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Biomedical subjects

H Prange

Publications and source records attributed to H Prange.

At least 19 recordsLinked to original sources
PubMed1994

[Bacterial CNS infections in adults in Southern Lower Saxony. A retrospective study of the Göttingen Neurologic University Clinic].

All 155 patients with suspected bacterial central nervous system (CNS) infections treated from 1986 to 1991 at the Department of Neurology, University of Göttingen, were evaluated in a retrospective study. According to the clinical symptoms presented at admission, 7 cases were classified as encephalitis, 44 as meningitis, 15 as radiculitis, 19 as ventriculitis, 61 as meningoencephalitis and 9 as meningoradiculitis. In 78% of these cases, the causative bacteria were either isolated from cerebrospinal fluid (CSF), or other relevant sources (blood, wound swabs) or identified by serological methods; (all cases of CNS borreliosis, and 3 of the 5 cases of listeriosis were identified by means of the last mentioned method). CNS infections caused by staphylococci and Borrelia burgdorferi were most frequent, followed by those due to pneumococci, meningococci and other streptococci. CNS infections caused by Mycobacterium tuberculosis, Listeria monocytogenes, Haemophilus influenzae and enterobacteriaceae were less frequent. In comparison to the CNS infections due to other bacteria, the pneumococcal and meningococcal meningitic infections were associated with more pronounced CSF alterations (on the average, there were higher white blood cell counts, and higher CSF protein and lactate). Pneumococci predominated in older patients and those with an impaired immune system, or infections of organs neighboring the CNS. Meningococci were most frequent in young and previously healthy individuals. All patients with CNS listeriosis had predisposing conditions. Meningococcal meningitis was either fatal or resolved with or without minimal neurological deficits. Infections caused by staphylococci or pneumococci were associated with a high percentage of neurologic sequelae.

Adolescent↗
PubMed1991

Nitrate-induced hypothyroidism is associated with a reduced concentration of growth hormone-releasing factor in hypothalamic tissue of rats.

Dietary nitrate significantly inhibits the growth of male and female rats. To test the possibility that the growth hormone-releasing factor (GRF) content in hypothalamic tissue is deranged under these conditions, male and female rats were fed a diet containing 3% KNO3 for 6 weeks, compared to a normal diet (4 X 5 animals). The food intake of rats fed nitrate was reduced significantly (23 and 28% resp.). Weight gain was also decreased by 35 and 41% in male and female rats. The mean Sm-C/IGF-I concentration was 1.61 and 1.03 rU/ml in male and female control rats, whereas the concentrations in nitrate-exposed rats were 0.92 and 0.64, respectively (P less than 0.01). The GRF content of hypothalamic tissue also decreased significantly from 407 and 533 ng/g protein in controls to 174 and 229 in treated male and female rats. Nitrate exposure is characterized by hypothyroidism, food intake depression, low Sm-C/IGF-I concentrations in plasma and a decreased hypothalamic GRF content. Independent of the peripheral changes, the content of Sm-C/IGF-I in the brain remains constant. The results of the study demonstrate that thyroid hormone deficiency leads to an inhibition of GH axis already at the hypothalamic level.

Animals↗
PubMed1988

Heparin therapy, deep-vein thrombosis and pulmonary embolism after intracerebral hemorrhage.

A prospective randomized pilot study of subcutaneous low-dose heparin in the prevention of deep-vein thrombosis and pulmonary embolism was carried out in patients admitted to hospital after intracerebral hemorrhage. A high incidence of deep-vein thrombosis and lung embolism was detected by phleboscintigraphy and lung perfusion scintigraphy, respectively. There was no significant reduction of deep-vein thrombosis and pulmonary embolism in the therapy group. Heparin did not increase the risk of rebleeding.

Cerebral Hemorrhage↗
PubMed1987

A case of valproate intoxication with excessive brain edema.

A 29-year-old man, who had been treated with sodium valproate for 3 years because of generalized cerebral seizures, ingested a large amount of this drug in an attempt to suicide. The exact amount he had swallowed could not be determined. The patient arrived in the intensive care unit in a deep coma, was intubated, and artificially ventilated. He developed a massive cerebral edema, as proved by computerized tomography (CT). This was supported by electroencephalography (EEG). The measured value for the concentration of valproate in serum was markedly elevated on the day of admission (2300 mumol/l; therapeutic range 350-700 mumol/l). Treatment with sodium thiopental, glycerol, and glucocorticoids was initiated. A second CT scan performed 9 days after admission showed a complete normalization and the EEG yielded a markedly improved pattern. At this point the patient slowly regained consciousness. We conclude that in patients with an acute sodium-valproate intoxication, care should be taken with regard to the development of a severe cerebral edema, which in the reported case could be treated successfully.

Adult↗
PubMed1986

[Rhabdomyolysis as a complication of chronic alcoholism. Observations in 19 cases].

In 19 chronic alcoholics with rhabdomyolysis the clinical picture demonstrated markedly different degrees of severity of myolysis. Muscle pain, muscle swellings and brown-coloured urine were rare. But symptoms of delirium, at times with cerebral seizures, were frequent at the onset. Renal failure of different degrees was common; five patients had to be dialysed. Two patients died in irreversible shock. Respiratory insufficiency and hypercalcaemia were other complications. Early recognition of the disease is important, because early treatment can prevent acute "myoglobinuric" renal failure.

Adult↗
PubMed1985

[Practically relevant electrodiagnosis in facial and recurrent nerve pareses. A review].

Following a general description of pathophysiological changes of an injured peripheral nerve, a survey is presented in which those electrodiagnostic tests that are of practical relevance today in cases of facial and recurrent nerve pareses, are defined and the methods used are described (electromyography, neuromyography, blink reflex, reflex myography of the larynx). Typical electrodiagnostic findings are explained and demonstrated, using examples from our own case material. The relative merits and diagnostic efficiency of separate and combined findings are discussed.

Blinking↗
PubMed1983

Visual evoked potentials in neurosyphilis.

The visual evoked potential (VEP) to pattern reversal was recorded in 79 patients with neurosyphilis. Sixteen patients (20%) had abnormal VEP latencies with a predominance of pathological VEP values in the group of tabes dorsalis (50%) as compared to general paresis (18%) or meningovascular forms (13%). A comparison of the frequency of abnormal VEPs with that of other ophthalmological tests (visual acuity, visual field, central campimetry, pupillary reactions, dark adaptation, optic fundus) yielded no diagnostic superiority of VEP.

Adult↗
PubMed1983

[The lipoprotein status of fetal minipigs].

VLDL, LDL and HDL of fetal minipigs were isolated by preparative ultracentrifugation from serum at term. Concentration and lipid composition were evaluated in the fractions and compared with the corresponding data obtained in the adult animal. The concentration of VLDL lipids in fetal serum amounts to 50% (p less than 0.05), that of HDL lipids to 63% (p less than 0.01), and that of LDL lipids to 75% (n. s.) of the values seen in adult minipigs. With the exception of the increased cholesterol content of fetal VLDL there were no significant differences in the composition of the density classes between fetuses and the adult animals. Our results demonstrate a general difference between the lipoprotein pattern in the fetal state of minipigs and of human beings brought about, in particular, by the pronounced disparity of the materno-fetal gradient of VLDL, LDL, and HDL.

Aging↗
PubMed1982

[Surgical reduction of the kidney for inducing chronic kidney insufficiency].

By operative reduction of the renal tissue on 1/5 of both kidneys there are to be produced a chronic renal insufficiency in 21 black mini-pigs. The operative procedure was carried out at one time (nephrectomy and resection of the residual kidney) or at two times (in one group of it at first the nephrectomy and in the other group at first the resection of the kidney). Only 50% of the animals died with the symptom uremia in renal insufficiency. The nephrectomy--with a temporarily shifted resection of the residual kidney--effects the desired changes most approximately with very different reaction. This procedure appears as an animal model for the chronic renal insufficiency altogether not suitable.

Animals↗