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Biomedical subjects

H Parkinson

Publications and source records attributed to H Parkinson.

5 recordsLinked to original sources
PubMed2001

The EMBL nucleotide sequence database.

The EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl/) is maintained at the European Bioinformatics Institute (EBI) in an international collaboration with the DNA Data Bank of Japan (DDBJ) and GenBank at the NCBI (USA). Data is exchanged amongst the collaborating databases on a daily basis. The major contributors to the EMBL database are individual authors and genome project groups. Webin is the preferred web-based submission system for individual submitters, whilst automatic procedures allow incorporation of sequence data from large-scale genome sequencing centres and from the European Patent Office (EPO). Database releases are produced quarterly. Network services allow free access to the most up-to-date data collection via ftp, email and World Wide Web interfaces. EBI's Sequence Retrieval System (SRS), a network browser for databanks in molecular biology, integrates and links the main nucleotide and protein databases plus many specialized databases. For sequence similarity searching a variety of tools (e.g. Blitz, Fasta, BLAST) are available which allow external users to compare their own sequences against the latest data in the EMBL Nucleotide Sequence Database and SWISS-PROT.

Computational Biology↗
PubMed1998

Polytetrafluoroethylene femorodistal grafts: can the use of a vein collar offer patients a reasonable chance of success?

The growing number of patients with critical ischemia who lack a suitable autogenous vein for grafting pose a particular problem for the vascular team. In such patients the use of a polytetrafluoroethylene graft with a distal anastomotic vein cuff or patch has been advocated as an alternative to primary amputation. The use of such adjunctive techniques is reviewed through a 3-year retrospective study of 50 patients under the care of one surgeon. Data analyzed include patient demographics, risk factors, and presenting symptoms. All patients were included in a Duplex graft surveillance program. The cumulative patency rates at 1 and 2 years were 56% and 55%, respectively, with limb salvage rates of 85% and 80%. The data support a reconstructive approach to maintain the quality of the patient's life.

Aged↗
PubMed1997

Natural variation in a Drosophila clock gene and temperature compensation.

The threonine-glycine (Thr-Gly) encoding repeat within the clock gene period of Drosophila melanogaster is polymorphic in length. The two major variants (Thr-Gly)17 and (Thr-Gly)20 are distributed as a highly significant latitudinal cline in Europe and North Africa. Thr-Gly length variation from both wild-caught and transgenic individuals is related to the flies' ability to maintain a circadian period at different temperatures. This phenomenon provides a selective explanation for the geographical distribution of Thr-Gly lengths and gives a rare glimpse of the interplay between molecular polymorphism, behavior, population biology, and natural selection.

Alleles↗