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Biomedical subjects

H Pardes

Publications and source records attributed to H Pardes.

At least 37 records · Page 2Linked to original sources
PubMed1991

Assessing the past and planning the future to ensure support for biomedical research.

The author notes the current extraordinary excitement and opportunity in biomedical research that, oddly, exist within a context of economic constraint for researchers. Also, there is much negative publicity about biomedical science that threatens efforts to obtain adequate funding and responsible handling of science policy in an era where there is relatively little money available for research. The author reviews past instances of damaging public disunity and squabbles by groups in the biomedical research community and then proposes various policy guidelines and strategies to best ensure adequate research funding in the future. For such policies and guidelines to be effective, he stresses the necessity of efforts to heal the past divisions within the biomedical research community and to present a united position that is clear and understandable to Congress and others.

Financing, Government↗
PubMed1989

Genetics and psychiatry: past discoveries, current dilemmas, and future directions.

Family, twin, and adoption studies have suggested an important role for hereditary factors in the etiology and pathogenesis of several psychiatric disorders. Advances in molecular and statistical genetics may very well reveal the identity of these factors, which may include single genes. Linked markers, critical to the discovery of abnormal genes in several medical conditions, have been reported for Huntington's disease, Alzheimer's disease, bipolar disorder, and schizophrenia. Psychiatric disorders pose particular problems (etiologic heterogeneity, incomplete penetrance, variable expressivity) for genetic research. New practical and ethical questions also arise. Nevertheless, knowledge may emerge that will suggest new approaches to diagnosis, prevention, and treatment.

Diseases in Twins↗
PubMed1986

Neuroscience and psychiatry: marriage or coexistence?

Psychiatry, which has experienced the influence of many thrusts in its history, is currently experiencing the impact of neuroscience. Clinicians view the impact with excitement and with apprehension. The author reviews examples of the excitement of scientific developments related to psychiatry. He traces the coexisting evolution of a more differentiated clinical psychiatry and deals with questions of reconciling neuroscience and behavioral approaches. The author's contention is that neuroscience will strengthen psychiatry and that biological and psychological integration will thus be enhanced.

Attitude of Health Personnel↗
PubMed1986

The clinician-researcher in psychiatry.

As clinical research in psychiatry has grown in importance and promise in the past decade, the need for a growing pool of skilled clinician-researchers has been increasingly recognized. Compared with physicians in other specialties, psychiatrists in academic positions have less training in research and devote less time to it, which is reflected in the growing concentration of research funds from the National Institute of Mental Health in just a few of the strongest medical school departments. To focus attention on the need for developing the role of clinician-researchers, the authors examine four major tasks faced by clinician-researchers and present a developmental perspective on the transition to research.

Career Choice↗
PubMed1984

Haloperidol concentrations elevated in Chinese patients.

After 6 weeks of fixed dose oral haloperidol treatment. Chinese schizophrenic patients (in the People's Republic of China) had 52% higher plasma haloperidol concentrations than U.S. non-Asian schizophrenic patients. Chinese and U.S. patients were matched for sex and body weight. The difference in plasma drug concentrations may explain why Asians are reported to require smaller dosages of neuroleptic drugs than non-Asians, and why they may be more sensitive to neuroleptic-induced side effects. When prescribing haloperidol to persons of Asian ancestry, physicians should consider that higher than expected plasma haloperidol concentrations and an increased sensitivity to haloperidol may occur.

Adult↗