Search PubMed⌕ Search

Biomedical subjects

H Pehamberger

Publications and source records attributed to H Pehamberger.

At least 127 records · Page 7Linked to original sources
PubMed1981

[Polymorphonuclear chemotaxis and serum autoantibodies in aging (author's transl)].

Age-associated diseases or dysfunctions may be promoted by functional alterations of the immune system. The chemotactic activity of polymorphonuclear leucocytes (PMN), representing an important factor in immune defence mechanisms, was investigated in a group of people with a mean age of 75.9 years. In addition the serum levels of immunoglobulin (Ig)G, (Ig)M and (Ig)A and the presence of auto-antibodies was determined. The chemotactic activity of PMN in aged people was not decreased when compared with the chemotactic activity of PMN in young persons. The serum levels of IgG, IgM and IgA were within normal limits. Antinuclear antibodies were found in titres of up to 160 in sera of 4 out of 20 aged persons.

Aged↗
PubMed1981

Ocular manifestation of temporal arteritis. Immunological studies.

Since immunological mechanisms may be involved in the pathogenesis of temporal arteritis, serum samples of 15 patients with ocular manifestations of temporal arteritis were investigated for the presence of circulating immune compleses (CICs) and antinuclear antibodies (ANAs). In addition, the serum levels of IgG, IgA, IgM, and the complement components C3 and C4 were determined. In none of our patients could CICs be detected. Serum samples of two of the patients were positive for ANA. The values for IgG, IgM, C3, and C4 were within normal limits. Our data indicate that circulating C1q-binding immune complexes and ANAs are not the cause of ocular manifestation of temporal arteritis. This does not exclude the possibility that other forms of circulating immune complexes or the local formation of immune complexes might play a role in the pathogenesis of this disease.

Aged↗
PubMed1981

Effect of BCG on concanavalin A-induced suppressor cell activity and lymphocyte stimulation in stage I melanoma.

Suppressor cell activity was determined in 14 patients with stage I melanoma, treated with or without adjuvant Bacillus Calmette-Guerin (BCG) immunotherapy, and in 27 normal healthy volunteers. An in vitro test system was used in which peripheral blood mononuclear cells when stimulated with concanavalin A (ConA) significantly suppress proliferative responses of fresh autologous mononuclear cells. In addition, lymphocyte stimulation capacity to optimal and suboptimal concentrations of phytohemagglutinin (PHA) was determined in 44 BCG treated or not BCG treated melanoma patients and in 40 normal individuals. ConA induced suppressor cell activity was significantly (p less than 0.02) impaired in BCG treated melanoma patients (21.3 +/- 3.1% suppression) when compared to not BCG treated patients (39.8 +/- 5.6%) or to normals (38.3 +/- 9.3%). Lymphocyte stimulation capacity was depressed in all melanoma patients when suboptimal concentrations of PHA were used but was found to be not significantly altered at optimal concentration of PHA. The present study reveals that BCG immunotherapy impairs ConA induced suppressor cell activity in melanoma patients but does not influence lymphocyte stimulation capacity.

BCG Vaccine↗
PubMed1981

HLA-DR3 in dermatitis herpetiformis.

Twenty-one patients with dermatitis herpetiformis were typed for HLA-ABC and -DR determinants. The incidence of HLA-AI, -B8 and -DR3 antigens was found to be significantly higher (P: = 10(-3), less than 10(-6) and less than 10(-6), respectively) among patients with dermatitis herpetiformis than among the normal population. HLA-DR3 was found in 85.7% of patients, HLA-B8 in 66.7% and HLA-AI in 61.9% only. These results indicate that HLA-DR3 is the antigen primarily associated in dermatitis herpetiformis and the latter antigens (HLA-AI and -B8) are present in increased incidence, probably due to the known linkage disequilibrium of these antigens with HLA-DR3.

Adolescent↗
PubMed1981

[Single dose treatment of primary syphilis with Benzathine penicillin (author's transl)].

Out of 40 male patients with primary syphilis diagnosed microscopically by dark field preparations and by serological tests 20 patients were treated with a single intramuscular injection of 4.8 millions I. U. Benzathine penicillin and 20 patients with a daily intramuscular injection of 1 million I. U. Clemizol penicillin over a period of 21 days. In all patients success of treatment was verified by complete remission of the clinical symptoms and by serological tests over a period of 2 years. Single dose treatment with Benzathine penicillin represents a simple and reliable method of treatment of primary syphilis.

Adolescent↗
PubMed1981

Polymorphonuclear leukocyte chemotaxis in dermatitis herpetiformis.

Polymorphonuclear leukocyte chemotaxis was investigated in 15 patients with dermatitis herpetiformis and was found not to be significantly increased when compared with the polymorphonuclear leukocyte chemotaxis of 15 normal healthy controls. These results indicate that accumulations of polymorphonuclear leukocytes found in the skin of patients with dermatitis herpetiformis are not due to an increased responsiveness of polymorphonuclear leukocytes to a chemotactic factor.

Adult↗
PubMed1981

[Neurotrophic ulcerations in the trigeminal region].

A patient with trigeminal trophic syndrome is presented. Neurotrophic ulcerations developed one year after injection of alcohol into the gasserian ganglion. The importance of the trigeminal trophic syndrome in the differential diagnosis to malignant skin lesions, lupus vulgaris and syphilis is discussed.

Aged↗
PubMed1980

Effect of BCG on monocyte-mediated antibody-dependent cellular cytotoxicity in stage I melanoma.

The functional activity of monocytes in human disease and the role of this particular cell type in host defense is a matter of current interest. Among several assays for monocyte function, an antibody-dependent cellular cytotoxicity microassay is regarded as a convenient test system in which monocytes of a Ficoll-Hypaque-separated mononuclear cell fraction act as effector cells and consequently lyse 51Cr-labeled, antibody-coated human erythrocytes. This assay was applied to a total of 35 individuals: 20 patients with Stage I melanoma and 15 healthy control subjects. All melanoma cases were treated by means of excision of the primary lesions and subsequent regional lymphadenectomy. Ten patients were selected at random and received additional adjuvant BCG immunotherapy for periods of 9.4 +/- 1.7 months. The mean percentage of 51Cr released in melanoma patients not receiving BCG was significantly lower (P less than 0.01%) than that in healthy control subjects. Monocyte numbers, as evaluated by means of nonspecific esterase staining, were not statistically significantly different.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1980

[Treatment of hyperkeratotic dermatoses with an oral aromatic retinoid (Ro 10-9359)].

Treatment with an oral aromatic all-trans retinoid (Ro 10-9359) resulted in clearing of the skin lesions in five patients with ichthyosis, four patients with Darier's disease and one patient with linear porokeratosis. No response to treatment was achieved in two patients with disseminated superficial actinic porokeratosis. Known side effects of retinoid treatment occurred in all patients in different intensity but disappeared when treatment was discontinued. Due to side effects (pruritus) treatment had to be discontinued only in one patient with Darier's disease and preexisting diabetes.

Administration, Oral↗
PubMed1980

Increased monocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) in Hodgkin's disease.

Monocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) was tested in 23 patients with histologically proven Hodgkin's disease and 29 healthy normal controls. Seven patients presented with active and 16 with inactive disease. The lytic capacity of the individual monocytes was significantly (P < 0.02) higher in patients with Hodgkin's disease than in normals. However, no significant difference was found between the numbers of monocytes in both groups of individuals, as determined by non-specific esterase staining. No correlation was found between the lytic capacity of monocytes and the activity of the disease.

Adolescent↗
PubMed1980

[Antinuclear antibodies (ANA) in inflammatory eye diseases].

The occurrence of antinuclear antibodies was investigated in patients with chronic open-angle glaucoma, senile cataract and retinal detachment, using the indirect immunofluorescence technique. The values obtained were the same as those for a normal population. Additionally, the presence and titer levels of ANA were tested in patients with endogenous uveitis, papillitis and optic neuritis. Our results suggest that ANA do not occur more frequently in these conditions.

Antibodies, Antinuclear↗
PubMed1980

Bullous pemphigoid, herpes gestationis and linear dermatitis herpetiformis: circulating anti-basement membrane zone antibodies; in vitro studies.

It is well established that suprabasal acantholysis can be produced in tissue culture of normal human skin in the presence of pemphigus IgG autoantibody. In this study, bullous pemphigoid, herpes gestationis and linear dermatitis herpetiformis anti-basement membrane zone antibodies failed to produce dermoepidermal separation in a tissue culture model in spite of the presence of complement. The binding of the antibodies was demonstrated by immunofluorescence and immunoelectron microscopy; ultrastructurally, identical binding sites of anti-basement membrane zone antibodies could be demonstrated in vitro, as has been observed in vivo previously. Tissue culture is a suitable model for studying the binding sites of circulating anti-basement membrane zone antibodies but the functional activity (blister format;on) of these antibodies cannot be assessed thereby.

Acantholysis↗
PubMed1980

Effect of PUVA treatment on the locomotion of polymorphonuclear leukocytes and mononuclear cells in psoriasis.

Polymorphonuclear leukocyte (PMN) and mononuclear cell (MNC) locomotion was investigated in patients with psoriasis vulgaris before and after treatment with oral photochemotherapy (PUVA) and was found to be significantly increased (PMN: p < 0.001; MNC: p < 0.002) when compared to healthy controls. No significant difference was observed in the locomotion of PMN or MNC before and after PUVA treatment. These results indicate that PMN and MNC locomotion is increased in psoriasis vulgaris and remains unaltered by PUVA treatment.

Adult↗
PubMed1980

Ultrastructural and immunological findings in Graves' disease with pretibial myxedema.

This is a report on a 67-year-old female patient with Graves' disease and extensive pretibial myxedema. Linear IgM deposits were observed in the basement membrane zone by direct immunofluorescence. These deposits were found, by immunoelectron microscopy, to be haphazardly distributed in the uppermost dermis without any correlation to preexisting structures. An amorphous material that coated not only the surface of fibroblasts and collagen bundles but was also present within the dilated endoplasmic reticulum of the fibroblasts was the predominating pathological finding at the ultrastructural level. Mast cells were morphologically normal. These results support previous in vivo and recent in vitro findings indicating that the fibroblast plays a major role in the pathogenesis of pretibial myxedema.

Aged↗
PubMed1980

Treatment with an oral aromatic retinoid in linear porokeratosis.

Linear porokeratosis is a rare variant of porokeratosis of Mibelli and usually occurs in childhood. A 15-year-old boy is presented with typical clinical lesions of linear porokeratosis on the extensor surface of the right arm exhibiting the classical histopathologic criteria of the disease. Treatment with an oral aromatic retinoid resulted in a remission of the lesion.

Administration, Oral↗
PubMed1980

[Herpes gestationis (author's transl)].

Herpes gestationis is a rare blistering disease of pregnancy and the puerperium which is difficult to differentiate from other bullous eruptions of pregnancy by clinical and histopathological criteria only. Caracteristic immunopathological features permit the exact classification of this disease. This is a report on three typical cases of herpes gestationis. The clinical, histopathological and immunopathological findings of the disease as well as treatment and maternal and fetal risks are discussed.

Female↗
PubMed1979

[Mycosis fungoides bullosa--a case report (author's transl)].

An extremely rare variant of mycosis fungoides, presenting with bullous lesions, is reported. Histopathological examination of the skin revealed subepidermal blister formation, a diffuse mononuclear infiltrate in the uppermost parts of the dermis and the characteristic intraepithelial Pautrier microabscesses. Lutzner cells were found at the ultrastructural level. The mechanism of blister formation in mycosis fungoides is outlined.

Aged↗