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Biomedical subjects

H Palmer

Publications and source records attributed to H Palmer.

At least 37 records · Page 2Linked to original sources
PubMed1988

Platelet-derived growth factor or basic fibroblast growth factor induce anchorage-independent growth of human fibroblasts.

Anchorage-independent growth, i.e., growth in semi-solid medium is considered a marker of cellular transformation of fibroblast cells. Diploid human fibroblasts ordinarily do not exhibit such growth but can grow transiently when medium contains high concentrations of fetal bovine serum. This suggests that some growth factor(s) in serum is responsible for anchorage-independent growth. Much work has been done to characterize the peptide growth factor requirements of various rodent fibroblast cells for anchorage-independent growth; however, the requirements of human fibroblasts are not known. To determine the peptide growth factor requirements of human fibroblasts for anchorage-independent growth, we used medium containing serum that had had its peptide growth factors inactivated. We found that either platelet-derived growth factor (PDGF) or the basic form of fibroblast growth factor (bFGF) induced anchorage-independent growth. Epidermal growth factor (EGF) did not enhance the growth induced by PDGF, or did so only slightly. Transforming growth factor beta (TGF-beta) decreased the growth induced by PDGF. EGF combined with TGF-beta induced colony formation in semi-solid medium at concentrations at which neither growth factor by itself was effective, but the combination was much less effective in stimulating anchorage-independent growth than PDGF or bFGF. This work showed that PDGF, or bFGF, or EGF combined with TGF-beta can stimulate anchorage-independent growth of nontransformed human fibroblasts. The results support the idea that cellular transformation may reduce or eliminate the need for exogenous PDGF or bFGF.

Blood↗
PubMed1987

Tumbling abrasions. Injuries from ricocheting bullets.

Atypical entrance gunshot wounds may be produced by deflected or ricocheting bullets. One special type of atypical entrance wound involves abrasion of the skin at a site that is remote from the point of dermal penetration. These remote abrasions, termed "tumbling abrasions," are produced by bullets that tumble after impact with an intermediate target. Three cases of tumbling abrasions are presented.

Breast↗
PubMed1983

Methodological aspects of examination of 24 hour urinary excretions in outpatients with recurrent urolithiasis.

In 85 recurrent stone formers, 2 consecutive 24 h urinary excretions were subjected to chemical examination for calcium, uric acid, magnesium and creatinine. 23 patients had hypercalciuria (greater than 6 mmol/24 h), 22 hyperuricosuria (greater than 3.5 mmol/24 h) and 5 hypomagnesuria (less than 2.4 mmol/24 h). In 1/3 of the cases, the diagnosis would have been missed if based on only one of the two collections, rather than on the mean values from both. Calcium-restricted diet 3 days before and during the sampling is not recommended. Hydrochloric acid appeared to be useful as a preservative and to prevent calcium and magnesium precipitation. No significant seasonal variations were found. Heating of the urine sample before analysis of uric acid did not influence the result.

Adult↗
PubMed1976

Several unusual cases of child abuse.

All childhood deaths which occurred in New Mexico during 1974 and 1975 were reviewed. Nine fatal instances of abuse were identified representing the entire spectrum of physical abuse: neglect, abuse in a single episode of injury, repetitive abuse, or sexual abuse. Several cases are summarized. These are unusual either in the distribution of pathologic findings or in the problems encountered in court presentation.

Child Abuse↗
PubMed1969

Nurses for nursing.

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Nursing Service, Hospital↗