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Biomedical subjects

H R Pillsbury

Publications and source records attributed to H R Pillsbury.

9 recordsLinked to original sources
PubMed1979

Clinical vs histopathologic staging in laryngeal cancer.

One hundred fourteen serially sectioned, nonirradiated, laryngeal specimens that were removed for cancer have been examined to determine the accuracy of preoperative staging. Characteristics of the primary lesion, which indicate invasion of the laryngeal framework, have been demonstrated for each region in the larynx. Pathologic findings, such as submucosal extension, growth into the preepiglottic space, infraglottic extension, and involvement of the laryngeal ventricle, have been correlated with clinical staging. The relationship between tumor size and accuracy of clinical staging has been evaluated. For multiregional lesions, the location that yielded the highest probability of metastasis was designated as the primary site. Our findings indicate inaccurate staging for 37% of glottic tumors, 38% of supraglottic tumors, 50% of transglottic tumors, and 13% of subglottic lesions. In 89% of the cases that were staged inaccurately, the error was one of underestimation. Depth of tumor invasion was the most difficult measurement to determine.

Humans↗
PubMed1979

A modified intraoral electrolarynx.

Most electrolarynx devices currently available are designed to be hand-held. The postlaryngectomy patient who cannot develop esophageal speech and requires the use of both hands is clearly handicapped by this design. We report a modification of the intraoral (Cooper-Rand) electrolarynx that is not hand-held.

Adult↗
PubMedDate not supplied

Mechanisms of hypercalcemia in patients with head and neck cancer.

Hypercalcemia associated with head and neck malignancy is not an uncommon occurrence; its causes are multiple. Eight hypercalcemic patients with head and neck malignancy were studied. Serum calcium, serum phosphorus, tubular phosphorus threshold, fasting calcium excretion, plasma 1,25-dihydroxyvitamin D, nephrogenous cyclic adenosine monophosphate (AMP), and immunoreactive parathyroid hormone were measured. Excessive dietary calcium administration in the form of an oral hyperalimentation preparation appeared to be the cause of hypercalcemia in 2 patients. Six patients demonstrated humorally mediated hypercalcemia. These patients resembled patients with primary hyperparathyroidism in having elevated nephrogenous cyclic AMP excretion and reduced proximal tubular phosphorus reabsorption, but they differed from patients with primary hyperparathyroidism by having normal levels of immunoreactive parathyroid hormone, markedly increased fasting calcium excretion, and strikingly reduced mean plasma levels of 1,25-dihydroxyvitamin D. These data strongly suggest that the humoral factor responsible for hypercalcemia in patients with head and neck cancer is not parathyroid hormone, and that patients with hyperparathyroidism can now be distinguished with confidence from those with malignancy-associated hypercalcemia.

Adult↗
PubMedDate not supplied

Treatment of laryngeal stenosis. A conservative new approach.

One of the most perplexing problems in laryngology is the treatment of laryngeal scar tissue. This can be supraglottic, glottic, or infraglottic. Two acceptable methods of treatment have been surgical and endoscopic. Endoscopic treatment consists of dilatation, excision of scar tissue with a laser, removal of scar tissue with insertion of a stent, and removal and scar tissue with injection of intralesional cortisone. Twelve cases are reported, treated with microscopic removal of scar tissue followed by voice rest and beclomethasone dipropionate (Vanceril) inhalations, a topical steroid. All twelve cases showed marked improvement measured by improved glottic opening and improvement of voice quality. Further evaluation of this method of treatment should be done as an auxiliary treatment to our present accepted regime of treatments in this troublesome condition.

Adult↗