Biomedical subjects
Publications and source records attributed to H Offret.
Ultrastructural study of two cases of persistent hyperplastic primary vitreous. Behind posterior lens capsule we find a connective tissue where fibroblasts present an intense activity. Numerous vessels and neuro-ectodermal tissue were noted.
Two cases of persistent hyperplastic primary vitreous have been managed by the vitreous cutter Sukon "Alternating" with a pars-plana approach.
Study of six cases of vitreous touch syndrom with histopathology of five buttoms of kératoplasty. Light and electron-microscopy demonstrate many alterations of Descemet's membrane, which is thickened, devided in sheets. In one specimen there was a retrocorneal fibrous membrane and "fibroblast like cells". These findings support the mechanism of endothelial fibrous metaplasia as the origin of the retrocorneal fibrous membrane during vitreous touch syndrom.
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A study was performed in two series of patients on whom lens extraction was done. Congenital cataracts were excluded from this study. In one series. the closure of the wounds was satisfactory; in the other, large anterior vitrectomy was carried out. The frequency of detachment (about 4%) seems to be approximately the same in the two series, but inflammatory signs and hypertony are more frequent when vitrectomy is not done.
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The histological appearance of an oncocytoma of the caruncle is reported, and the authors review the principle ocular sites for this rare and inusual tumour. They discuss the various hypotheses which have been advanced on the subject of their origin, particularly following ultrastructural findings which show chiefly a multiplication in the number of mitochondria which explains the granular appearance of the oncocytes on light microscopy.
A composite review of 24 cases of embryonal rhabdomyosarcoma which is seen in fact to be the commonest orbital malignant tumour in children. In its evolution, most often very rapid, sometimes pseudo-inflammatory, this tumour presents many different histological appearances among which the alveolar form and the botryoidal form should be particularly distinguished. Although it was for a long time confused with reticulosarcoma the tumour is in fact derived from primitive undifferentiated mesenchymal cells and can therefore in this sense be considered as a blastoma. Since the prognosis is grave and its treatment often disappointing, it should in many cases combine surgery with radiotherapy and polychemotherapy.
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