.6% and age-related macular degeneration in 0.5% of participants. SUMMARY: Due to the selection criteria, the majority of participants had clear or minor lens changes and/or minor retinal age-related changes. Precise instrumental documentation will allow an accurate assessment of the incidence and dynamics of these changes throughout 4 years of observation.
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The role of past intake of vitamin E in early cataract changes.
PURPOSE: We examined the association between prior supplementation of vitamin E and early cataract changes in volunteers currently enrolled in the cross-sectional VECAT study. The Vitamin E and Cataract Prevention Study (VECAT) is a clinical trial currently in progress, designed to assess the affect of vitamin E supplementation on the development and progression of cataract and age-related macular degeneration. METHODS: A history of vitamin E supplementation was ascertained through a self-administered questionnaire that was mailed to each of the 1,111 participants who were enrolled at the time in the prospective VECAT Study. RESULTS: With a 99% response rate, we found that 26% of participants reported prior supplementation of vitamin E. Only 8.8% of these participants took supplementation greater than the recommended daily intake (RDI) of 10 mg/day. Of these 26%, 57% took supplementation in the form of multivitamins as opposed to a vitamin E supplement on its own. The range of supplement intake ranged from as little as 0.1 mg/day to a maximum of 55 mg/day. A statistically significant association was found between prior supplementation and the absence of cortical opacity (OR = 0.47, 95%CI = 0.28-0.83), after adjusting for age. The levels of nuclear opacity (NO) were not statistically different between those who reported intake and those with no prior vitamin E supplementation. CONCLUSION: Prior vitamin E supplementation may protect VECAT participants from developing at least early cortical cataracts. No apparent protective role in terms of nuclear opacities and nuclear color was found regardless of the level, regularity or duration of intake.
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