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Biomedical subjects

H Perrot

Publications and source records attributed to H Perrot.

At least 37 records · Page 2Linked to original sources
PubMed1999

Linear cutaneous lupus erythematosus in an adult.

We report on a 32-year-old female with a 3-year history of an asymptomatic erythema of the forehead. The lesion had a linear distribution following the lines of Blaschko. Histopathological findings and direct immunofluorescence allowed to establish the diagnosis of cutaneous lupus erythematosus. Treatment with local corticosteroid and antimalarial agents given for 2 months resulted in a complete remission.

Adolescent↗
PubMed1999

[Cutaneous lymphangiectasias acquired after surgical and radiotherapy treatment of breast cancer. Two cases].

We report 2 cases of acquired lymphangiectasias after breast radiosurgical treatment. This well known, rarely reported complication is probably due to a mechanical obstruction of the lymphatic network, and is generally preceded by lymphedema. Our 2 cases, however, did not have previous lymphedema. After a review of the literature, we discuss the role of reparative surgery and other treatment options.

Biopsy↗
PubMed1999

Ulcerated cutaneous epithelioid hemangioendothelioma.

Epithelioid hemangioendothelioma described first by Weiss and Enzinger in 1982 is an uncommon vascular tumor usually involving soft tissue, less frequently the lung and the liver and exceptionally the skin. We herein report a 52-year-old woman who presented an isolated moderately painful persistant ulceration of the concha of her left ear. Histopathological findings showed strands and nests of epithelioid endothelial cells typical of cutaneous epithelioid hemangioendothelioma. Immunohistochemical stainings confirmed the vascular nature of the tumor. Surgical excision by ear amputation was performed. In a review of the literature, to our knowledge, this clinical presentation as ulceration has never previously been reported.

Biopsy, Needle↗
PubMed1998

Validation of antibody-based recognition by piezoelectric transducers through electroacoustic admittance analysis.

The development of immunosensors based on piezoelectric transducers is widely investigated due to their attractive potentialities. The quartz crystal microbalance (QCM) may give a direct response signal which characterizes the binding event between a sensitive layer, immobilized onto the surface transducer, and the analysis to be detected. However, for small biomolecules, such as some antigens, it is quite difficult to obtain an observable signal. This is mainly due to the lack of sensitivity of the commonly used QCM (5 to 10 MHz quartz crystal). Moreover, the mass estimated with the QCM response through the Sauerbrey equation and the mass which can be measured thanks to other analytical techniques, in our case an enzymatic assay, are different: the deposited mass is generally overestimated by the QCM. To validate QCM mass measurements and, therefore antigens recognition, the interactions of acoustic shear waves with a biolayer were investigated during enzyme adsorption onto the microbalance gold electrode or during the antibody/antigen binding. Electroacoustic admittance was measured around the resonance frequency of a 27 MHz quartz resonator in parallel with microbalance measurements. The parameters which characterize the quartz microbalance equivalent circuit were compared with the classical microbalance frequency. The mass overestimation, given by the microbalance, could be explained either by modification of the rheological properties of the sensitive layers and/or by an inadequacy of the assay performed.

Acoustic Impedance Tests↗
PubMed1998

[Melkersson-Rosenthal syndrome].

Melkersson-Rosenthal syndrome is a rare entity and is, in its complete presentation, characterized by the association of recurrent orofacial swelling, peripheral facial palsy and plicated tongue. Clinical diagnosis of incomplete forms, frequently described, is based on major and minor features, currently accepted by numerous clinicians. For most investigators, Miescher's granulomatous macrocheilitis is a monosymptomatic form of the affection. Histopathological findings reveal non-caseating epithelioid cell granulomas, with sometimes perivascular pathognomnic arrangement, which typically shows an obliterant epithelioid lymphangitis. The etiology of the disorder is unknown; a possible association with Crohn's disease has been proposed. Local or general corticosteroids therapy is usually proposed possibly with a cheiloplastic procedure.

Diagnosis, Differential↗
PubMed1998

Generalized granuloma annulare and hepatitis B vaccination.

As hepatitis B vaccination is becoming generalized in Europe, cutaneous adverse events are being more frequently reported in the literature. We report the first case of generalized granuloma annulare following hepatitis B immunization. A 51-year-old woman presented a generalized granuloma annulare one month after the one-year booster injection of the hepatitis B vaccine. The lesions resolved with sulfone therapy. We observed an identical recurrence three weeks after the five-year booster.

Back↗
PubMed1998

[Solitary schwannoma of the balanopreputial sulcus].

INTRODUCTION: Solitary schwannoma is usually located in the head area and the limbs. We report a case of benign solitary schwannoma of the retroglandular sulcus of the glans penis. CASE REPORT: A 64-year-old man had developed over the past year an asymptomatic nodule arising from the retroglandular sulcus of the glans penis. The nodule was removed surgically and histopathological study showed benign schwannoma. There was no association with neurofibromatosis or schwannomatosis. DISCUSSION: Benign solitary schwannoma of the penis is rare. It is most often located on the dorsal shaft of the penis in a young adult. Surgical excision is required. Malignant schwannoma of the penis is very rarely reported.

Aged↗
PubMed1997

[Cutaneous Kaposi disease disclosing acquired immunodeficiency syndrome in a child].

INTRODUCTION: Kaposi's sarcoma associated with acquired immunodeficiency syndrome is uncommon in children and cutaneous localizations are rare. We report a case of pediatric cutaneous Kaposi's sarcoma that revealed a human immunodeficiency virus infection. OBSERVATION: An 8-years-old girl native of the Ivory Coast, with normal statural and psychomotor development, presented cutaneous Kaposi's sarcoma after varicella. The serodiagnosis was positive for type 1 human immunodeficiency virus and CD4 lymphocytes count was 9/mm3. A tonsil localization of Kaposi's sarcoma occurred and bleomycin was a short time effective. A relapse of cutaneous Kaposi's sarcoma with digestive, pulmonary and neurological symptoms was transitorily controlled by the association prednisone-vinblastine-doxorubicin, but death occurred with recurrence of pharyngeal Kaposi's sarcoma. DISCUSSION: The review of literature shows that in pediatric acquired immunodeficiency syndrome, failure to thrive, encephalopathy and opportunistic infections are common. On the other hand, Kaposi's sarcoma is unusual and cutaneous localizations are especially observed when the contamination is postnatal and late. In our case the contamination is presumed perinatal and the human immunodeficiency virus infection was asymptomatic until 8 years old. Kaposi's sarcoma was the cause of the most presenting symptoms and of death, without demonstrated opportunistic infections.

Acquired Immunodeficiency Syndrome↗
PubMed1997

[Persistent erythema multiforme associated with chronic hepatitis C virus infection. Efficacy of interferon alpha].

INTRODUCTION: Persistant erythema multiforme is a rare form of erythema multiforme with subacute typical and atypical lesions that occur during several months. Some cases are associated with chronic viral infection. CASE REPORT: A 23 year-old man, with a past history of intravenous drug addiction and chronic hepatitis C virus infection, presented persistant erythema multiforme for 18 months. The histopathological picture was those of infectious erythema multiforme and the seric total complement level was low. Two courses of alpha-interferon treatment were quickly efficient on cutaneous lesions, and relapse occurred after discontinuation. DISCUSSION: In previously reported cases of persistant erythema multiforme, etiologic complementary investigations are not always specified. However, viral infections should be considered. In cases of chronic infection, hepatitis C may induce immune disorders through persistent antigenic stimulation.

Adult↗
PubMed1996

[Mycobacterium avium-intracellulare subcutaneous abscess after injections of interferon alpha in a patient treated for lymphoma].

INTRODUCTION: Cutaneous involvement with Mycobacterium avium-intracellulare is usually observed in disseminated disease but cutaneous infection alone without bacteraemia is uncommon. CASE REPORT: We report a case of Mycobacterium avium-intracellulare subcutaneous abscess of the thigh in a 32-year-old woman with lymphoma. The lesion was treated with drainage, excision and chemotherapeutic agents. Inoculation was probably secondary to alpha interferon injections performed during one year. DISCUSSION: The review of the literature shows that isolated Mycobacterium avium-intracellulare skin infections are rare, probably induced by traumatic percutaneous inoculation, frequently in immunocompromised patients. The pro-infectious effect of interferon alpha is considered. Treatment is unsatisfactory and surgical excision is often necessary.

Abscess↗
PubMed1996

[Homozygote erythropoietic protoporphyria associated with porokeratosis].

INTRODUCTION: Erythropoietic protoporphyria was generally assumed to be an autosomal dominant disease with variable penetrance. The determination of the ferrochelatase activity and the biological molecular studies have shown that both autosomal dominant and recessive patterns of inheritance are possible. CASE REPORT: Is reported the case of a 17 years-old male patient with erythropoietic protoporphyria and porokeratosis. There are some hepatic biochemical abnormalities without cholelithiasia and without pathological change of the liver biopsy. Leucocyte ferrochelatase activity is decreased to 5 p. 100 of the normal mean level. In both the parents, without photosensitivity, the enzyme activity is reduced to 40 p. 100 of the normal values. DISCUSSION: The patients with severe ferrochelatase defect have no more important clinical manifestations than in the usual form of erythropoietic protoporphyria. For clarify the exact mode of inheritance, the determination of the ferrochelatase activity and the identification of the mutations in the patient and his parents are necessary. In our patient the porokeratosis should be in relation with the protoporphyrin induced phototoxic reaction which facilitate the emergence of a mutant cellular clone of epithelial cells.

Adolescent↗
PubMed1996

[Cutaneous lupus erythematosus and buccal aphthosis after hepatitis B vaccination in a 6-year-old child].

INTRODUCTION: Although the hepatitis B vaccination tolerance is generally good, adverse effects, which are specially neurologic and cutaneous, have been observed and some cases of induced diseases with immunological disorders have been reported. CASE REPORT: A 6 year-old boy presented a cutaneous lupus erythematosus and a severe buccal aphthosis following hepatitis B vaccination. There was no clinical or biological symptom of systemic lupus erythematosus nor of Behçet's disease. Under chloroquine therapy, the cutaneous manifestations of lupus erythematosus disappeared quickly and those of buccal aphthosis improved. DISCUSSION: Hepatitis B vaccination side effects are probably in relation with a specific or non specific stimulation of the immune system. In our case, cellular immunity is perhaps involved through the HBs antigen. Considering the rarity of these side effects, an individual predisposition seems very likely.

Antimalarials↗