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Biomedical subjects

H Ono

Publications and source records attributed to H Ono.

At least 631 records · Page 35Linked to original sources
PubMed1982

Effect of an antianginal drug, perhexiline, on myocardial oxygen consumption in anesthetized open-chest dogs compared with verapamil and glyceryl trinitrate.

A pharmacological study on myocardial oxygen consumption was carried out in open-chest dogs using an arterio-venous oxygen difference analyzer. The continuous monitoring of the oxygen difference showed that the peak changes in coronary blood flow did not coincide with the greatest change in myocardial oxygen consumption. Perhexiline, 0.3-3 mg/kg intravenously, increased coronary blood flow and decreased myocardial oxygen consumption, dose-dependently. Perhexiline decreased aortic and systemic blood pressures and left ventricular work except for lower doses of perhexiline which slightly increased cardiac output and ventricular work. Over-all mechanical efficiency of the left ventricle was increased with perhexiline, while the efficiency was decreased around the peak effect of larger doses of the drug on systemic blood pressure and coronary artery. Verapamil, 0.03-0.3 mg/kg, showed essentially the same effects as perhexiline with ten-fold potency superior to perhexiline. Glyceryl trinitrate showed inconsistent effects on coronary flow and myocardial oxygen consumption, and it decreased cardiac work and mechanical efficiency of the left ventricle.

Animals↗
PubMed1982

Different effects of captopril on blood pressure in the acute and chronic two-kidney Goldblatt hypertensive dogs.

Captopril was administered to acute (8 to 14 days after unilateral renal artery constriction) and chronic (71 to 127 days after the constriction) two-kidney Goldblatt hypertensive dogs, and to normotensive ones for 21 days (oral administration of 10, 20 and 40 mg/kg/day, consecutively each 7-day period). The decrease of arterial blood pressure was remarkable in hypertensive animals with high plasma renin activity, but not in the normotensive animals. In the acute stage of hypertension, the antihypertensive effect of captopril was dose-dependent and persistent even after its cessation. In the chronic stage of hypertension, blood pressure also decreased, but the response was not dose-dependent and did not continue after cessation. Plasma renin activity rose in both hypertensive and normotensive animals during the treatment with captopril. There were no significant changes in heart rate, daily urinary volume, sodium balance, and renal clearances of sodium (CNa), potassium (CK), chloride (CCl) and creatinine (CCr). Circulating blood volume was also not altered. These results indicate that the main mechanism of antihypertensive effect of captopril in two-kidney Goldblatt hypertensive dogs is an inhibition of the angiotensin converting enzyme. In addition, the different effects in the acute and chronic hypertensive dogs suggest that some differences exist in the mechanism(s) of maintaining blood pressure between the two stages of two-kidney Goldblatt hypertension in dogs.

Administration, Oral↗
PubMed1982

Deterioration of spinal reflex in beagles orally ingesting clioquinol.

Spinal reflex and neuromuscular functions were investigated in the beagles ingesting clioquinol over a long period. The twitch tension, the refractory period, the summation of contraction and the discharge of the muscle spindles of the gastrocnemius muscle were not significantly damaged in the treated beagles, whereas the response with long latency of the spinal reflex disappeared completely during the administration not in the control but in the treated dogs. The meanings of disappearance of the spinal reflex in the treated dogs are discussed in relation to the degenerative change in the fasciculus gracilis at the cervical level of the spinal cord.

Administration, Oral↗
PubMed1982

[Simple metastasis of hepatocellular carcinoma to the skull--a case report].

The patient, a 53-year-old man, was admitted to the Department of Neurosurgery, Nagasaki University Hospital in August 1979, because of a painful tumor in the lt-parieto-occipital region. Physical examination on admission revealed a fist-sized tumor in the lt-parieto-occipital region. The liver edge was palpable at two finger breadths beneath the right costal margin, but the liver itself was not palpable as a mass. Liver function was almost good except for GOT and ChE. Plain craniography showed an osteolytic change of about 10 cm X 10 cm in size without marginal hyperostosis and spicular formation. Bilateral external carotid angiography demonstrated a hypervascular mass, which was fed by the bilateral superficial temporal arteries and occipital arteries. CT scan also demonstrated a fist-sized tumor originating from the diploë with destruction of the skull bone. Tumor was strongly enhanced. A radical removal of tumor was performed. Tumor was solid with profuse bleeding and adhered tightly to the dura and the skin. The postoperative course was uneventful and postoperative CT scan demonstrated complete removal of the tumor. Histological diagnosis was hepatocellular carcinoma and the skull tumor was considered to be metastatic. CT scan of the liver showed a circumscribed low density area with ring enhancement at the posterior ventral site. As no metastasis was found in other organ except the skull, so primary lesion was radically removed at the Second Department of Surgery. The incidence of metastasis to the bone in hepatocellular carcinoma in autopsy studies has been considered rarely approximately from 4 to 14%. Moreover, the common sites of skeletal metastasis are the vertebral column, the ribs, the long bones and so on. Metastases to the skull bone was exceptionally rare and all cases hitherto reported had multiple metastases in other organ(s) and no literature was found about the distant metastasis to the skull bone only.

Carcinoma, Hepatocellular↗
PubMed1982

[Surgical technique and anatomical point of carotid endarterectomy].

Many different techniques have been utilized for carotid endarterectomy (CEA). The method demonstrated here employed a minor but significant alteration especially in the techniques for dissection and the removal of the atheromatous plaque. This was to cope with the Japanese atheromatous plaque which is, according to the author's study, characterized by the less marked atheroma ends both in the smaller internal carotid and common carotid artery with high bifurcation. In addition, the more fibrous nature of the plaque requires a technique to find and develop the adequate layer for the CEA. These techniques were explained together with related anatomies. Anatomical structures included in this article are summarized in Table 1.

Carotid Arteries↗
PubMed1981

Changes of electroretinogram and neurochemical aspects of GABAergic neurons of retina after intraocular injection of kainic acid in rats.

The effect of kainic acid (KA) on both electroretinogram (ERG) readings and neurochemical properties of the retina was investigated in rats with emphasis placed upon examination of the events that occur immediately following KA treatment. KA was injected into the eyes of rats with doses of 50 and 200 nmol. One hour after injection, histological alterations became evident. Swelling was observed in the inner and outer plexiform layers. Certain ganglion cells and cells of the inner nuclear layers exhibited pyknotic nuclei. Most of the ganglion cells appeared to have degenerated 48 h following injection, and the form of the outer plexiform layer was incomplete. The amplitude of the b-waves of the ERG decreased 2 h following injection and never recovered. The amplitude of the a-waves was unaffected by KA. The gamma-aminobutyric acid content in the eyecups began to decrease within 1 h and fell to approximately 20% of its original level 24 h following injection. The taurine content in the eyecups was unaffected by KA. The activity of glutamic acid decarboxylase remained unaffected for 2 h after injection, but was reduced to approximately 40% of its original activity by 24 h after injection. A possible explanation for the mechanism by which KA effects degenerative changes in the rat retina is that KA induces release of neurotransmitters through stimulation of neurons, and degeneration in the soma follows.

Animals↗
PubMed1981

Experimental studies on cadaver pancreas preserved by perfusion.

pancreatic transplantation is the most effective therapy of advanced diabetes mellitus. However, the problem is whether the cadaver pancreas can be used as a donor, because the living pancreas cannot be used as a donor from an anatomical standpoint. In case of the cadaver pancreas another problem is coming up that the pancreas proceeds to rapid autolysis. So, brain death is recommended as the most available condition for this transplantation. In this study we investigated the viability of the cadaver pancreas from decapitated rats preserved by the cold perfusion method. The results obtained were as follows: 1) The perfusing time affected the ratio of degenerative islets/normal islets. A large number of degenerative islets appeared with long perfusion time. 2) The cold (4 degrees C) perfusion method could preserve cadaver pancreas for 5 hours. 3) Insulin-secretion of cadaver pancreatic islets preserved for 5 hours under cold perfusion was 60% or more of that of normal pancreatic islets. 4) Three hundred islets from cadaver pancreas preserved for 5 hours under cold perfusion were transplanted into the portal vein of streptozotocin-induced diabetic rats. Four of these 11 rats recovered from diabetic state and maintained the non-diabetic state for 20 weeks after transplantation.

Animals↗