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Biomedical subjects

H Pinkus

Publications and source records attributed to H Pinkus.

At least 19 recordsLinked to original sources
PubMed1979

Factors involved in skin carcinogenesis.

A personal account of skin carcinogenesis is given based on forty years of investigation of normal and pathologic anatomy of the human skin. Symbiosis of acral portions of adnexa and of melanocytes with epidermal keratinocytes is stressed, and perversion of symbiosis to parasitism in tumor formation is discussed. The role of the basement membrane as a combined effort of, and filter between, ectoderm and mesoderm is stressed, and the nature of basal cell epithelioma as the least differentiated member of the tribe of fibroepithelial adnexal tumors is outlined. Experimental data supporting the promoting role of specific mesodermal stroma in basalioma formation and maintenance are presented.

Basement Membrane↗
PubMed1979

Volar melanotic macules.

Asymptomatic light brown or tannish-gray macules are seen on palms and/or soles of black patients, and occasionally on the volar surfaces of whites. They may be mistaken for lesions of secondary syphilis or other postinflammatory hyperpigmented dermatoses. Histologic examination of 14 specimens obtained at necropsy showed purely epidermal hyperpigmentation of all epidermal layers; or (3) melanin restricted to large dendritic melanocytes without appreciable transfer to keratinocytes. The number of melanocytes was not significantly increased, and with one exception, there were no nevus cells. These volar melanotic macules have close clinical and histologic resemblance to melanotic macules observed occasionally on the vermillion area of the lips.

Adult↗
PubMed1979

Furuncle.

Microscopic pictures of furuncles are rare in dermatologic literature. This report illustrates features of a furuncle that was completely excised. There was destruction of the epidermis, remnants of the involved hair follicle within an area of tissue necrosis, a large abscess with many polymorphonuclear leukocytes and small clusters of Staphylococci. The contrast with an uninvolved hair follicle observed in the vicinity of the furuncle was striking.

Furunculosis↗
PubMed1978

Large cell acanthoma. One of the actinic keratoses.

Large cell acanthoma (LCA), which was first introduced to the dermatologic literature in 1970 and has had no major presentation since then, is not an uncommon lesion. The lesion is a circumscribed hyperkeratotic epidermal growth with the outstanding pathologic feature being large cells. Clinical diagnoses have included several benign and malignant skin conditions. Large cell acanthoma may be related to lichen planus-like keratosis and lentigo senilis. We diagnosed 38 instances of LCA among 34,000 specimens received in our dermatopathology laboratory.

Adult↗
PubMed1978

Differential patterns of elastic fibers in scarring and non-scarring alopecias.

Elastic fiber stain (acid alcoholic orcein) reveals diagnostically significant differences between several types of alopecia of the scalp. A short outline of elastic fiber distribution on the normal hair follicle emphasizes the elastic coat of the follicular isthmus, the sparsity of elastic fibers on the cyclic lower portion of the hair root, and the presence in the neck of the dermal papilla of an elastin-like body which is formed anew with each hair cycle. This body provides a marker of the gradual shortening of successive anagen hairs in male pattern alopecia. Patterns of elastic fibers in the perifollicular and interfollicular dermis are helpful in differentiating idiopathic pseudopelade of Brocq from pseudopeladic states secondary to lupus erythematosus and other disease processes. Within the idiopathic group, the development of elastic fibres on the lower cyclic portion of the hair root identifies a sub-group that may have a different, non-inflammatory pathogenesis and is provisionally designated as fibrosing alopecia.

Alopecia↗
PubMed1977

Venereal warts vs Bowen disease. A histologic and ultrastructural study of five cases.

Verrucous growths of the genitalia in young patients are usually condylomata acuminata. In five cases this type of genital lesion, viewed by light microscopy, showed dysplastic cellular changes of Bowen disease, a diagnosis that was further confirmed by electron microscopy. Bowen disease should be included in the differential diagnosis of verrucous lesions of genitalia in young people and should be ruled out by histologic examination.

Adult↗
PubMed1977

Trichoadenoma of Nikolowski.

Trichoadenoma of Nikolowski is a rare benign tumor of the skin with hair follicle-like direction of differentiation. This tumor is less mature than trichofolliculoma and more differentiated than trichoepithelioma. Probably because of its rarity it has not been a well recognized tumor. We are reporting on eight cases of trichoadenoma to further define this benign growth.

Adenoma↗
PubMed1977

Multiple fibrofolliculomas (Birt-Hogg-Dubé) associated with a large connective tissue nevus.

Multiple follicular tumors of the type recently described by Birt and colleagues as fibrofolliculomas were observed in the dorsal skin of a white man in association with a large connective tissue nevus. No signs of systemic disease or phakomatosis were present. This type of lesions represents benign neoplasia of the fibrous root sheath of the hair follicle in association with proliferations of the infundibular portion of the outer epithelial root sheath. Its existence supports the view that the mesodermal portions of the pilar apparatus can become neoplastic, and also provides another example of the close interactions existing between the ectodermal and mesodermal components of the hair follicle.

Hair↗
PubMed1977

Eruptive vellus hair cysts.

Two children had a hyperpigmented monomorphous papular eruption of several years' duration. Biopsy specimens demonstrated cysts in the middle dermis that contained multiple fragmented vellus hair shafts. The eruption in one child involuted spontaneously. The cause of these lesions is obscure. The term eruptive vellus hair cysts is proposed for this entity.

Biopsy↗
PubMed1976

Histopathological spectrum of erythema multiforme.

Lesions of erythema multiforeme from seventy-five patients have been studied histologically. In addition to peculiar intercellular epidermal oedema, subepidermal separation and a lymphohistiocytic inflammatory infiltrate in the papillary dermis, epidermal cell necrosis was observed in a variable percentage of the lesions. While dermal disturbance was a predominant finding in the macular lesions, focal or generalized keratinocytic necrosis was seen in the macular, papular, bullous and iris lesions in that order of frequency. Significant numbers of eosinophils were present in the inflammatory infiltrate in 60% of the bullous and 28% of the macular lesions. Our findings suggest that erythema nultiforme represents a tissue reaction with spectral expression, one end presenting as a predominantly dermal disturbance and the other merging into the adult type of toxic epidermal necrolysis. Yet, the histological features remain sufficiently characteristic for differentiation from other erythematous and vesiculobullous eruptions.

Edema↗