1,4,4-trimethyl-9-phenyl-8-oxa-9-aza-bicyclo
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Journal Article↗
Biomedical subjects
H Pardo
Publications and source records attributed to H Pardo.
[1,3-Bis(diphenylphosphino)propane]trichlorooxorhenium(V).
Trichlorooxo[1,3-propanediylbis(diphenylphosphine)-P,P ']rhenium(V), [ReCl(3)O(C(27)H(26)P(2))], crystallizes with four formula units per unit cell. The crystal structure consists of neutral complexes of [ReOCl(3)(dppp)] [dppp is 1,3-bis(diphenylphosphino)propane] packed by H.pi-ring interactions. The Re atom is octahedrally coordinated to the oxo anion, three Cl atoms and two P atoms from the dppp ligand. The six-membered ring formed by the bidentate dppp ligand and the rhenium metal centre is in a chair conformation. The title compound is an intermediate in the synthesis of bis(dppp) complexes of rhenium.
Crystallography, X-Ray↗
Two absorption furosemide prodrugs.
The structures of two absorption furosemide prodrugs, hexanoyloxymethyl 4-chloro-N-furfuryl-5-sulfamoyl-anthranilate (C19H23CIN2O7S), (I), and benzoyloxymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate (C20H17CIN2O7S), (II), are described in this paper and compared with furosemide and four other prodrugs. The molecular conformations of both compounds are similar to those of the other prodrugs; the packing and the crystal system are the primary differences. Compound (I) crystallizes in the trigonal space group R3 and compound (II) in the monoclinic space group P2(1)/n. The packing of both structures is stabilized by a three-dimensional hydrogen-bond network.
Crystallography, X-Ray↗
The effects of subanesthetic concentrations of sevoflurane and nitrous oxide, alone and in combination, on analgesia, mood, and psychomotor performance in healthy volunteers.
UNLABELLED: We studied the effects of subanesthetic concentrations of sevoflurane and nitrous oxide, alone and in combination, on analgesia, mood, and psychomotor performance in human volunteers. We hypothesized that nitrous oxide and sevoflurane would produce both opposing and potentiating effects within the same study. Over the course of three sessions, 20 subjects inhaled 0%, 0.2%, or 0.4% end-tidal sevoflurane for a 68-min period that was divided into four 17-min blocks. During either the second or fourth block, 30% end-tidal nitrous oxide was added to the concentration of sevoflurane being inhaled. Pain response, psychomotor performance, and mood were evaluated during the second and fourth blocks. Pain ratings were higher when sevoflurane and nitrous oxide were administered together than when nitrous oxide was administered alone, which indicates that sevoflurane attenuated the analgesic effects of nitrous oxide. Sevoflurane increased self-reported ratings of sleepiness, and the addition of nitrous oxide decreased these ratings. Nitrous oxide potentiated psychomotor impairment that was induced by sevoflurane. The combination of sevoflurane and nitrous oxide produced both opposing and potentiating effects within the same study. The results suggest that nitrous oxide and sevoflurane may act through different neurochemical mechanisms on some end points, such as analgesia and sleepiness. IMPLICATIONS: Healthy volunteers inhaled subanesthetic concentrations of sevoflurane and nitrous oxide. Sevoflurane made nitrous oxide less effective as an analgesic, and nitrous oxide made sevoflurane less effective as a sedative. The two drugs may work at cross purposes on different end points of anesthesia.
Adult↗
[Colposuspension in the treatment of stress urinary incontinence: long-term yield].
Surgery in 227 cases of urinary stress incontinence (USI) associated to other abdominal and/or vaginal pathologies, by means Burch colposuspension, has given a success rate of 90.3% recovery of USI 6.6% improved urinary incontinence grade, an 98.3% recovery rate of the concomitant genital prolapse, in a follow-up period mean of 42 moths. Postoperative complication of the surgical procedure are analized.
Adult↗
[Potter syndrome].
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Abnormalities, Multiple↗
[Fetal maturity tests, resolution of labor and results concerning the newborn infant in 91 cases of intrahepatic cholestasis in pregnancy].
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Apgar Score↗
[Cardiac arrest. Clinical case].
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Adult↗
[Bacteriologic study of aerobes and anaerobes in the vaginal flora of pregnant women and in incomplete septic abortion].
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Abortion, Septic↗
[Use of information in evaluating team work in a peripheral outpatient clinic].
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Ambulatory Care Facilities↗