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Biomedical subjects

H Poppius

Publications and source records attributed to H Poppius.

At least 55 records · Page 3Linked to original sources
PubMed1977

A new ear oximeter for assessment of exercise-induced arterial desaturation in patients with pulmonary diseases.

Changes in arterial oxygen saturation during exercise were measured with a new eight-wavelength ear oximeter and calculated from blood gas measurements on simultaneously drawn arterial blood samples from 48 patients with pulmonary diseases. When the calculated oxygen saturation during exercise was more than 80% there change in oxygen saturation (SEE 1.0%). This non-invasive, simple and rapid method seems to be clinically useful for detecting the development of significant arterial hypoxaemia during exercise in patients with pulmonary diseases.

Ear, External↗
PubMed1977

Changes in arterial oxygen saturation in patients with hyperreactive airways during a histamine inhalation test.

The arterial oxygen saturation (SaO2) of 55 adult patients with hyperreactive airways was monitored with an eight-wavelength ear oximeter during a histamine inhalation test. The post-challenge fall (mean +/- s.d.) in peak expiratory flow was 38 +/- 15% of the baseline value; it was accompanied by a fall in SaO2 of 1.1 +/- 1.8 per cent, from 96.6 +/- 1.8 to 95.5 +/- 2.3%. It is concluded that, in the histamine inhalation test used in this study, even the development of marked bronchoconstriction usually causes only slight changes in SaO2.

Adult↗
PubMed1976

Effects of intravenous histamine on static lung compliance and airway resistance in normal man.

Static lung compliance and airway resistance were measured in 30 experiments on 6 healthy subjects after intravenous injection of a bolus of histamine (4 mug per kg of body weight). Analysis of the pooled results showed a significant decrease in static lung compliance (maximal mean decrease,--16 per cent occurring 20 sec after injection). There was no significant change in functional residual capacity or vital capacity after injection of the histamine. Administration of propranolol (a beta-adrenergic blocking agent) did not significantly enhance the responses to histamine. The results suggested that humans, like other species, can constrict peripheral airways sufficiently to produce alterations in the static elastic properties of the lungs.

Adult↗
PubMed1975

Double-blind cross-over comparison of clenbuterol and salbutamol tablets in asthmatic out-patients.

A double-blind cross-over comparison of a new beta2-sympathomimetic bronchodilator, clenbuterol, with salbutamol and placebo has been made during a 24 day period of out-patient treatment of 19 adults with moderately severe asthma. Oral clenbuterol (10 mug 3 times a day) and salbutamol (4 mg 3 times a day) were equally and significantly (p less than 0.001) more effective than placebo, when daily records of peak expiratory flow or use of isoprenaline inhalations were the criteria of activity. Daily records of symptoms according to a questionnaire also suggested relief of the subjective effects of asthma during treatment with both active drugs (p less than 0.01).

Adrenergic beta-Agonists↗
PubMed1975

Arterial to end-tidal CO2 difference in respiratory disease.

The difference in CO2 tension between arterial blood and end-tidal alveolar gas (a-end-tidal)DCO2 was found to correlate fairly well with the VD/VT ratio in 13 healthy subjects and 50 patients with pulmonary diseases (r = 0.74), and to discriminate between healthy subjects and patient groups at least as effectively as did the VD/VT ratio. An increase in breathing frequency from 8 to 32/min, without simultaneous change in alveolar ventilation, was associated with a mean increase in (a-end-tidal) DCO2 of several mmHg in both the healthy subjects and the patient groups. It is concluded that measurement of (a-end-tidal)DCO2 seems to be a clinically useful alternative to measurement of VD/VT ratio for evaluation of the wasted ventilation component, provided that the effect of the breathing frequency on (a-end-tidal) DCO2 is taken into account.

Adult↗
PubMed1970

Exercise asthma and disodium cromoglycate.

Exercise-induced asthma (defined as a fall in PEF of at least 25% of the pre-exercise value) was studied in adult patients with uncomplicated asthma. This was found to occur in 22 out of 52 patients. Pre-exercise inhalation of disodium cromoglycate reduced the mean fall in PEF after maximal exercise from 50% of the pre-exercise value to 23% (open assessment in 11 cases). After submaximal exercise for eight minutes the reduction was from 18% to 10% (double-blind crossover study in 28 cases). It is concluded that disodium cromoglycate partly inhibits the increase of airways resistance after exercise in asthmatic patients.

Adolescent↗