[Staging and prognosis in colorectal neoplasms].
Explore the source record for details and available documents.
Colonic Neoplasms↗
Biomedical subjects
H Ogihara
Publications and source records attributed to H Ogihara.
Mutant mice: a useful tool for studying the development of mast cells.
We have used various mouse mutants for studying the development of mast cells. The bone marrow origin of mast cells was shown by using giant granules of beige mice as a marker. Mast cell-deficient W/W(v) and Sl/Sl(d) mice are useful for investigation of the developmental processes. The mi locus encodes a member of the basic helix-loop-helix-leucine zipper protein family of transcription factors (MITF), and mast cells of mi/mi mice showed phenotypic abnormalities. Mast cells of mi/mi mice synthesized the mutant mi-MITF in normal amounts, and mi-MITF showed an inhibitory effect on the transcription of various mast cell-specific genes. On the other hand, mice of tg/tg possess the transgene insertional mutation in the 5' flanking region of the mi gene and do not express any MITFs. Genes whose transcription was suppressed were more numerous in mast cells of mi/mi mice than in those of tg/tg mice. The comparison between phenotypes of mi/mi mast cells and those of tg/tg mast cells gave some insights into the regulation of mast cell phenotypes by transcription factors.
Animals↗
The efficacy of immunochemotherapy with strontium (Sr) in the 1,2-dimethylhydrazine (DMH) induced rat carcinogenetic model: ultrastructural characteristics of the mitochondria in the liver.
It is said that stable strontium (Sr), which exists naturally in living cells as a microelement, has cytoprotective effects on liver cells in mammals. We attempted to examine the cytoprotective and anticancer effects of Sr using the rat carcinogenetic model induced by DMH (1,2-dimethylhydrazine). In a comparison of animals given UFT, PSK and Sr or UFT and PSK, carcinogenes in the colon and also increases in immunosuppressive acidic protein (IAP) levels were suppressed. Electron microscopic observation in the Sr group revealed a tendency toward stabilization of the mitochondrial membrane and highly developed rough endoplasmic reticulum in both the right and left lobe. This tendency became more obvious as the duration of oral intake of Sr was prolonged. Our study suggest that the cytoprotective effect of Sr on mitochondria in the liver may suppress carcinogenesis.
1,2-Dimethylhydrazine↗