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Biomedical subjects

H R Koch

Publications and source records attributed to H R Koch.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Cataract during intermittent hemodialysis. The influence of hypocalcemia on the development of opacities (author's transl)].

Twenty uremic patients on intermittent hemodialysis were followed up for lens changes over 4-53 months. Only one patient of 22 years with megaureters and megacystis developed bilateral anterior and posterior subcapsular cataracts during dialysis treatment. The morphology of these cataracts was similar to that of fresh hypocalcemic opacities. The patient had actually been hypocalcemic before the onset of the opacification. Possible reasons for the development of hypocalcemic cataracts during intermittent dialysis might be: 1. a reduced calcium-phosphate ratio due to phosphate accumulation, 2. a decrease of ionized calcium due to removed metabolic acidosis, and 3. a permissive effect of longer latencies.

Adult↗
PubMed1976

[Aging of the lens and cataract (author's transl)].

Lens opacities in old patients are usually classified as "senile cataracts". Since there are very distinct morphologic types of opacities it is evident that we have to deal with different types of triggers in discussing the cataractogenesis. A great variety of risk factors might act as triggers for the development of opacities in aged people, and there is no doubt that among them age changes of lens metabolism are the most important. These age induced changes of lens metabolism do not only influence the energy level of lens metabolism (energy concept of lens transparency), the trigger may as well be located within the protein synthesizing system or the processes responsible for maintaining normal protein conformation, further, an exogenous intoxication may also occur. Lack of normal human lenses of all ages suited for metabolic research and an undefined classification for instance, coloration of the cataractous lens) makes biochemical research with respect to the pathogenesis of senile cataracts almost impossible. Animal models (naphthalene cataract, tryptophane-deficiency, X-irradiation) suited for the purpose may well support the basic research of this subject, even if we have to assume certain species differences of lens metabolism.

Aging↗
PubMed1975

[Corticosteroid cataracts following kidney transplantation. Investigations on the influence of additional factors upon the development of opacities (author's transl)].

15 patients with kidney transplants were followed up for a period of 3 to 45 months. All but one developed lenticular opacities in the posterior subsapsular region. The opacities were classified according to their severity. It could be shown that the cataract index was correlated to the total amount of corticosteroids given. There is probably an additional effect of age and azathioprin therapy. Possibly, the time of treatment with intermittent hemodialysis also influences cataract development.

Adrenal Cortex Hormones↗
PubMed1975

[Monitoring the progress of lens opacities in cases of senile cataract by retro-illumination photography (author's transl)].

A follow-up study of lens opacities, utilizing retro-illumination photography with the fundus camera is described. After giving technical details, results are discussed and possible errors pointed out. If evaluation by planimetry or other devices is not possible, a useful procedure is the evaluation of simultaneous projected slides by a group of ophthalmologists not directly involved in the trial. This is demonstrated by testing the effect of 1-hydroxy-pyrido-(3,2alpha)-5-phenoxazone-3-carboxylic acid on the progress of senile cataract in a total of 48 eyes. Together with slit image photography of Brown (2, 3) the method of retro-illumination photography of the lens presented in this paper is a definite improvement in demonstrating the temporal course of cataract development.

Aged↗