Biomedical subjects
Publications and source records attributed to H Palmtag.
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As no simple test exists to verify objectively a neuromuscular lesion of the detrusor in the clinical practice, pharmacological stimulation of the detrusor with Carbachol was tested. In contrast to other pharmacological tests, the modified Carbachol test never led to false-positive results and is therefore recommended as a basic test in the clinical practice.
In an attempt to localise the site of obstruction in children suffering from functional infravesical obstruction, it was found that primary bladder neck obstruction was rare. Only one boy suffering from prune belly syndrome and three children with megacystis demonstrated primary bladder neck obstruction. All of the others had functional bladder neck obstruction as a secondary phenomenon, following either an antireflux operation or electroresection. Bladder neck hypertrophy was found to be a typical secondary alteration following any kind of reactive detrusor hyperactivity.
We report on a 51-year-old male patient who presented with a renal cell carcinoma of advanced stage including multiple pulmonary metastases. A complete regression of the pulmonary metastases was observed after embolisation of the tumor-bearing kidney with subsequent nephrectomy and progesterone treatment. 27 months after the operation the patient is in excellent health without recurrence of metastases.
Of 510 traumatic renal injuries analyzed for the period 1960-1982, 95 patients demonstrated an injury of grade I-V according to the classification of Küster[11]. 88 patients were treated by surgery, 73 had immediate exploration. 15 patients in whom surgery became necessary after a trial of non operative management demonstrated much more complications than those managed by early operative intervention. Nephrectomy had to be performed in 8 of these 15 patients. The value of early excretory urography, ultrasound and sometimes of CT in the diagnosis of renal injuries is discussed. Arteriography and retrograde pyelography are only useful in very selected cases.
Computed tomography was performed in 125 patients with kidney tumors for pretreatment staging. The accuracy of CT staging was then determined by correlating the CT findings with the pathologic findings (111 patients) or with the angiographic findings (14 patients). Perirenal extension was correctly predicted in 79 per cent of all the patients, lymph node involvement in 87, main renal vein involvement in 91, infiltration of the inferior vena cava in 97 and invasion of neighboring organs in 96 per cent. It is concluded that CT should be the baseline procedure for the assessment of the extent of spread of renal tumors.
Fifty-eight patients with malignant renal tumors were submitted to computed tomography scanning. Fifty patients were operated. In eight patients, the disease was too advanced to allow a surgical treatment. The preoperative classification of stages was made according to the Robson scheme and compared with the results of the postoperative histopathological examination. There were identical results in 82% of all operated patients. An analysis of the individual results (fat tissue infiltration, lymph node metastases, infiltration of adjacent organs or veins) shows that the method is limited by the uncertain estimation of the renal vein as well as of the beginning fat tissue infiltration. The good results should give occasion to adopt the computed tomography scanning of the kidney into the staging catalogue of IUCC. Computed tomography scanning should be the basic examination for preoperative staging of renal tumors.
One hundred and three patients with a suspected space-occupying lesion in the kidney were examined by one or both of the above methods. The findings were compared with the histological (45 cases) or final clinical diagnosis (58 cases). In the group in whom the diagnosis was confirmed at operation or histologically, echography proved correct in 41 patients and computer tomography in 44. The latter method was able to show metastatic deposits in lymph nodes, in the liver, the supra-renals and the other kidney, as well as tumour thrombi in the vena cava in patients with tumours. In the group diagnosed only clinically, where the diagnosis had not been confirmed by operation or biopsy, the striking feature was the inaccuracy of echography in the demonstration of small cysts and the uncertainty in differentiation fluid from solid lesions for the exclusion of tumours.
A urodynamic analysis was performed on 1,300 patients to precise typical psychogenic voiding patterns. Only 2.7% of this selected group showed voiding alterations derived from a psychosis or neurosis. The psychosomatic voiding alterations were to some degree similar to the alterations which were provoked by exogenous or iatrogenic influences. The voiding pattern of young children differs from that of adults when comparing psychosomatic symptoms such as prostatitis or enuresis. Urine retention and megalocystis were characteristic findings of psychotic patients whereas a polyphasic flow pattern, a delay of micturition and increased sacral reflex activity were typical findings of psychosomatic disorders. The denervation supersensitivity test is a reliable test to differentiate neurogenic from psychogenic voiding patterns.
Knowledge of the patho-anatomic variants of the hypernephroid renal carcinoma as well as of its computertomographic correlate facilitates diagnosis and prevents fatal diagnostic errors. Measurements of density by computer tomography, as well as on-target application of contrast medium, are of great importance for arriving at the correct diagnosis.
In the last years the symptom of unstable bladder behaviour has been interpreted with increasing clinical importance, sometimes being regarded as a diagnosis or as a causative factor for different complaints (1, 3-6, 16, 18, 20). The term 'unstable bladder' is still not precisely defined (17). Few investigations on this topic had been done in children, therefore, the urodynamic findings of 216 children were analysed to look for co-findings of bladder instability and, if possible, to demonstrate some causative factors. The investigations revealed that unstable bladder behaviour seems to be a secondary cystometric phenomenon (directly or indirectly induced). The treatment of unstable bladder should be concentrated on the causative disorder rather than on the cystometric symptom
Urodynamic studies were carried out in a 14-year-old boy with Prune Belly Syndrome and terminal renal failure prior and after successful renal transplantation. Increased bladder capacity, nonprovocative detrusor instability and a high compliance were the most characteristic findings during the filling phase of the bladder. During the voiding phase an increased detrusor pressure was demonstrated. Outflow resistance and maximum urinary flow rate were within normal range before and after transplantation. In contrast to the findings before renal transplantation, however, micturition was imbalanced after transplantation (residual urine 100 ml). Urodynamics revealed that the bulging of the posterior urethra, observed in the early voiding phase, was due to a congenital insufficiency of the posterior urethral musculature (megalourethra) and not caused by mechanical obstruction leading to urethral dilatation. It is suggested that detrusor-bladder-neck-dyssynergia is the primary cause of the imbalanced micturition and its consequences (bladder distention, reflux, urinary tract infection, hydronephrosis, pyelonephritis) in patients with Prune Belly Syndrome. The findings of a normal, respectively increased detrusor activity are in contrast to the observations of some authors, describing attenutation and absence of detrusor muscle fibres. The indications and effects of transurethral resection and internal urethrotomy, proposed by some authors, are discussed.
The urodynamic findings of 247 patients with a neurogenic bladder dysfunction were analyzed to evaluate factors which influence the X-ray picture of the bladder neck and urethra. Patients were classified according to the classification of Bors and Commarr, additionally different types of reflex detrusor activity could be differentiated in cases suffering from a supranuclear lesion. As the micturition cystourethrography of female patients with a supranuclear lesion looks similar to the X-ray picture of young girls with a WBNA a second analysis was made to compare the urodynamics of both groups. It is to note that in supranuclear lesions detrusor-sphincter dyssynergia and the type of reflex detrusor activity mainly form the shape of the posterior urethra, neither the duration of the lesion nor the level of spinal cord injury have any influence.
The bladder capacity of patients with a neurogenic bladder disorder was determined. Since the bladder capacity varies according to the type of neurogenic lesion (supranuclear, infranuclear), it was to be determined, whether reflex detrusor activity and duration of the lesion would influence bladder capacity. It was found that in supranuclear lesions s sufficient bladder capacity can be maintained with a balanced micturition, and that spincterotomy does not result in reduced bladder capacity. In infranuclear lesions intermittent catheterization is a good therapeutic method to preserve continence and an intact renal function as well.
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The second case of successful renal transplantation in a patient with "prune belly" syndrome is reported. In spite of early aggressive surgical approach in the management of this disease terminal renal failure frequently ensues. Hemodialysis and renal transplantation have offered new possibilities of prolonging life in these patients. The success of renal transplantation depends on the anatomic and functional state of the lower urinary tract. Pretransplant urologic examination is extremely important for the evaluation of urinary tract abnormalities.
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