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Biomedical subjects

H Oxorn

Publications and source records attributed to H Oxorn.

10 recordsLinked to original sources
PubMed1987

Endometrial prostaglandins and menorrhagia: influence of a prostaglandin synthetase inhibitor in vivo.

Prostaglandin levels in the human endometrium were determined on day 2 of the menstrual cycle in eumenorrheic subjects and in patients with menorrhagia, dysmenorrhea, or both. Menorrhagic subjects had significantly higher levels of endometrial prostaglandins of the E and F series when compared with eumenorrheics. Prostaglandin E levels were markedly higher than prostaglandin F. In 10 menorrhagic subjects who completed a double-blind clinical study on the effectiveness of mefenamic acid in lowering menstrual blood loss, 9 exhibited statistically significant reduction in endometrial prostaglandin levels. A decrease in menstrual blood loss was also noted during mefenamic acid treatment in these patients. These findings are consistent with the concept that abnormally high uterine prostaglandin levels may be an important etiologic factor in menorrhagia and support the notion that one of the mechanisms of action of nonsteroidal anti-inflammatory agents in the treatment of this menstrual disorder is inhibition of endometrial prostaglandin production.

Adult↗
PubMed1981

Pyometra.

Pyometra is a potentially lethal disease. Eighteen cases, all but one in postmenopausal women, were diagnosed at the Ottawa General and Ottawa Civic hospitals between 1974 and 1978 inclusive. A review of this series and of the literature demonstrates that a large proportion of cases (72% in this series) are associated with or follow radiotherapy for a malignant disease of the uterus and that anaerobic bacteria are frequently isolated from the uterine cavity (in 56% of the patients in this series). Because pyometra is potentially lethal (one patient in our series died) it should be considered as an abscess and treated promptly and vigorously by evacuation and continued drainage of the uterine cavity. Curettage of the cavity and the endocervical canal after dilatation is essential to rule out associated malignant disease as well as to debride the necrotic tissue. Antibiotics effective against aerobic and anaerobic bacteria should be given to all patients with signs of systemic infection. Once the infection is controlled, the underlying problem can be treated.

Adult↗
PubMed1981

Postradiation ureteral obstruction: a reappraisal.

Thirty-four patients who received radiation therapy for carcinoma of the cervix developed hydronephrosis. Twelve of 34 (35%) had no evidence of pelvic malignancy, and the obstruction was caused by periureteral fibrosis. The incidence of obstructive uropathy due to periureteral fibrosis not associated with recurrent tumor increased when the obstructing lesion was unilateral, the clinical staging of the cervical carcinoma prior to therapy was Stage IB or Stage II rather than Stage III or Stage IV, and the obstructing lesion appeared 2 or more years after the completion of radiation therapy. The appearance of hydronephrosis in association with ipsilateral leg edema, and sciatic pain these patients strongly suggest a recurrent tumor. The diagnosis of periureteral fibrosis should be considered in all patients who develop obstruction of the urinary tract after radiation therapy for carcinoma of the cervix. Laparotomy is indicated if all other methods of investigation fail to confirm the presence of a malignant lesion.

Edema↗
PubMed1975

Appendicitis in pregnancy.

Over a 9-year period at one hospital 25 appendectomies were performed during pregnancy. In 20 cases the appendix was acutely inflamed. All mothers survived. Two women aborted and two went into premature labour. One of the premature infants survived. The fetal loss associated with acute appendicitis was 15%. Early diagnosis and operation is essential.

Abortion, Spontaneous↗
PubMed1973

Torsion of the gravid uterus.

A case is reported of a 180 degrees levorotation of the gravid uterus with successful outcome for mother and child. Delivery was by cesarean section.Only 108 cases of rotation of the gravid uterus have been reported in the world's literature. A uterine tumour was associated in almost one third of cases. The condition usually presents as an acute abdomen. Complications include uterine rupture and pulmonary embolism. Treatment is by laparotomy and de-torsion, with cesarean section if at term or near term.

Abdomen, Acute↗
PubMed1973

Familial incidence of ovarian dermoid cysts.

A mother and two daughters, each with bilateral ovarian dermoid cysts, are reported and the literature on the familial incidence of dermoid cysts is reviewed. The incidence and description of teratomas are discussed and theories of origin for teratomas are presented.

Adult↗