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Biomedical subjects

H Plenk

Publications and source records attributed to H Plenk.

At least 109 records · Page 6Linked to original sources
PubMed1976

Further experimental and clinical experience with aluminum oxide endoprostheses.

This paper describes the design principles of a new endoprosthesis made of dense aluminum oxide (A12O3) and implanted without bone cement. Mechanical tests and animal experiments have proved the sufficient mechanical strength of the bone-prosthesis connection as well as the biocompatibility of the material. So far, 12 tumor patients selected according to strict indication criteria have been operated on. Both the clinical-radiologic and the first histological findings available are encouraging. Special reference is made to the first fully ceramic total hip joint endoprostheses implanted in a human without bone cement.

Aluminum↗
PubMed1976

[Osteolathyrism. Quantitative-morphological studies on the experimental rat skeletal disease].

In young growing rats, fed the lathyrogenic agent aminoacetonitrile for 3 weeks, characteristic skeletal changes developed resembling the chronic state of osteolathyrism. In both lathyritic and untreated control rats, the femoral head, the distal end of the femur, the proximal tibial end, the thalocalcanean joint and the first lumbar vertebra were investigated using undecalcified thin sections and ground sections. The following methods were employed: quantitative morphometrical analysis of bone structure and bone remodelling of the lumbar vertebra, histochemical demonstration of the composition of polysaccharides, detection of the course of collagenous fibres in cartilage and bone by the polarizing microscope, tetracycline-labelling and fluorescence microscopical determination of epiphyseal longitudinal growth and bone formation activity, photometrical quantification of microradiographies and computer-aided determination of the mineral content of bone.

Aminoacetonitrile↗
PubMed1975

[Quantitative morphological analysis of bone remodelling in an experimentally-induced skeletal disease (author's transl)].

In the lumbar vertebrae of lathyritic rats bone remodelling was investigated using histomorphometrical and tetracycline labelling methods and a newly developed, computer-aided photometrical quantitation of mineral densities in microradiographs. The morphometrical analysis showed a high-graded decrease in cancellous bone due to increased resorption and cessation of endochondral bone formation. On the other hand, increased formation of new bone in sites of muscular insertion led to the formation of exostoses. Disturbed mineralisation of the newly-formed bone is indicated by increased osteoid volume and diffuse labelling with tetracycline. These findings were confirmed by the quantitation of the mineral densities. The mineralisation defect is related to the disturbed collagen synthesis in lathyrism.

Animals↗
PubMed1975

Quantitative measurement of delayed hypersensitivity in the guinea pig paw.

To facilitate quantitative measurement of a delayed hypersensitivity reaction, a tuberculin reaction was produced in the paws of sensitized guinea pigs and the resulting edema estimated by one of the usual techniques. The edema formation was shown to be an expression of the delayed hypersensitivity reaction. Optimal conditions for this reaction were assessed. This model may be used for testing the influence of drugs on delayed hypersensitivity reactions.

Animals↗
PubMed1975

[Occurrence of a special type of "polypoid cushion" and valve-like formations in arteries].

Intraarterial structures, known as 'polypoid cushions' and 'valve-like' projections at arterial branching sites, were observed in serial sections of human cleft lip and nasal mucous membrane biopsies. A particular type of 'polypoid cushions', which additionally contains a small artery in its center, is distinguished. It is suggested that both the particular type of 'polypoid cushions' and these 'valve-like' projections originate from the invagination of the entire vessel wall at arterial branching sites according to the location of the dissection or damage. The differences between these 'valve-like' formations and genuine arterial valves are mentioned.

Arteries↗