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Biomedical subjects

H Ozen

Publications and source records attributed to H Ozen.

At least 127 records · Page 7Linked to original sources
PubMed1993

Incidentally discovered solid renal masses: what are they?

In 36 of 99 consecutive patients operated on for the presumptive diagnosis of renal carcinoma the tumour was discovered accidentally during investigations for a variety of complaints. CT and ultrasound scans were responsible for discovery of the tumour in 24 of the 36 patients. Renal carcinoma accounted for 92% of incidentally discovered solid renal masses. Of 33 incidentally diagnosed renal carcinomas 27 were stage 1. An incidentally discovered solid renal mass should be regarded as a low stage renal carcinoma until proven otherwise.

Aged↗
PubMed1993

Should radical nephrectomy include ipsilateral adrenalectomy?

We reevaluated 46 patients with histopathologically proven stage A and B renal cell carcinoma, who underwent radical nephrectomy for the presence of ipsilateral adrenal gland in the surgical specimens. It turned out that 23 specimens included ipsilateral adrenals. Two patients without adrenalectomy relapsed locally, whereas no local recurrence was noted in patients whose adrenals were removed. Three years' disease-free survival rates (DFS) for patients with and without adrenalectomy were 100% and 78%, respectively. Although no statistical difference was found in terms of DFS between patients with and without adrenalectomy, we suggest the removal of the ipsilateral adrenal gland if technically feasible.

Adrenal Gland Neoplasms↗
PubMed1993

Methotrexate, vinblastine, adriamycin and cisplatin (MVAC) chemotherapy for the treatment of advanced bladder carcinoma.

Thirteen patients with advanced urothelial transitional cell carcinoma were treated with methotrexate, vinblastine, adriamycin and cisplatin combination. No complete remissions were achieved in patients with disseminated diseases; only three out of five patients (60%) with localized tumours in the bladder or perivesical space responded completely. Localized tumour recurrences in the bladder occurred in two of three complete responders at the ninth and tenth months after chemotherapy. Four patients died during or after chemotherapy: one from disease progression and the remainder from chemotherapy complications. Authors conclude that, although 23% complete and 30.8% partial remissions were achieved with the MVAC chemotherapy, strict toxicity monitoring and careful selection of patients are essential because of its non-negligible complications.

Aged↗
PubMed1992

Bladder cancer.

In the search for sensitive and specific tumor markers for bladder carcinoma, expression of various oncogenes and gene products (such as c-erb B-2, p53) and epidermal growth factor receptor merits particular attention. Although the results are not yet conclusive, important predictive markers are about to emerge from ongoing studies in this field. Bacillus Calmette-Guerrin treatment in superficial bladder cancer is probably the most successful immunotherapy in humans. But there is still a large knowledge deficit in the issues of optimal dose schedule and mechanisms of action. Although promising results of neoadjuvant chemotherapy in patients with invasive bladder cancers are reported, we must be cautious about changing our conventional approach until the results of large scale, controlled, randomized studies evaluating the survival are published.

Actuarial Analysis↗
PubMed1992

[Effects of prostatic massage on serum levels of prostatic acid phosphatase and specific antigen].

We studied the influence of prostatic massage on the seric levels of acid prostatic phosphatase (PAP) and prostatic specific antigen (PSA) before and 1, 24 and 48 h after the examination. Three groups of patients were studied: 13 patients with prostatic benign hypertrophy (PBH), six patients with metastatic prostate carcinoma and 10 control patients (urinary lithiasis). We observed a significant elevation of both seric markers 1 h after prostatic massage in the PBH and control groups. In both groups, seric marker levels returned to normal values within 24 h with PAP and 48 h with PSA. We recommend to assay serum PSA and PAP with an interval of at least 48 h after rectal digital examination.

Acid Phosphatase↗
PubMed1991

Dynamic cavernosography in the evaluation of impotence.

Dynamic cavernosography before and after papaverine injection into the corpus cavernosum of 6 sexually normal volunteers and 44 impotent patients was performed with digital subtracting angiography technique. The average infusion rates in 26 patients with venous leakage were 325.5 ml/min for induction of erection and 161 ml/min for maintenance. The results for the remaining 18 impotent patients without venous leakage were 128.8 ml/min for induction and 56.9 ml/min for induction and 58.3 ml/min for maintenance. After papaverine injection the average infusion rates decreased to 131 ml/min (induction) and 59 ml/min (maintenance) in patients with venous leakage, 38.4 ml/min and 14.6 ml/min in the impotent patients without venous leakage and 35 ml/min and 14.1 ml/min in the control group, respectively. It was also noticed that in the control group filling of the superficial and deep veins may occur during the flaccid phase which disappeared with induced erection. Therefore we suggest intracavernous papaverine injection with dynamic cavernosography. The digital subtracting technique eliminates unnecessary images, providing a more accurate diagnosis of venous incompetence.

Adult↗
PubMed1991

Screening of asymptomatic siblings of patients with vesicoureteral reflux.

Familial trait in vesicoureteral reflux (VUR) has been revealed in many studies. This paper reports on 36 siblings of 25 patients operated for vesicoureteral reflux at our Department. Siblings aged 2 to 21 years were evaluated by urine examination, urine culture and voiding cystourethrogram (VCU) for VUR. All of the siblings were asymptomatic and VUR was found in only 4 of them (11%), unilateral in 3 cases and bilateral in one case. It is concluded that evaluation of siblings for VUR will be suitable for revealing the presence of urinary infection, and assessing them by VCU at the time they are first seen.

Adolescent↗
PubMed1991

Serum ferritin: a tumor marker for renal cell carcinoma.

Serum ferritin levels in 32 patients with renal cell carcinoma were evaluated preoperatively and postoperatively. Serum ferritin concentration was significantly higher in renal cell carcinoma patients compared to controls (259.10 versus 61.30 ng./ml., p less than 0.001). Furthermore, there was a steady and statistically significant increase in serum ferritin levels with advancing disease stage, as well as a significant decrease in serum ferritin levels after nephrectomy for stages 1 and 2 disease. The intracellular content of ferritin as estimated by polyclonal antibody was dramatically increased in renal cancer tissue compared to normal parenchyma. Although serum ferritin regulation is complex and only partly understood, the present study suggests that serum ferritin may be a useful tumor marker for renal cell carcinoma.

Adult↗
PubMed1991

Prognostic factors and therapy for superficial and invasive bladder cancer.

Although most of the transitional cell carcinomas are superficial at presentation and pose little problem as far as survival is concerned, predicting the ones that will recur and, more importantly, recur as invasive tumors, is crucial. Determination of serum and urine human chorionic gonadotropin-beta levels and epidermal growth factor receptor analysis are promising in this respect. Intravesical bacillus Calmette-Guérin, which is widely used to prevent further recurrences and to treat carcinoma in situ, augments the host's immune status, probably by increasing interleukin-2 and tumor necrosis factor levels. Intravesical interferon seems to be a promising agent, especially against carcinoma in situ, and has exceptionally few side effects. Multidrug chemotherapy regimens such as methotrexate, vinblastine, doxorubicin, and cisplatin, or cisplatin, methotrexate, and vinblastine have achieved 30% to 40% objective complete remission rates in patients with metastatic bladder cancer. These regimens are also used in a neoadjuvant setting with or without irradiation in the hope that more patients will be spared cystectomy and enjoy similar if not better survival. At the same time, continent diversions and nerve-sparing cystoprostatectomy open a new era in the treatment of invasive bladder cancer by improving the quality of life after cystectomy. Although important progress has been made, there is still room for research and clinical controlled studies to achieve higher rates of response, prolonged disease-free survival, and perhaps even improved rates of cure.

Combined Modality Therapy↗
PubMed1990

Bilateral perineal ectopic testes.

Perineal testicular ectopia is seen very rarely, bilaterality is even more scarce and three cases have been reported in the literature. Here we present the fourth case with bilateral perineal ectopic testes.

Child, Preschool↗
PubMed1990

Treatment of testicular hydrocele with tetracycline sclerotherapy.

Fifteen patients with primary hydrocele of the testis were treated by aspiration and injection of tetracycline. Only 5 patients (33.3%) were cured by a single injection of tetracycline. Furthermore, 46.6% of our patients experienced severe scrotal pain, three of whom required open surgery. We do not recommend single injection tetracycline therapy, and further injections were not performed due to severe side effects.

Adult↗
PubMed1989

Histopathological changes in adult cryptorchid testes.

The histological specimens of 73 patients who presented with undescended testes after puberty were re-evaluated. None of the specimens revealed carcinoma in situ but in the specimens of 5 patients severe atypia was detected. None of the patients, including 5 with severe atypia, has shown any evidence of invasive testicular tumour during follow-up.

Adolescent↗
PubMed1988

Significance of scrotal violation in the prognosis of patients with testicular tumours.

Thirty-five patients with testicular cancer who had scrotal contamination during or prior to their primary treatment were compared with 70 patients who had undergone radical inguinal orchiectomy. The survival curves, disease-free intervals and 2-year survival rates of the two groups did not differ significantly and we do not advocate additional aggressive surgical treatment to the scrotum and superficial inguinal lymph nodes in these patients.

Dysgerminoma↗
PubMed1985

Varicocele and antisperm antibodies.

Semen analysis and immunofluorescent antisperm antibodies were tested in 65 patients with varicocele. The mean sperm count and motility values in our study were 36.8 +/- 2.9 million per ml and 38.4 +/- 2.5 per cent, respectively. Both parameters were found not to differ significantly in three grades of varicocele. Immunofluorescent antisperm antibodies were detected in 24.6 per cent of the cases. A significant correlation was demonstrated between the presence of the antibodies and genital infection.

Adult↗
PubMed1984

The advantages of bilateral simultaneous stone removal from the upper urinary tract.

An anterior transperitoneal approach was used to remove the stones from both kidneys and/or ureters simultaneously in 18 patients. The morbidity of this type of surgery in our study was very low and there were no surgical difficulties in exposing the intrarenal structures. Furthermore, especially in secondary cases, this approach was easier and more time-saving than the classical flank approach. We recommend its use at least in selected groups of patients in whom peritoneal gross contamination is not expected.

Adolescent↗