Biomedical subjects
Publications and source records attributed to H R Chandrashekar.
A case of Chediak-Higashi syndrome is reported in a four-year-old boy who presented with recurrent chest infection, partial albinism, hyperpigmentation of the extremities and presence of giant granules in leucocytes and melanocytes in the skin. Parental consanguinity was present. Though uncommon, hyperpigmentation of sun exposed areas may be the initial symptom in Chediak-Higashi syndrome.
A 50 year old heterosexual male presented with fever and cough with expectoration of months duration, and swelling in the right testis. The serological tests showed positivity for HIV 1 and 11 antibodies. Testicular biopsy from the right testis showed epitheloid cell granulomas with central caseous necrosis and peripheral mantle of lymphocytes and plasma cells. Zeihl-Neelsen stain on tissue sections showed AFB positivity. To the best of our knowledge this is the second reported case of acquired immunodeficiency syndrome presenting as testicular tuberculosis.
A case of meningeal carcinomatosis following ovarian carcinoma is reported. The rarity of this occurrence is highlighted.
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A case of Hodgkin's disease who was found to have a hypoplastic lung on investigation is presented here. This co-incidence has not been reported earlier in the literature.
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A case of progressive systemic sclerosis in a 36 year old woman is reported. The systemic, clinical, radiological and oral manifestations have been discussed.