Biomedical subjects
H Perrot
Publications and source records attributed to H Perrot.
Faecal porphyrin excretion in various types of porphyria. Thin layer chromatographic study.
A new method of thin layer chromatography was used for the study of faecal porphyrins in 31 porphyric patients (20 cases of porphyria cutanea tarda, 5 cases of porphyria variegata, 2 cases of hereditary coproporphyria, 1 case of acute intermittent porphyria and 3 cases of erythropoietic protoporphyria), 14 of their clinically normal relatives and 5 controls. The pattern obtained was characteristic of each type of porphyria and compared to previously published data.
Hyperpigmentation after bleomycin therapy. Ultrastructural study.
Pigmentation in a Causasian male, resulting from bleomycin therapy for Hodgkin's disease, has been studied ultrastructurally. The melanocytes, though present in normal numbers, showed several abnormalities; the endoplasmic reticulum and the Golgi apparatus were were well developed and the mitochondria were enlarged. Lipid inclusions in the endoplasmic reticulum and numerous autophagocytic vacuoles, some containing lipids were observed. Transfer of melanosomes to keratinocytes appeared to be increased. The melanosomes, which measured less than 0.55 mu were dispersed in the cytoplasm and did not form complexes, as has been observed with nitrogen mustard. The increase of melanocytic activity and the disturbance of melanosome transfer are discussed.
Unilateral nevoid telangiectasia.
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[Immunocytological study of cutaneous malignant lymphomas. Classification (author's transl)].
The malignant cutaneous lymphomas come into the category of hematodermias but can equally be considered as an abnormality of the immune system. Having described the methods used in the immunocytological investigation of 21 lymphomas and 3 pseudolymphomas, the authors expound their classification of malignant cutaneous lymphomas before stating the results obtained in immunocytological studies in each of the groups. They show how formal separation between epidermtropic malignant cutaneous lymphomas and non-epidermotropic malignant cutaneous lymphomas can be confirmed by immunocytological and ultrastructural facts.
[Generalized lymph node sarcoma during course of an actinic reticuloid (author's transl)].
A 50 year old man with actinic reticuloid developed a diffuse malignant lymphoma 7 years after the beginning of the dermatosis. Biopsy of lymph node showed a polymorphic proliferation with lymphocytes, numerous reticular cells and several Sternberg-like cells. An ultrastructural study showed an indifferentiate lymphocyte proliferation and numerous malignant reticular cells without the Sternberg cell picture. In this patient we discuss the role of immunosuppressive therapy, chronic herpes virus infection and chronic antigenic photostimulation. Up to now, this is the third case of an association between actinic reticuloid and malignant lymphoma.
[Immunological characterization of malignant epidermotropic lymphoma cells in cutaneous infiltrates (author's transl)].
Immunological characterization of cells in the malignant epidermotropic lymphomas requires techniques which define the lymphocytic nature of the cells, and for the lymphocytes techniques which demonstrate subpopulations of T or B cells. The results obtained using such methods in patients with cutaneous lymphomas are reported. The predominantly thymodependent nature of the cells of epidermotropic lymphomas is confirmed and the existence of a thymodependent non-epidermotropic cutaneous lymphoma is demonstrated.
Faecal porphyrin excretion in various types of porphyria. Thin layer chromatographic study.
A new method of thin layer chromatography was used for the study of faecal porphyrins in 31 porphyric patients (20 cases of porphyria cutanea tarda, 5 cases of porphyria variegata, 2 cases of hereditary coproporphyria, 1 case of acute intermittent porphyria and 3 cases of erythropoietic protoporphyria), 14 of their clinically normal relatives and 5 controls. The pattern obtained was characteristic of each type of porphyria and compared to previously published data.
Giant melanin granules in vitiliginous achromia with malignant melanoma.
Histological and ultrastructural examination of normal and perilesional skin of a patient with vitiliginous depigmentation associated with a malignant melanoma revealed the presence of giant melanin granules in keratinocytes and melanocytes. These structures are compared to macromelanosomes which have been observed in numerous pigmentary diseases. The formation and significance of the giant melanin granules is discussed.
[The Reed-Sternberg cell: absence of specific antigens on the surface of B (HBLA) and T (HTLA) lymphocytes].
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Porphyria cutanea tarda-like dermatosis by hemodialysis. Ultrastructural study of exposed skin.
The authors studied by electron microscope, the sun-exposed skin of the back of the hand from three heavily hemodialysed patients with a porphyria cutanea tarda-like bullous skin disease. The vascular impairment, like that of PCT, closely resembles that seen during medicamentous phototoxic processes. The connective tissue is infiltrated by large granulo-filamentous masses and the fibroblasts are secretory in appearance. At the dermal-epidermal junction, the abnormalities are important, with a diffuse infiltration of the upper dermis by a hyalin substance, probably resulting in a collagen degeneration and cellular necrosis. The aetiological factors are uncertain, as no common medicamentous factor appeared in our patients, and as the plasticizers used in the hemodialysis tubes probably played no part.
Origin of Reed-Sternberg cell.
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Vitiliginous achromia with malignant melanoma. Tyrosinase activity and ultrastructural study of achromic and normal skin.
Vitiliginous achromia with malignant melanoma shows some discrepancies with vitiligo. In both achromic and normal skin, four bands A, B, C, D of tyrosinase activity are observed; in vitiligo only bands A and B appear. Ultrastructural findings in achromic skin are similar in both conditions. But in achromia with malignant melanoma, melanocyte abnormalities are also present in normal skin and the role of immunological factors is discussed.
Immunocytological characterization of the mycosis fungoides tumour cell.
The immunocytological identification of the mycosis fungoides cell was carried out on cells extracted from the tumorous nodules of a patient suffering from typical mycosis fungoides. Various techniques, such as E and IgM-EAC rosettes and examination for surface membrane immunoglobulins, were performed on the peripheral blood cells and the tumour cell. Membrane staining with a specific anti-T lymphocyte serum conjugated with peroxidase confirmed the thymodependent origin of the mycosis fungoides cell. However, the immunolabelling (with Fab peroxidase conjugate was found constantly negative.
[An case of acute diffuse seleroderma in an infant].
The authors report a case of diffuse scleroderma in a 15 months old infant. Dermatologic (clinical and pathological) findings are quite typical of the disease. On the other hand, in this case some particularities were observed: the age of the infant (second published case beginning before the age of two); the presence of a durable eosinophilia, the absence of visceral lesions and of biological abnormaliteis (of auto-immune nature specially), the evolution towards athrepsica and death within one year. Thus, because of these particularities, the diagnosis of scleroderma remains questionable and the diagnosis of progeria has been considered. The affection appeared in the course of a hepatitis leaving a hepatic fibrosis without inflammatory signs; no conclusion can be drawn about the relations between the hepatic affection and the fatal dermatologic disease.
[Sjögren-Larsson syndrome].
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Ulstrastructural study of leukodermic skin in Waardenburg-Klein syndrome.
The skin of a patient with Waardenburg syndrome has been studied by electron microscope. In leukodermic skin, there were neither melanocytes nor indeterminate cells; Langerhans cells were normal in number and distribution. On the edge of the lesion, melanocytes were few and appeared degenerated, with abnormal melanosomes; indeterminate cells were observed in suprabasal areas. Healthy skin also showed melanosome abnormalities. These findings are discussed and compared with the characteristics of piebaldism.