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Biomedical subjects

H Pujol

Publications and source records attributed to H Pujol.

194 records · Page 11Linked to original sources

[Cancer of the thoracic esophagus. Therapeutic strategy].

Out of 100 patients with oesophageal carcinoma, 39 will have the tumour resected, 26 will survive the operation, and only 4 will be alive after 5 years. Although surgical resection is the best treatment for squamous cell carcinoma, new trends in pre-operative chemotherapy should provide better results. A therapeutic regimen based on data from the literature and on personal experience is suggested as neoadjuvant chemotherapy in operable and in nonsurgical tumours. Operability should be re-evaluated after 2 courses of chemotherapy according to response rate. Surgical possibilities and post-operative treatment depend on this response. Surgical procedures and the indications of surgery are described.

Combined Modality Therapy↗

[Coagulation disturbances after subtotal or total hepatectomy in the dog (author's transl)].

The authors relate 15 cases of blood coagulation disturbances among three groups of animals after 80%, 90% or total hepatectomy. Animals in group I, after 80% hepatectomy, were sacrified between the 10th and 30th postoperative days. Group II animals, with 90% hepatectomy, survived for periods ranging from 18 to 24 hours. In group III, after total hepatectomy, survival varied between 30 and 40 hours. The coagulation disturbances which were observed following 80% hepatectomy were spontaneously compatible with the survival of the animals. Following 90% and total hepatectomy the resulting disturbances were constantly severe enough to limit survival time. Supportive procoagulant therapy associated with sequential heparin administration seems justified by the insufficient biosynthesis of clotting factors and their unavoidable consumption as a result of localized then disseminated intravascular coagulation and secondary fibrinolysis.

Animals↗