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Biomedical subjects

H P Dustan

Publications and source records attributed to H P Dustan.

At least 19 recordsLinked to original sources
PubMed1997

Renal arterial disease and hypertension.

Renal artery stenoses can cause hypertension and renal failure. These lesions can be relatively easily diagnosed and most can be successfully treated. Recognizing them is important because relief of stenoses either by angioplasty or surgical revascularization often cures the hypertension and, if renal failure is present, improves or stabilizes excretory function.

Angioplasty↗
PubMed1996

Controlling hypertension. A research success story.

In the past 2 decades, deaths from stroke have decreased by 59% and deaths from heart attack by 53%. An important component of this dramatic change has been the increased use of antihypertensive drugs. This remarkable success resulted from broad-based and diverse research programs supported by the federal government, pharmaceutical companies, voluntary health agencies, and private foundations. It included basic research, drug development programs, epidemiologic studies, health surveys of US citizens, clinical research, and large-scale drug trials. Four of the categories of antihypertensive drugs in wide use--diuretics, beta-blockers, calcium antagonists, and angiotensin-converting enzyme inhibitors--emerged from widely different areas of investigation. In the beginning, the major breakthroughs that led to the development of these drugs were impossible to forecast, and their ultimate applications were impossible to predict. Although decreases in hypertension-related mortality are impressive, enthusiasm must be tempered because the mechanisms of hypertension are still incompletely understood and prevention is not yet possible. Continued research is needed to extend these advances.

Antihypertensive Agents↗
PubMed1996

Gender differences in hypertension.

The evidence we have for the US, Australia and Korea indicates that men have slightly higher pressures than women and slightly greater prevalence of hypertension. In the US this sex difference is reversed at about age 70 and persists throughout the rest of the lifespan. How much these gender differences affect gender differences in cardiovascular disease manifestations is not clear, but remains an intriguing possibility.

Adolescent↗
PubMed1995

Does keloid pathogenesis hold the key to understanding black/white differences in hypertension severity?

Repeated national surveys have shown that in the United States hypertension is more common and more severe in the black than in the white population. This discussion presents the hypothesis that the racial difference in hypertension severity is because of differences in growth factors (cytokines) affecting vascular smooth muscle cell growth. This hypothesis is derived from studies of keloids, which occur almost exclusively in blacks. Keloid fibroblasts in culture have growth characteristics that differ substantially from those of normal skin. Furthermore, there is evidence that peripheral blood mononuclear cells from patients with keloids produce different amounts of cytokines than do similar preparations from the blood of individuals without keloids. A growing body of evidence indicates that growth factors play a pivotal role in the pathogenesis of atherosclerosis, in experimental forms of hypertension, and in various renal diseases; it may be that they function in clinical hypertension as well.

Adolescent↗
PubMed1992

Cardiovascular consequences of obesity.

Obesity is common in populations that are overnourished and can become a significant public health problem. Obesity predisposes to non-insulin dependent diabetes mellitus, hypertension, dyslipidemia, cholelithiasis, some malignancies and osteoarthritis. These consequences that most directly affect the cardiovascular system are dyslipidemia and hypertension. Nations in which obesity is rare should learn from the experience of the countries where it is prevalent, that prevention of obesity is a public health measure rather than weight reduction.

Coronary Disease↗