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Biomedical subjects

H Pourquier

Publications and source records attributed to H Pourquier.

At least 55 records · Page 3Linked to original sources
PubMed1976

Total abdominal irradiation and parenteral nutrition: an experimental study in the dog.

The influence of parenteral nutrition on digestive tolerance was studied in 26 dogs receiving total abdominal irradiation, (1 110 rads were delivered in a single dose at mid-thickness of the abdomen). We studied enzymatic perturbations (lactase, maltase, alkaline phosphatase and enterokinase) in the duodenum, jejunum and ileum and we observed a correction of the 75% decrease of the intestinal enzymatic activities after total abdominal irradiation in the dogs fed exclusively by parenteral routes while the dogs fed orally died in few days with severe digestive and metabolic disturbances.

Abdomen↗
PubMed1976

[The failures of the exclusive physiotherapy of carcinoma of the uterine cervix. Study of their topography and their causes].

In a series consisting of 400 cases of carcinoma of the uterine cervix, the authors encountered a therapeutic failure rate of 43,5%-5,8% were due to advanced localized disease, 29,4% to locoregional recurrence, and 8,3% to tardive isolated metastases. Of the 126 recurrences, 25 were localized to the cervix or vagina, 67 were elsewhere within the pelvis, and 34 were both localized and pelvic. These recurrences, more frequently found in the advanced stages of cervical neoplasia, are usually due to insufficient external or internal irradiation of the parametria or central part of the pelvis. The current methods of external irradiation using high energy sources in combination with curietherapy using a more appropriately suited material tend to decrease the failure rate due to insufficient irradiation.

Female↗
PubMed1975

[Exclusive radiotherapy (cobalt teletherapy-radium therapy) in epithelioma of the uterine cervix. 400 cases treated between 1959 and 1969].

The author presents results of 420 cases of epithelioma of the cervix of the uterus treated between 1959 and 1969, using exclusively physical agents such as cobalt therapy and radium therapy. 399 cases are analysed. 9 patients could not be traced and 12 died intercurrently. We have adopted the 1969 U.I.C.C. classification. External irradiation alwyas preceded radium therapy and its importance varied according to the stage: however, doses of 2,000 to 5,000 rads were used at the rate of 1,000 rads weekly for two to five weeks; this was followed by classical radium therapy (Paris method) with colpostat and uterine sound. The number of mgh was consequently reduced and the dose administered was inversely proportional to that of the external irradiation. On the whole, tolerance was good in this type of treatment. Complications were mainly limited to a few minor intestinal disorders; in belated sequelae, these disorders were not more than those usually noted. Results after five years reveal only one death out of 19 for stage T1 lesions. Recoveries are distributed as follows: 72 out of 93 stage T2a lesions (77%), 46 out of 87 stage T2b lesions (53%), 54 out of 131 stage T3a lesions (41%) and 13 out of 46 stage T3b lesions (28%). However, results according to period are better. For the 1967 to 1969 period, results were 92%, 62%, 53% and 30% for stages T2a, T2b, T3a and T3b respectively. Improvement in results could be due to external irradiation. This sterilizes pelvic macroscopic or microscopic extensions and decreases inflammatory phenomena and the volume of the cervix of the uterus. These changes facilitate radium therapy which remains an indispensable arm for sterilizing primary lesions. The author compares his results with those of the literature. He develops arguments for techniques which associate external irradiation and radium therapy in a well defined order. These techniques are particularly important for stages T2b or T3 in which lymph gland lesions are common and where doses of about 5,000 and 6,000 rads are necessary for sterilization. Possibilities of improving future results are analysed. Particular attention should be paid to the lumbo-aortic volume; lymph gland metastasis are frequent here and should be treated continuously with the pelvic volume.

Cobalt Radioisotopes↗