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Biomedical subjects

H Qureshi

Publications and source records attributed to H Qureshi.

At least 37 records · Page 2Linked to original sources
PubMed1999

H. pylori IgG antibodies in children.

OBJECTIVE: The aim of the study was to see the exposure rate to H. Pylori (IgG) in apparently healthy children. METHODS: Serum samples of 100 apparently healthy children aged 6 months to 10 years were screened for IgG antibodies against H. pylori using Abbott's flexpack kit. Children were divided into two groups, group I included aged 6 months to less than 5 years and group II aged 5-10 years. RESULTS: Of 60 children in group I, 17 (28.3%) showed antibodies against H. Pylori indicating exposure. The exposure rate was 12.5% between 6 months to 11 months, 28.5% in 12 months to 23 months and 38% in 24-36 months. Exposure rate increased with lowering of socioeconomic status; being 13.3% in upper, 26.9% in middle and 42.1% in lower socioeconomic group. Of 40 children aged 5 years to 10 years, 16 (40%) showed H. Pylori antibodies. The exposure rate was 34.3% at years and increased to 62.5% in those aged 8-10 years. The H. pylori positivity was 33.3% in upper and middle socioeconomic group and 62.5% in lower socioeconomic group. Over all exposure rate to H. Pylori in children was 33%. CONCLUSIONS: H. pylori exposure rate increased with the advancement of age and lowering of socioeconomic status. Early exposure might be related to the use of premasticated food by the mothers for feeding of children; dental plaque being the reservoir of infection in adults.

Adult↗
PubMed1999

Comparison of five different treatment regimens for H. pylori eradication.

AIM: Treatment response to five different H. Pylori eradication regimens were evaluated to see which is the best regimen in our setup. METHODS: Patients presenting with upper GI symptoms of acid peptic disease underwent upper GI endoscopy and an antral CLO test. All those with a positive CLO test were included in the study. The study was carried out over a year and one trial was followed by another. The treatment regimens comprised of (1) Omeprazole 20 mg once a day, colloidal bismuth subcitrate 120 mg three times a day, Metronidazole 200 mg three times a day (18 cases). (2) Colloidal bismuth subcitrate three times a day, furazolidone 100 mg three times a day, metronidazole 200 mg three times a day (28 cases). (3) Omeprazole 20 mg once a day, Clarithromycin 500 mg twice a day (21 cases). (4) Lansoprazole 30 mg once a day, Amoxycillin 500 mg three times a day (21 cases). (5) Lansoprazole once a day, Amoxycillin 500 mg three times a day and Roxithromycin 150 mg twice a day (14 cases). Therapy for all 5 groups comprised of 14 days. Endoscopy and CLO test were done prior to the entry in the trial and at 28 days to see the response. RESULTS: Meta analysis was done for all the 5 regimens. For the purpose of analysis patients were divided into 2 groups, i.e., those with peptic ulcer and positive CLO (peptic ulcer disease (PUD) and those without peptic ulcer but positive CLO test (Non ulcer dyspepsia (NUD). PUD was seen in 14 of 18 cases in group 1, 18 of 28 cases in group 2, 16 of 21 cases in group 3, 6 of 21 cases in group 4 and 3 of 14 cases in group 5. In PUD after 14 days of therapy, lesions healed and CLO became negative in 50% cases each in group 1 and 2, 56% in group 3, 83% in group 4 and all in group 5, while in NUD, 25%, 60%, 80%, 47% and 82% respectively showed H. Pylori eradication. CONCLUSION: Of the different therapies one proton pump inhibitor with two antibiotics gave best results in ulcer healing and H. pylori eradication in ulcer and non ulcer dyspepsia.

Anti-Bacterial Agents↗
PubMed1998

Collecting patients' views and perceptions of continence services: the development of research instruments.

This paper describes one part of a feasibility study carried out in England which examined the costs, quality and effectiveness of continence services in areas with different approaches to provision. It involved the design of instruments to collect the views and perceptions of patients and an investigation of ways to develop a methodology to implement comparative studies. It is the design and piloting of the questionnaires and the way patients responded that forms the focus of this paper. The main sample group recruited for the study were women who had recently sought formal help with urinary incontinence and were likely to receive conservative treatment or management in the community. They were interviewed and asked to complete four questionnaires at two points in time. A smaller sub-group of disabled women, interviewed only once, were included to compare cost profiles for different client groups. The questionnaires which were developed address the impact of urinary incontinence (using a standard scale), the effectiveness of service provision in terms of patients' clinical history, expectations and hoped-for outcomes, service receipt and its cost, and patients' satisfaction with several aspects of service provision. In total 118 women were interviewed, including 28 disabled women. The study generated a set of survey instruments which might be used for a variety of purposes including audit and future research and which could inform purchaser and provider decisions by using patients' perspectives of quality of life outcomes to enhance service development.

Attitude to Health↗
PubMed1998

Esophageal variceal banding--the local experience.

Banding of esophageal varices was done in 29 patients suffering from acute variceal bleeding. In 13 patients this was the first bleed while in 16 it was recurrent. Five patients had large grade III (polypoid) varices while others had grade II varices. Banding was done using multi band ligator and 4-6 bands were fired per session. Repeat endoscopy at 3 weeks revealed persistence of varices requiring second session of banding in 11 cases and small varices (difficult to band) in 9 cases. Two patients expired due to persistent bleeding and 2 bled from esophageal ulcers. Both patients settled with conservative treatment. A third session of banding was required in 5 cases only. None of the cases developed any major complication. In our setting where expertise for sclerotherapy is scarce and cost of sclerosants is high; banding appears to be a cost effective modality for the management of variceal bleeding with a low complication rate.

Adolescent↗
PubMed1996

Endoscopic re-evaluation of Visick grading.

Correlation of Visick grading was done with serial endoscopies in 19 patients operated for duodenal ulceration. Deeper mucosal lesions like ulceration showed good association with Visick grading (100%), while superficial mucosal lesions were mostly asymptomatic and therefore, caused disparity in grading. Moreover, as symptoms and endoscopic findings changed with passage of time, it was concluded that in the light of endoscopic findings the grading need re-evaluation.

Adolescent↗
PubMed1996

Triple therapy in duodenal ulcer healing--a follow up study.

Thirty-nine Helicobacter pylori (HP) positive chronic duodenal ulcer patients completed the 4 weeks treatment of triple therapy (Denol, Metronidazole and Amoxil). Of these 29 showed healed duodenal ulcer and negative CLO test at 8 weeks (eradication). They were followed at 3,6 and 12 months and at each follow-up, endoscopy and CLO testing were repeated. At 12 weeks, 54% showed a healed ulcer and negative CLO and these figures reached to 69 and 66% at 6 and 12 months respectively. Thirty percent relapsed within 1 year. The present study indicates a prolonged remission of duodenal ulcer following HP eradication.

Adult↗
PubMed1995

Healing and relapse rates of duodenal ulcer with omeprazole vs ranitidine.

The efficacy of omeprazole 20 mg a day was assessed against ranitidine 150 mg twice a day in the healing and relapse of duodenal ulcer. Forty three endoscopically verified cases were allocated to 2 weeks of treatment, which was extended to 4 weeks, if the ulcer persisted on day 15. Two cases were excluded due to deviation from the protocol. Of 41 evaluable cases, 21 received omeprazole and 20 ranitidine. Healing rates with omeprazole and ranitidine at 2 weeks were 71% and 70% respectively which rose to 100% and 90% at 4 weeks (N.S). There was no significant difference in pain relief in two groups. Follow-up endoscopies, in 33 healed cases revealed 100% relapse at 3 months in omeprazole and 79% in ranitidine treated cases (P < 0.05).

Adolescent↗
PubMed1995

Helicobacter pylori clearance and eradication with triple therapy in duodenal ulcer patients.

Triple therapy was given to 49 chronic helicobacter pylori positive chronic duodenal ulcer cases to see its efficacy in H. pylori clearance, eradication and ulcer healing. H. pylori clearance and eradication rates at week 5 and 8 were 87.8% and 81.5% while ulcer healing rates 68.2% and 81.5% respectively. Seven (18%) cases failed to clear H. pylori and were classified as non-responders. Histologically 60% showed post-treatment regression of gastritis. Tolerance to drugs was excellent with a good compliance rate.

Adult↗
PubMed1995

Famotidine 40mg B.I.D. in the treatment of reflux oesophagitis.

To assess the efficacy of famotidine in the healing of reflux oesophagitis, 25 endoscopically proven cases were treated with famotidine 40 mg B.I.D. for 6 to 12 weeks. Six patients were lost to follow-up, of the 19 cases analysed, 16 (84.2%) healed at 6 weeks and 17 (89.5%) at 12 weeks. Twelve cases (63%) became asymptomatic within six weeks of treatment. In conclusion famotidine 40 mg B.I.D. is effective in the healing of reflux oesophagitis.

Adolescent↗