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Biomedical subjects

H Olbing

Publications and source records attributed to H Olbing.

At least 73 records · Page 4Linked to original sources
PubMed1980

[Clinico-pathological data in infants with different types of nephrotic syndrome (author's transl)].

Case reports including light- and electron microscopy about 4 children with infantile nephrotic syndrome are given. Histologic lesions were microcystic renal disease ("Finnish type"), diffuse glomerular mesangial sclerosis, glomerular mesangial proliferation and minimal changes in the 4 patients, respectively. Knowledge of the individual histologic lesion is essential for adequate therapy and the prognosis in all infants with nephrotic syndrome, except in cases with data proving the Finnish type; in some cases, the identification of individual histologic type will lead to adequate genetic counselling of the family.

Biopsy↗
PubMed1979

[Hypertensive emergencies in children with renal hypertension (author's transl)].

Hypertensive emergencies of 10 children with renal hypertension were analysed. Cause of renal disease are chronic renal failure in three, acute renal failure in three, hemolytic uremic syndrome in two, acute post streptococcal glomerulonephritis in one, and renal arterial stenosis in a further patient. Therapy should be started early in the course of the hypertensive emergency, first symptoms are headache and vomiting. Drug of first choice is diazoxide (3-5-(8)mg/kg i.v.). Three patients developed transitory hyperglycemia after repeated injections of diazoxide.

Acute Disease↗
PubMed1977

Cortisone cataract in children with nephrotic syndrome.

In a group of 16 children with idiopathic nephrotic syndrome treated with corticosteroids for longer than 12 months, 9 developed a posterior subcapsular cataract (PSC). No correlation between the frequency of PSC and the duration of treatment and the total dose of treatment with steroids was demonstrable. However, the patients with PSC had received considerably higher average daily doses than those without PSC. Two patients with normal ophthalmologic findings at the end of treatment showed PSC 6 and 9 months later respectively. Only one patient acquired a significant impairment of visus.

Adolescent↗
PubMed1977

[Current clinical problems in pediatric urology (author's transl)].

Recent epidemiologic studies document congenital urinary tract obstructions as most frequent cases of chronic renal insufficiency in children. Individual case analyses show avoidable delay and/or mistakes in diagnosis and/or treatment in surprising frequency. Current knowledge about vesicoureteral and intrarenal reflux, segmental hypoplasia and glomerular lesions in atrophic pyelonephritis are reviewed.

Age Factors↗
PubMed1976

The significance of focal sclerotic lesions of glomeruli in children.

To establish the relationship between the type of focal sclerotic lesion of glomeruli and the development of progressive renal disease, the clinical courses of 20 children with focal segmental and 7 with focal global sclerosis were analyzed. Only five patients, all of them with focal segmental sclerosis, did not have the nephrotic syndrome, although all had proteinuria. Results suggest that patients with focal global sclerosis have a course identical to that of children with the minimal lesion form of nephrotic syndrome: onset in early childhood, response to steroid therapy, and a relapsing, nonprogressive course. Focal segmental sclerosis, in constrast, is characterized by older age at onset, high incidence of nephritic symptoms, lack of response to steroid therapy, and a progressive course with histologic and functional deterioration. Since most published reports have not distinguished between these two entities, a more favorable prognosis in focal segmental sclerosis may be inferred than is actually the case.

Adolescent↗
PubMed1975

Neonatal changes in renal blood flow distribution in puppies.

The intrarenal distribution of blood flow was studied in 31 newborn mongrel puppies from 18 h to 70 days using xenon washout and krypton autoradiography. Mean renal blood flow increased from 0.39 plus or minus 0.05 ml/g per min (SE) the 1st wk to 2.06 plus or minus 0.12 ml/g per min at 6 wk. During the 1st wk of life renal cortex was perfused homo-geneously at 0.88 plus or minus 0.19 ml/g per min (SE) and accounted for 35 plus or minus 4% of the renal blood flow. During the 2nd wk a narrow, rapidly perfused zone of outer cortex was identified which was perfused at 3.35 plus or minus 0.26 ml/g per min, received 19.53 plus or minus 5.05% of the total renal blood flow, and represented 15 plus or minus 4% of the mass of the total cortex. The inner cortex and outer medulla at this time received 53.40 plus or minus 4.12% of the flow at 1.07 plus or minus 0.08 ml/g per min. Outer cortical flow increased with age reaching adult values by about 6-10 wk when the rapidly perfused area represented 40 plus or minus 8% of the cortex. These changes are parallel to the results of previously reported studies with microspheres in newborn puppies and are compatible with the well established maturational changes noted in neonates of several species. They represent the first gas-washout studies in animals during the first 6 wk of life.

Age Factors↗