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Biomedical subjects

H Oishi

Publications and source records attributed to H Oishi.

At least 91 records · Page 5Linked to original sources
PubMed1983

Tissue distribution and elimination of chlorinated naphthalenes in mice.

Male pathogen-free JCL:ICR mice were dosed i.p. 1 mg of 1,8-and 2,7-dichloronaphthalenes and octachloronaphthalene dissolved in olive oil. The highest levels of all chlorinated naphthalenes were found in adipose tissue. The biological half-life of octachloronaphthalene was longer than both dichloronaphthalenes while the half-life of 2,7-dichloronaphthalene was longer than that of 1,8-dichloronaphthalene in most tissues.

Animals↗
PubMed1982

Toxicity of several phosphoric acid esters in rats.

JCL--Wistar male rats were fed a diet containing 0 or 0.5% of trimethyl phosphate (TMP), triethyl phosphate (TEP), tri-n-butyl phosphate (TBP), trioctyl phosphate (TOP), or tricresyl phosphate (TCP) for 9 weeks. Body weights in TMP- and TBP-treated rats were significantly lower than the control. No differences in toxicity were observed among the test compounds, although there were differences between the treated and control rats in some organ weights, hematological values and serum components.

Animals↗
PubMed1982

Thiolactomycin, a new antibiotic. I. Taxonomy of the producing organism, fermentation and biological properties.

A strain of actinomycetes, isolated from a soil sample, has produced a novel antibiotic (C11H14O2S) containing a unique thiolactone moiety in its molecule. On the basis of taxonomic studies the producing organism was identified as belonging to the genus Nocardia. The antibiotic, named thiolactomycin, exhibits a broad antibacterial spectrum and particularly potent activity against Salmonella, Serratia and Bacteroides. Furthermore, the acute toxicity is weak in experimental animals. These results indicate that thiolactomycin is distinct from other known antibiotics and represents a new type of antibiotic.

Anti-Bacterial Agents↗
PubMed1982

Thiolactomycin, a new antibiotic. III. In vitro antibacterial activity.

Thiolactomycin is a new broad-spectrum antibiotic, active in vitro against many species of Gram-positive cocci, Enterobacteriaceae, Haemophilus, acid-fast bacteria and anaerobic bacteria. However, the activity is generally moderate and bacteriostatic in action. This antibiotic eludes cross resistance with any of the known antibacterial drugs such as ampicillin, carbenicillin or cycloserine. The effect on Gram-negative bacilli in vitro is little affected by the inoculum size, the presence of horse serum, the pH of the medium or the type of medium. When thiolactomycin was added to the assay medium, the minimum inhibitory concentration of ampicillin against inducible beta-lactamase producing strains of Staphylococcus aureus and Pseudomonas aeruginosa was reduced. Thiolactomycin inhibited the production of inducible beta-lactamase in several organisms.

Anti-Bacterial Agents↗
PubMed1980

Toxicity of tri-n-butyl phosphate, with special reference to organ weights, serum components and cholinesterase activity in male rats.

Toxicity of tri-n-butyl phosphate (TBP) was investigated in male rats with special reference to body and organ weights, serum components and cholinesterase (ChE) activity. Body weights of the treated groups were significantly lower than those of the control group. There was no difference in ChE activity in the serum, but that in the brain was significantly increased in vivo. The blood coagulation time of treated groups was significantly prolonged.

Animals↗
PubMed1978

Reexamination of paternal age effect in Down's syndrome.

Paternal age distribution for 1279 cases of Down's syndrome born in 1952--1968 was compared with the corresponding distribution for the general population, corrected for the maternal age as well as for the year of birth of the patients. Although there was no difference in the mean paternal age, the two distributions differed significantly, largely due to the excess of fathers aged 55 years and over and to the deficit of those aged 40--44 years in the patients born to mothers aged 30 years and over. The overall pattern of the relative incidence of Down's syndrome with advancing paternal age, with maternal age controlled, seems consistent with the hypothesis proposed by Stene et al. (1977). It increased from 0.8 for fathers aged 20--24 years slowly up to 1.2 for those aged 45--49 years, though with an intermediate drop to 0.8 at the age of 40--44 years, and then sharply to 2.4 for those aged 55 years and over. This rising pattern of the relative incidence with paternal age was essentially the same for the patients born in 1952--1960 and for those born in 1961--1968, although the slope was less steep in the latter than in the former group.

Adolescent↗
PubMed1978

Experimental studies and clinical report on the electrical alternans of ST segment during myocardial ischemia.

During myocardial ischemia produced in 43 dogs by occlusion of left coronary artery, electrical alternans developed in 34 experiments. The most common was alternans of ST-T complex. Surface and intracellular electrograms were recorded simultaneously from contiguous sites in the ischemic area. The alternans of ST-T complex in the surface electrogram corresponded to that of the rate of repolarization of the membrane action potential. The development of this alternans is localized in 2 relatively small area and transient. This may be the reason why electrical alternans of ST-T is clinically rare. A clinical case showing electrocardiographic changes of electrical alternans of ST-T complex without any change in the QRS complex is reported. Myocardial infarction and hypokalemia is considered as a cause of the alternans. The present results support the hypothesis that the mechanism of electrical alternans will be an alternation of the rate and extent of the ions transported across the myocardial cell membrane.

Aged↗