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Biomedical subjects

H Prestele

Publications and source records attributed to H Prestele.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Prolactin in serum and anamnestic data of women with cystic disease of the breast (author's transl)].

78 women with cysts of the mammary gland--proved by aspiration of cystic fluid--had significantly more hyperprolactinaemia than 42 control-persons. Hyperprolactinaemia was twice as frequently found in 46 women with microscopic cystic disease--proved histological in biopsies--than in control-persons. On the average there was a moderate elevation of prolactin. Individual prolactin-levels were up to four or five times higher than normal. The comparison between prolactin and gynecologic data and anamnestic known endocrine and metabolic lesions was without significance. There was no relation between use of prolactin-stimulating drugs (psychopharmacas a.o.) and cystic disease of the breast. Patients with cystic disease used significantly less oral contraceptiva and more estrogens than control-persons. There was no familiar-genetic disposition significant. Our results show prolactin as an etiologic factor of (gross-) cystic breast disease.

Adolescent↗
PubMed1978

[Oral leukoplakia. II. Results of a year-long polyclinical pilot study].

A pilot study was carried out on close on 4000 uniformly examined and documented patients of the Erlanger maxillo-facial Policlinic. This resulted in the extensive collection of data useful as a basis for future follow-up studies on leucoplakia patients. Leucoplakia was found in 123 patients (3,1%) including 7 precancerous lesions and 6 mucosal carcinomata. Age and sex distribution of leucoplakia patients and various potential influential factors were statistically compared with a control group of an equal number of outpatients. For each of the factors examined, chronic smoking, chronic alcohol consumption, enoral habits, the connection with the occurrence of leucoplakia was highly significant (alpha less than 0,001).

Adolescent↗
PubMed1977

[Muscle bridges over the left anterior descending coronary artery: their influence on arterial disease (author's transl)].

A total of 711 hearts was studied and examined for coronary muscle bridges of the left anterior descending (LAD) macroscopically, angiographically and histologically. A muscular overbridging of the LAD was found in 22.9% of all hearts. The average distance from left artery bifurcation was 33.6 mm, the average length was 22.5 mm and the average thickness 2.8 mm. A thin layer of fat tissue is mostly to be found between the overbridged coronary artery and the myocardial bridge. The patient group with and without myocardial overbridging showed no difference in sex or age nor in average stature and the average heart weight. Statistically, there is significantly more atherosclerosis of the coronary artery proximal to the muscle bridge than there is under and distal to the bridge. A difference in frequency and extent of atherosclerosis in hearts with and without coronary muscle bridge could not be shown for this portion of the LAD. Nevertheless, there is a tendency for fewer anterior-wall infarctions in the patient group with a coronary muscle bridge of the LAD, because, when the whole branch is considered, there is a significantly lower incidence of atherosclerosis in hearts with myocardial overbridging of the LAD. The reason for the protective effect of a coronary muscle bridge is yet not clear.

Adipose Tissue↗
PubMed1976

[Effect of carbohydrate infusions on the formation of calcium oxalate deposits in the kidney: postmortem morphological and biochemical findings in humans and in animal experiments].

Histological and biochemical studies were carried out in a total of 300 patients who had died in the recovery room, and in rabbits, to investigate the frequency of deposits of calcium oxalte crystals in the kidneys, the influence of infusion therapy and the pathological significance of such deposits on the kidney tissue and on renal function. - Quite independent of any infusions, however, deposits of calcium oxalate crystals were found in the presence of kidney-specific diseases, in particular uraemia and anuric conditions. Xylitol infusions of 0.4 g/kg body weight or, in individual cases, of not more than 500 g total in 7 days, had no infllence on the appearance of calcium oxalate deposits. The blockage of the tubular system by the calcium oxalate deposits leads to a temporary reversible increase in serum urea and serum creatinine. With time, and uninfluenced by infusions, the deposits disappear out of the kidney again without having caused any organic renal damage. In the presence of a temporary excess of serum oxalate, the kidneys temporarily act like a cloaca.

Animals↗
PubMed1975

[Diurnal variation of glucose tolerance and insulin secretion in man (author's transl)].

The present investigation was designed to determine whether the circadian rhythm of glucose utilization is based on a quantitatively different release of insulin and/or on changing secretory dynamics of the hormone. 22 healthy men received three oral glucose tolerance tests in the morning, afternoon and evening of the same day. The blood sugar levels in the afternoon and evening tests were significantly higher than those found in the morning tests. Also the plasma insulin response was higher in the afternoon than in the evening, but it showed a delayed rise and late peak response. In the evening the normal subjects responded as mild diabetics.

Adolescent↗
PubMed1975

[Chromosome investigations in subjects with occupational lead exposure (author's transl)].

The lead content in blood, the excretion of delta-aminolaevulinic acid (ALA) in urine, and the ratio of secondary chromosomal aberrations in lymphocyte cultures were investigated in 105 workers with varying degrees of lead exposure. While the mean lead content was slightly increased (377 plus or minue 207 mug/l) the mean ALA excretion was normal (3,8 plus or minus 4.7 mg/g creatine). Chromosome investigations showed a slightly increased rate of cells with structural abnormalities (14,1 plus or minus 7.0%). Statistical evaluation of these data showed no significant correlation between the lead content in blood, ALA excretion in urine, and cytogenetic findings. No other reason for the increased rate of chromosomal aberrations could be detected.

Aminolevulinic Acid↗
PubMed1975

[Activity of enzymes of galactose metabolism in so-called congenital cataract (author's transl)].

Activity of galactokinase (69 subjects) and galactose-1-phosphate uridyl transferase (92 subjects) were measured in haemolysed blood from children (predominantly of school age) with congenital cataract. chi2 tests, gene-frequency determination and metabolic-kinetic studies indicated that the changes in the lens in congenital cataract are partly due to a manifest or latent disorder of galactose metabolism, in particular a glactose-1-phosphate uridyl transferase defect.

Austria↗
PubMed1975

[Normal values for Lactate- and Glutamate dehydrogenate by new optimized methods (author's transl)].

The activities of the enzymes LDH (Lactatdehydrogenase), HBDH (Hydroxybutyratdehydrogenase), and GIDH (Glutamate dehydrogenase), as well as LAP (Leucine aryl peptidase) were measured in the serum of 934 children in order to get normal values of these enzyme activities in dependence on the age. We used again the optimized methods (Boehringer und Merck). The form of the distribution of the single values of these 4 enzymes can be described by a lognormal distribution. This applies not to newborns and young sucklings. All measured enzyme activities were depended on the age of the children; newborn and sucklings had significantly higher enzyme activities than infants. After the second year of life the enzyme activities for LDH, HBDH, GlDH and LAP remained constantly. The physiological variations are very high in the newborns. The diagnostic selectivity of the enzyme GIDH is very good, this of LDH and HBDH turned out unspecifically. No difference could be supplied for the sex of the children.

Adolescent↗
PubMed1975

Fractionation of antigen reactive cells from immunized mice on columns coated with antigen or anti-immunoglobulin sera.

Immunocompetent cells obtained from NIP-RGG immunized mice were fractionated on bead columns coated with antigen or anti-immunoglobulin serum. The separated cell fractions were examined for their capacity to be stimulated by the antigen in short term culture, to produce antigen specific antibodies in the plaque assay and to bind radioactive labeled antigen. Cells which produce hapten specific antibodies or bind radioactive labeled hapten are removed from the cell population passed through a hapten-carrier complex coated column. Cells stimulated by the antigen to an increased DNA-synthesis are also retained by columns coated with the hapten-carrier-complex or the carrier alone; the fractionation seems to be carrier specific. The fractionation of cells is blocked by free antigen in the columnar fluid. However, the fractionation patterns of cells passed through anti-Ig-serum coated columns are different when antibody producing cells and cells stimulated by the antigen are compared. Whereas antibody producing cells and antigen binding cells are almost completely retained by anti-Ig-serum coated columns the cells which are stimulated by the hapten carrier complex are not removed from the passed cells. Studies to characterize the fractionated cell populations according to their sensitivity to anti-theta-serum, to the presence of Ig-receptors and to the phytohemagglutinin stimulation indicate that the antibody producing cells and the antigen binding cells have to be attributed to B-cells whereas the question whether the antigen stimulated cells are T- or B-cells cannot be definitely answered.

Animals↗
PubMedDate not supplied

[Myocardial electrolytes in "cardioplegic" myocardosis (author's transl)].

Changes of the mineral concentrations of the heart muscle can point at disturbances of myocardial metabolism. Disturbances of heart muscle with functional loss and without coronary or inflammatory heart disease are called myocardosis, especially cardioplegic myocardosis after open-heart surgery with extracorporal bypass. 30 dogs were examined in three groups varying the method of induced cardiac arrest: 1. ischemic cardiac arrest by clamping the ascending aorta, 2. functional cardiac arrest by electrically induced fibrillation and 3. ischemic cardiac arrest and in addition injection of a Mg-aspartate-procain-solution. Sodium, potassium, magnesium, calcium, copper and zinc were analyzed by atomic absorption spectrophotometry. Specimens from the left and right ventricular wall were examined before and after extracorporal circulation. After a recovery period for one hour the dogs were killed and specimens from the right and left ventricular wall and from the basis and apex of the interventricular septum were taken and reduced to ashes with mineral acids. In all animals changes of the mineral content were most marked after the recovery period. In all forms of cardiac arrest mineral metabolism showed monotone reactions: water content increased, potassium and magnesium decreased. Variations of mineral concentrations were more expressed in the right ventricular wall than in the left. Animals with cardiac arrest by electrically induced fibrillation indicated the smallest deviations from the basic values. The comparison of the values of dogs with sufficient circulation at the end of the experiments and those dogs with medicamentally or mechanically supported circulation at this time showed a more increased water content and simultaneously a decrease of all cations in the group with supported circulation. The decrease of the osmolality of the cations seems to be the metabolic answer to the increased cardioplegic damage of heart muscle.

Animals↗